Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor

scientific article published on 19 September 2019

Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0222779
P932PMC publication ID6752849
P698PubMed publication ID31536596

P50authorCollynn F WoellerQ90179006
P2093author name stringRichard P Phipps
Steven E Feldon
Christine L Hammond
Elisa Roztocil
P2860cites work2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway: role of the transcription activaton and DNA binding of AhRQ23919662
Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ ConvergeQ26782820
Recent developments in myofibroblast biology: paradigms for connective tissue remodelingQ26863751
25 Years of Proton Pump Inhibitors: A Comprehensive ReviewQ28070003
Nrf2-inducing anti-oxidation stress response in the rat liver--new beneficial effect of lansoprazoleQ28538990
Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosisQ28660307
Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).Q30422043
What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and diseaseQ30429628
Differential effects of omeprazole and lansoprazole enantiomers on aryl hydrocarbon receptor in human hepatocytes and cell linesQ33700433
A critical evaluation of proton pump inhibitors in the treatment of gastroesophageal reflux disease.Q34025656
The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasisQ34485137
New advances in understanding thyroid-associated ophthalmopathy and the potential role for insulin-like growth factor-I receptor.Q55024151
A new highly thyrotropin receptor-selective small molecule antagonist with potential for the treatment of Graves' orbitopathyQ57800155
Proton pump inhibitors: Review of reported risks and controversiesQ60128927
Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitroQ79843215
Interaction between the aryl hydrocarbon receptor and transforming growth factor-beta signaling pathways: evidence of an asymmetrical relationship in rat granulosa cellsQ81955419
Teprotumumab for Thyroid-Associated Ophthalmopathy.Q34556184
Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implicationsQ34561866
The aryl hydrocarbon receptor ligand ITE inhibits TGFβ1-induced human myofibroblast differentiationQ34805707
Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformationQ35125945
Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymesQ35265520
Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosisQ35908085
Ah receptor signals cross-talk with multiple developmental pathwaysQ35997552
Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cellsQ36335539
The pathophysiology of thyroid eye disease: implications for immunotherapy.Q36439938
Fitting a xenobiotic receptor into cell homeostasis: how the dioxin receptor interacts with TGFbeta signalingQ37277392
Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathwaysQ37291837
Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptorQ37514105
Graves' orbitopathy: imperfect treatments for a rare diseaseQ37582446
Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model.Q37607150
Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.Q38355897
MyofibroblastsQ38550797
Current Insights into the Pathogenesis of Graves' OphthalmopathyQ38585018
Current perspectives on the role of orbital fibroblasts in the pathogenesis of Graves' ophthalmopathyQ38671312
Proton pump inhibitor pantoprazole inhibits the proliferation, self‑renewal and chemoresistance of gastric cancer stem cells via the EMT/β‑catenin pathwaysQ38740654
The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation: Implications for Thyroid Eye DiseaseQ38795531
The Role of Biological Agents and Immunomodulators in Treatment Strategies for Thyroid Eye Disease: An Evidence-based ReviewQ38849908
Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathwaysQ39008804
Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitorsQ40205035
Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1).Q42501461
Effects of omeprazole on neutrophil chemotaxis, super oxide production, degranulation, and translocation of cytochrome b-245Q43221245
The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic valueQ47281033
Esomeprazole ameliorates CCl4 induced liver fibrosis in rats via modulating oxidative stress, inflammatory, fibrogenic and apoptotic markersQ47383813
Lansoprazole prevents the progression of liver fibrosis in non-alcoholic steatohepatitis model rats.Q47803690
Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self-tolerance for a murine model of autoimmune thyroid disease and Graves' orbitopathyQ48147801
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue9
P921main subjecteye diseaseQ3041498
P304page(s)e0222779
P577publication date2019-09-19
P1433published inPLOS OneQ564954
P1476titleProton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
P478volume14

Reverse relations

cites work (P2860)
Q98465424Proton Pump Inhibitors and Osteoporosis: Is Collagen a Direct Target?
Q95322318The aryl hydrocarbon receptor pathway controls matrix metalloproteinase-1 and collagen levels in human orbital fibroblasts

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