IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α-regulated pseudohypoxic state

scientific article published on 17 September 2019

IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α-regulated pseudohypoxic state is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.201901366R
P698PubMed publication ID31530011

P50authorE AgarwalQ55319427
Dario C AltieriQ98158352
P2093author name stringYuan Wang
Jagadish C Ghosh
Jae Ho Seo
Irene Bertolini
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cellsQ24302194
Direct regulation of TWIST by HIF-1alpha promotes metastasisQ24316939
Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxideQ24561904
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?Q26852282
Restoration of mitochondria function as a target for cancer therapyQ26864167
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionQ27025886
PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasionQ27324467
Comprehensive molecular characterization of clear cell renal cell carcinomaQ27852374
Mitochondrial tumour suppressors: a genetic and biochemical updateQ28285094
Why do cancers have high aerobic glycolysis?Q28290710
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumptionQ28300415
Modulation of oxidative stress as an anticancer strategyQ29615707
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicityQ29616651
Metabolic reprogramming: a cancer hallmark even warburg did not anticipateQ29617612
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instabilityQ29618122
Mitochondrial control by DRP1 in brain tumor initiating cellsQ30300490
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growthQ30300846
Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitorsQ30300847
Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cellsQ30576959
Chemotaxis in cancerQ30578627
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stressQ30581882
AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasionQ30806095
A neuronal network of mitochondrial dynamics regulates metastasisQ30833071
Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axonsQ33919516
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Q34217927
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanomaQ34299814
Up-regulated isocitrate dehydrogenase 1 suppresses proliferation, migration and invasion in osteosarcoma: in vitro and in vivoQ35187955
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasisQ35204528
Redox regulation of cell migration and adhesionQ35889032
Regulators of mitochondrial dynamics in cancerQ35929111
Oxidative stress inhibits distant metastasis by human melanoma cellsQ36277720
The hypoxic tumor microenvironment: A driving force for breast cancer progressionQ36368931
Notch signaling mediates hypoxia-induced tumor cell migration and invasionQ36609130
Mitochondrial localization and the persistent migration of epithelial cancer cellsQ36824448
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.Q37126990
The cancer diaspora: Metastasis beyond the seed and soil hypothesisQ37330159
Mitochondrial dynamics regulates migration and invasion of breast cancer cellsQ37548419
SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defenseQ37612791
The role of complex II in diseaseQ38061764
Tumorigenesis: it takes a villageQ38544200
Isocitrate dehydrogenase 2 inhibits gastric cancer cell invasion via matrix metalloproteinase 7.Q38820611
Metabolic Plasticity as a Determinant of Tumor Growth and MetastasisQ38944573
A mitochondrial switch promotes tumor metastasis.Q38971261
Suppression of tumorigenesis in mitochondrial NADP(+)-dependent isocitrate dehydrogenase knock-out miceQ39062488
Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem CellsQ39397584
Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular SignalingQ39436885
Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenaseQ42830565
IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear PolarityQ45048187
SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor GrowthQ46361797
Mitochondria and Cancer.Q53198693
Biological Role and Therapeutic Potential of IDH Mutations in Cancer.Q55456962
Targeting the Pathway in Acute Myeloid LeukemiaQ57462264
Mitochondria in cancer metabolism, an organelle whose time has come?Q88882190
Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell MovementsQ89093378
Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancerQ91051674
P433issue12
P304page(s)13398-13411
P577publication date2019-09-17
P1433published inFASEB JournalQ520194
P1476titleIDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α-regulated pseudohypoxic state
P478volume33

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