Neurofilaments in disease: what do we know?

scientific article published on 06 March 2020

Neurofilaments in disease: what do we know? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.CONB.2020.02.001
P932PMC publication ID7198337
P698PubMed publication ID32151970

P2093author name stringBrian A Gordon
P2860cites workSerum Neurofilament Light Is Elevated Differentially in Older Adults with Uncomplicated Mild Traumatic Brain InjuriesQ92185486
Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrumQ92252802
Plasma neurofilament light chain concentration is increased in anorexia nervosaQ92352901
CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementiaQ92355021
Confounding effect of blood volume and body mass index on blood neurofilament light chain levelsQ92361899
Serum Neurofilament Light Chain Concentration Correlates with Infarct Volume but Not Prognosis in Acute Ischemic StrokeQ92449558
Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measuresQ92641125
Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementiaQ92891960
Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD studyQ92985206
Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive ImpairmentQ93005980
Correlations between serum and CSF pNfH levels in ALS, FTD and controls: a comparison of three analytical approachesQ93103206
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALSQ24633692
The phosphorylated axonal form of the neurofilament subunit NF-H (pNF-H) as a blood biomarker of traumatic brain injuryQ24648646
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Increased CSF levels of phosphorylated neurofilament heavy protein following bout in amateur boxersQ28535187
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Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degenerationQ33610029
Elevated concentrations of neurofilament light chain in the cerebrospinal fluid of bipolar disorder patientsQ34068878
Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF.Q34402201
Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injuryQ34452753
A structural scaffolding of intermediate filaments in health and diseaseQ34453208
Neurofilament gene expression: a major determinant of axonal caliberQ34625359
Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementiaQ34746995
Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS.Q34792280
Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosisQ34975529
Axonal damage markers in cerebrospinal fluid are increased in ALS.Q53378093
Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic strokeQ57049032
Serum neurofilament light chain in behavioral variant frontotemporal dementiaQ57158113
Longitudinal Performance of Plasma Neurofilament Light and Tau in Professional Fighters: The Professional Fighters Brain Health StudyQ57464933
Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosisQ57476263
Cerebrospinal fluid neurofilament light in suspected sporadic Creutzfeldt-Jakob diseaseQ57481706
Neurofilaments as biomarkers in neurological disordersQ57588817
Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosisQ57623408
Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac ArrestQ58105080
Multicentre quality control evaluation of different biomarker candidates for amyotrophic lateral sclerosisQ58181716
Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer's diseaseQ58613374
Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disordersQ58763366
Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional studyQ59744545
Significance of CSF NfL and tau in ALSQ59901889
Neurofilament heavy-chain NfHSMI35 in cerebrospinal fluid supports the differential diagnosis of Parkinsonian syndromesQ60623883
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s diseaseQ60961744
Neurofilament light chain in blood is negatively associated with neuropsychological performance in HIV-infected adults and declines with initiation of antiretroviral therapyQ61698739
Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic strokeQ63535271
Blood neurofilament light chain as a biomarker of MS disease activity and treatment responseQ64064373
Prognostic value of serum neurofilaments in patients with clinically isolated syndromesQ64261900
Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's diseaseQ64264603
Neurofilament as a potential biomarker for spinal muscular atrophyQ64276902
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysisQ64761571
Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement DisordersQ64797205
Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson's diseaseQ64922770
Cerebrospinal fluid biomarkers of neurofibrillary tangles and synaptic dysfunction are associated with longitudinal decline in white matter connectivity: A multi-resolution graph analysis.Q64946685
Hereditary hypotrophic axonopathy with neurofilament deficiency in a mutant strain of the Japanese quailQ67846004
Reduced diameter and conduction velocity of myelinated fibers in the sciatic nerve of a neurofilament-deficient mutant quailQ70759792
Cytoskeleton proteins in CSF distinguish frontotemporal dementia from ADQ73816529
Neurofilament light protein and glial fibrillary acidic protein as biological markers in MSQ75205821
A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain proteinQ82713594
Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosisQ83465728
Serum neurofilament concentrations in children with prolonged febrile seizuresQ84729095
Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosisQ86613307
Neurofilament Light Chain Determination from Peripheral Blood SamplesQ86748852
Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosisQ88960884
Serum neurofilament light chain levels as a marker of upper motor neuron degeneration in patients with Amyotrophic Lateral SclerosisQ89122496
Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple SclerosisQ90084271
High serum neurofilament light chain normalizes after hematopoietic stem cell transplantation for MSQ90088600
Serum neurofilament heavy chains as early marker of motor neuron degenerationQ90093473
Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer DiseaseQ90139959
Neurofilament light: A candidate biomarker of presymptomatic amyotrophic lateral sclerosis and phenoconversionQ90266760
Neurofilament relates to white matter microstructure in older adultsQ90418013
Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer's diseaseQ90588474
Neurofilament changes in serum and cerebrospinal fluid after acute ischemic strokeQ90836973
A Pilot Cross-Sectional Study to Investigate the Biomarker Potential of Phosphorylated Neurofilament-H and Immune Mediators of Disability in Patients With 5 Year Relapsing-Remitting Multiple SclerosisQ90931002
Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort studyQ91183325
Postoperative delirium is associated with increased plasma neurofilament lightQ91698880
Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob DiseaseQ91784520
Increased neurofilament light chain blood levels in neurodegenerative neurological diseasesQ35000781
Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarkerQ35003970
Axonal degeneration and inflammation in acute optic neuritisQ35482336
Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosisQ35537489
Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.Q35686186
CSF neurofilament light chain reflects corticospinal tract degeneration in ALS.Q35935100
Neurofilament proteins in neurodegenerative diseasesQ35975762
Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and lossQ36129196
Monomer-polymer equilibria in the axon: direct measurement of tubulin and actin as polymer and monomer in axoplasmQ36209856
CSF neurofilament proteins in the differential diagnosis of dementiaQ36227579
Neurofilaments are obligate heteropolymers in vivoQ36233485
Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional StudyQ36538745
Plasma neurofilament light chain predicts progression in progressive supranuclear palsyQ36639639
CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndromeQ36840016
Serial soluble neurofilament heavy chain in plasma as a marker of brain injury after cardiac arrestQ36925772
Neurofilament light chain: a biomarker for genetic frontotemporal dementiaQ37208495
Neurofilament light chain level is a weak risk factor for the development of MS.Q37265143
Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementiaQ37304614
Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's diseaseQ37307467
Serum neurofilament light protein predicts clinical outcome in traumatic brain injuryQ37397309
Blood-based NfL: A biomarker for differential diagnosis of parkinsonian disorderQ37676938
CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration.Q38375870
Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasiasQ38381072
Serum neurofilament is associated with progression of brain atrophy and disability in early MS.Q38381437
Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosisQ38682945
Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosisQ38719337
Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and SimoaQ38882174
Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson DiseaseQ38975869
Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob diseaseQ39120758
Neurofilaments and Neurofilament Proteins in Health and DiseaseQ39217671
CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survivalQ39469698
Serum Neurofilament Light in American Football Athletes Over the Course of a SeasonQ40175729
CSF neurofilaments in frontotemporal dementia compared with early onset Alzheimer's disease and controlsQ40243703
Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis.Q40864697
Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patientsQ41462389
Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease ProgressionQ42287644
Elevated neurofilament levels in neurological diseases.Q42450342
Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab.Q44028578
CSF neurofilament light chain and tau differentiate multiple system atrophy from Parkinson's diseaseQ44422586
Neurofilament light chain as an early and sensitive predictor of long-term neurological outcome in patients after cardiac arrestQ44508621
Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcomeQ45284798
Phosphorylated neurofilament heavy subunit (pNF-H) in peripheral blood and CSF as a potential prognostic biomarker in amyotrophic lateral sclerosisQ45341922
pNfH is a promising biomarker for ALS.Q46303787
Neurofilament light and heavy subunits compared as therapeutic biomarkers in multiple sclerosisQ46910370
The neurofilament heavy chain (NfH) in the cerebrospinal fluid diagnosis of Alzheimer's diseaseQ46949879
Monitoring disease activity in multiple sclerosis using serum neurofilament light proteinQ47144073
Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegenerationQ47165587
Monoclonal antibodies selective for low molecular weight neurofilaments.Q47186756
Cerebrospinal fluid neurofilament light concentration in motor neuron disease and frontotemporal dementia predicts survivalQ47341318
Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral Sclerosis: Neurofilament Light Chain Levels in Definite Subtypes of DiseaseQ47424783
Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosisQ47572013
Serum neurofilament light is sensitive to active cerebral small vessel diseaseQ47631966
Neurofilament light protein in blood predicts regional atrophy in Huntington diseaseQ47841281
CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP.Q47893422
Comparison of elevated phosphorylated neurofilament heavy chains in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosisQ48008806
CSF neurofilament proteins levels are elevated in sporadic Creutzfeldt-Jakob diseaseQ48162267
The CSF neurofilament light signature in rapidly progressive neurodegenerative dementiasQ48168855
A specific ELISA for measuring neurofilament heavy chain phosphoformsQ48207023
Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer DiseaseQ48243501
CSF neurofilament proteins as diagnostic and prognostic biomarkers for amyotrophic lateral sclerosisQ48265513
Serum neurofilament light chain in patients with acute cerebrovascular eventsQ48343364
The Serum Phosphorylated Neurofilament Heavy Subunit as a Predictive Marker for Outcome in Adult Patients after Traumatic Brain InjuryQ48473595
Serum Neurofilament Light Protein as a Marker for Diffuse Axonal Injury: Results from a Case Series StudyQ48562884
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative DiseasesQ48682038
CSF neurofilament protein analysis in the differential diagnosis of ALS.Q48699278
Hyperacute detection of neurofilament heavy chain in serum following stroke: a transient signQ48986769
Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity.Q49015259
Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseasesQ49392411
Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ1-42, total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40.Q50065238
Plasma neurofilament light chain concentration in the inherited peripheral neuropathiesQ50102118
Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer's disease in late-middle-aged adults.Q50591921
Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports.Q50731678
Serial CSF sampling in Alzheimer's disease: specific versus non-specific markers.Q50794881
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Q50940972
Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease.Q51004875
Neurofilament light chain in cerebrospinal fluid and prediction of disease activity in clinically isolated syndrome and relapsing-remitting multiple sclerosis.Q51110507
Neurofilament light and tau as blood biomarkers for sports-related concussion.Q52543726
Association of Plasma Neurofilament Light Chain with Neocortical Amyloid-β Load and Cognitive Performance in Cognitively Normal Elderly Participants.Q52598833
Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod.Q53212006
Neurofilament protein levels in CSF are increased in dementia.Q53227032
P304page(s)105-115
P577publication date2020-03-06
P1433published inCurrent Opinion in NeurobiologyQ15763572
P1476titleNeurofilaments in disease: what do we know?
P478volume61

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