A multiplex qPCR approach for detection of pfhrp2 and pfhrp3 gene deletions in multiple strain infections of Plasmodium falciparum

scientific article published on 11 September 2019

A multiplex qPCR approach for detection of pfhrp2 and pfhrp3 gene deletions in multiple strain infections of Plasmodium falciparum is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41598-019-49389-2
P932PMC publication ID6739368
P698PubMed publication ID31511562

P50authorClaudia DaubenbergerQ88096920
Joana C SilvaQ88799111
Etienne A GuirouQ56388425
Tobias SchindlerQ56922690
Marcel TannerQ60043898
P2093author name stringProsper P Chaki
Stephen L Hoffman
Dionicia Gamboa
Salim Abdulla
Martina Fink
Kara A Moser
Katherine Torres
Said A Jongo
Michael G Mihayo
Anna C Deal
Jose R Bijeri
Paulo C Manrique Valverde
Solomon M Mwakasungula
P2860cites workpfhrp2 and pfhrp3 Gene Deletions That Affect Malaria Rapid Diagnostic Tests for Plasmodium falciparum: Analysis of Archived Blood Samples From 3 African CountriesQ93092385
Safety and Differential Antibody and T-Cell Responses to the Plasmodium falciparum Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and InfantsQ93148172
Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasitesQ24625172
Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reportingQ26825023
Secretion of a malarial histidine-rich protein (Pf HRP II) from Plasmodium falciparum-infected erythrocytesQ27972954
A novel clade of unique eukaryotic ribonucleotide reductase R2 subunits is exclusive to apicomplexan parasitesQ28661662
Transcription and expression of Plasmodium falciparum histidine-rich proteins in different stages and strains: implications for rapid diagnostic testsQ31028527
A review of malaria diagnostic tools: microscopy and rapid diagnostic test (RDT).Q33312812
A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests.Q33527400
Use of malaria RDTs in various health contexts across sub-Saharan Africa: a systematic reviewQ33706776
Multiplex qPCR for detection and absolute quantification of malariaQ34979479
Prevalence of pfhrp2 and pfhrp3 gene deletions in Puerto Lempira, HondurasQ35021355
Ultra-sensitive detection of Plasmodium falciparum by amplification of multi-copy subtelomeric targetsQ35142959
Genetic diversity of Plasmodium falciparum isolates from Pahang, Malaysia based on MSP-1 and MSP-2 genes.Q35690078
The reliability of diagnostic techniques in the diagnosis and management of malaria in the absence of a gold standard.Q36576513
False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmissionQ37713290
Prevalence and implications of multiple-strain infectionsQ37950538
Malaria rapid diagnostic tests: challenges and prospectsQ38139225
Pfhrp2-Deleted Plasmodium falciparum Parasites in the Democratic Republic of the Congo: A National Cross-sectional Survey.Q40340398
Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic testsQ41504973
Loop-mediated isothermal DNA amplification for asymptomatic malaria detection in challenging field settings: Technical performance and pilot implementation in the Peruvian Amazon.Q42370787
Molecular surveillance of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum isolates from MozambiqueQ42656095
Asymptomatic malaria infections: detectability, transmissibility and public health relevanceQ44146283
Plasmodium falciparum parasites with histidine-rich protein 2 (pfhrp2) and pfhrp3 gene deletions in two endemic regions of Kenya.Q44157364
Global analysis of Plasmodium falciparum histidine-rich protein-2 (pfhrp2) and pfhrp3 gene deletions using whole-genome sequencing data and meta-analysis.Q53685970
Epidemiological characterization of malaria in rural southern Tanzania following China-Tanzania pilot joint malaria control baseline surveyQ56343804
HRP-2 deletion: a hole in the ship of malaria eliminationQ56352516
Deletions of pfhrp2 and pfhrp3 genes of Plasmodium falciparum from Honduras, Guatemala and NicaraguaQ58782006
Molecular monitoring of the diversity of human pathogenic malaria species in blood donations on Bioko Island, Equatorial GuineaQ60908160
Genetic diversity and deletion of Plasmodium falciparum histidine-rich protein 2 and 3: a threat to diagnosis of P. falciparum malariaQ62488773
Ensuring quality and access for malaria diagnosis: how can it be achieved?Q79144554
P4510describes a project that usesggplot2Q326489
P433issue1
P921main subjectPlasmodium falciparumQ311383
P304page(s)13107
P577publication date2019-09-11
P1433published inScientific ReportsQ2261792
P1476titleA multiplex qPCR approach for detection of pfhrp2 and pfhrp3 gene deletions in multiple strain infections of Plasmodium falciparum
P478volume9