Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition

scientific article published on 30 August 2019

Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FMICB.2019.01965
P932PMC publication ID6730261
P698PubMed publication ID31543869

P2093author name stringFernando Ruiz-Perez
Fernando Navarro-Garcia
Ángel Cataldi
Mariano Larzábal
P2860cites workVibrio cholerae type 6 secretion system effector trafficking in target bacterial cellsQ46321188
The genome sequence of E. coli W (ATCC 9637): comparative genome analysis and an improved genome-scale reconstruction of E. coliQ21266710
Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model systemQ24537443
What is type VI secretion doing in all those bugs?Q24594338
The type VI secretion toolkitQ24644999
PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systemsQ46456498
In vivo structures of an intact type VI secretion system revealed by electron cryotomographyQ46764741
The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene TransferQ47251475
Structure-Function Analysis of the C-Terminal Domain of the Type VI Secretion TssB Tail Sheath SubunitQ47311961
Identification of a novel gene in ROD9 island of Salmonella Enteritidis involved in the alteration of virulence-associated genes expressionQ47410801
Dissection of a type VI secretion system in Edwardsiella tardaQ48076617
Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complexQ48222755
T6SS intraspecific competition orchestrates Vibrio cholerae genotypic diversityQ49985263
Imaging type VI secretion-mediated bacterial killing.Q50485497
Adaptor Proteins of Type VI Secretion System Effectors.Q51322442
Molecular Dissection of the Interface between the Type VI Secretion TssM Cytoplasmic Domain and the TssG Baseplate Component.Q51531303
Structure-Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes.Q51531311
Diverse toxic effectors are harbored by vgrG islands for interbacterial antagonism in type VI secretion system.Q52576837
The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer.Q53348717
A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery.Q54253962
Heterogeneity of enteroaggregative Escherichia coli virulence demonstrated in volunteers.Q54617716
Three Hcp homologs with divergent extended loop regions exhibit different functions in avian pathogenic Escherichia coli.Q55094311
In vivo TssA proximity labelling during type VI secretion biogenesis reveals TagA as a protein that stops and holds the sheathQ57060056
Biogenesis and structure of a type VI secretion baseplateQ57464807
Structure of the type VI secretion system TssK-TssF-TssG baseplate subcomplex revealed by cryo-electron microscopyQ60300791
Characterization of multiple type-VI secretion system (T6SS) VgrG proteins in the pathogenicity and antibacterial activity of porcine extra-intestinal pathogenic Escherichia coliQ61810844
Bidirectional contraction of a type six secretion systemQ64073432
and high-resolution cryo-EM structure of a bacterial type VI secretion system membrane complexQ64086440
Comparative Genome Analysis of an Extensively Drug-Resistant Isolate of Avian Sequence Type 167 Strain Sanji with Novel Serotype O89b:H9Q64102322
The different roles of hcp and hcp of the type VI secretion system in Escherichia coli strain CE129Q64448447
Comparative Transcriptome Profiling Reveals a Potential Role of Type VI Secretion System and Fimbriae in Virulence of Non-O157 Shiga Toxin-ProducingQ64448554
Identification of a unique IAHP (IcmF associated homologous proteins) cluster in Vibrio cholerae and other proteobacteria through in silico analysisQ73897572
Effector⁻Immunity Pairs Provide the T6SS Nanomachine its Offensive and Defensive CapabilitiesQ88492164
The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube AssemblyQ90385366
ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretionQ95480308
Type VI secretion system: secretion by a contractile nanomachineQ26787001
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary originQ27653977
Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity PairQ27679179
PAAR-repeat proteins sharpen and diversify the type VI secretion system spikeQ27679451
Structure and properties of the C-terminal β-helical domain of VgrG protein from Escherichia coli O157Q27687827
Biogenesis and structure of a type VI secretion membrane core complexQ27701595
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophagesQ28238270
Type VI secretion is a major virulence determinant in Burkholderia malleiQ28305456
Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actinQ28485710
Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosaQ28492573
Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesisQ28492577
A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic miceQ28492582
Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteinsQ28492592
A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteriaQ28492922
Genetically distinct pathways guide effector export through the type VI secretion systemQ28493007
VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion SystemQ28552230
The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition.Q30360835
Shiga toxin 2a and Enteroaggregative Escherichia coli--a deadly combinationQ30360953
Type VI secretion requires a dynamic contractile phage tail-like structureQ30530331
Secretome analysis of Vibrio cholerae type VI secretion system reveals a new effector-immunity pairQ30908434
Intraspecies Competition in Serratia marcescens Is Mediated by Type VI-Secreted Rhs Effectors and a Conserved Effector-Associated Accessory ProteinQ30943932
Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacementQ30962327
The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systemsQ31153284
The Francisella pathogenicity island protein IglA localizes to the bacterial cytoplasm and is needed for intracellular growthQ33269612
Identification and functional characterization of gene components of Type VI Secretion system in bacterial genomesQ33359587
Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?Q33417905
Large genomic sequence repetitions in bacteria: lessons from rRNA operons and Rhs elementsQ33836575
Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coliQ33927393
Nooks and crannies in type VI secretion regulation.Q34045539
Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar TyphimuriumQ34074392
Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomicsQ34283923
Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathwaysQ34298499
Lytic activity of the Vibrio cholerae type VI secretion toxin VgrG-3 is inhibited by the antitoxin TsaB.Q34323842
Use of proteomics to identify novel virulence determinants that are required for Edwardsiella tarda pathogenesisQ34330362
Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substratesQ34364793
Type VI secretion system effectors: poisons with a purposeQ34395319
Type VI secretion and bacteriophage tail tubes share a common assembly pathwayQ34401628
DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coliQ34471456
Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio choleraeQ34567332
Type VI secretion: a beginner's guideQ34752940
Systematic dissection of the agrobacterium type VI secretion system reveals machinery and secreted components for subcomplex formationQ34825763
Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretionQ34918172
Dissection of the TssB-TssC interface during type VI secretion sheath complex formationQ35055208
Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cellsQ35125979
Generation of reactive oxygen species by lethal attacks from competing microbesQ35128847
Genome based phylogeny and comparative genomic analysis of intra-mammary pathogenic Escherichia coliQ35216942
The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath PolymerizationQ35804578
Hcp family proteins secreted via the type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cellsQ35805527
Structural biology of type VI secretion systemsQ35814718
A widespread bacterial type VI secretion effector superfamily identified using a heuristic approachQ35982125
Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS)Q36306336
An ABC transporter and an outer membrane lipoprotein participate in posttranslational activation of type VI secretion in Pseudomonas aeruginosa.Q36306345
Pathogenesis of enteroaggregative Escherichia coli infectionQ36383861
Secretome analysis uncovers an Hcp-family protein secreted via a type VI secretion system in Agrobacterium tumefaciensQ36540557
Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophilaQ36724845
Diverse type VI secretion phospholipases are functionally plastic antibacterial effectorsQ36839898
Roles of Hcp family proteins in the pathogenesis of the porcine extraintestinal pathogenic Escherichia coli type VI secretion systemQ36941397
Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic islandQ36994573
A conserved alpha-helix essential for a type VI secretion-like system of Francisella tularensisQ37157058
TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the type VI secretion systemQ37189426
Genomic islands of uropathogenic Escherichia coli contribute to virulenceQ37191735
Common themes and variations in serine protease autotransportersQ37205333
Proteomic identification of novel secreted antibacterial toxins of the Serratia marcescens type VI secretion system.Q37214662
Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli.Q37307118
The type VI secretion system: translocation of effectors and effector-domainsQ37375434
Contractile tail machines of bacteriophagesQ37980623
Enteroaggregative Escherichia coli pathotype: a genetically heterogeneous emerging foodborne enteropathogenQ38024836
Architecture and assembly of the Type VI secretion system.Q38200408
VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectorsQ38231827
Secretion systems in Gram-negative bacteria: structural and mechanistic insights.Q38482854
TssA: The cap protein of the Type VI secretion system tail.Q38620180
Type VI secretion and anti-host effectorsQ38684791
The Type VI Secretion System in Escherichia coli and Related Species.Q38844038
Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteriaQ39424297
Characterization of IcmF of the type VI secretion system in an avian pathogenic Escherichia coli (APEC) strain.Q39502999
The Legionella pneumophila icmGCDJBF genes are required for killing of human macrophagesQ39571241
BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLBQ39664786
A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepaciaQ40006381
FNR Regulates the Expression of Important Virulence Factors Contributing to the Pathogenicity of Avian Pathogenic Escherichia coliQ40142217
The HsiB1C1 (TssB-TssC) complex of the Pseudomonas aeruginosa type VI secretion system forms a bacteriophage tail sheathlike structureQ41116566
Horizontal Gene Transfer of Functional Type VI Killing Genes by Natural Transformation.Q41126951
Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule NetworkQ41189092
Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG subcomplexQ41253912
The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cellsQ41469984
Genomic comparison of Escherichia coli K1 strains isolated from the cerebrospinal fluid of patients with meningitisQ41957733
Quorum sensing and silencing in Vibrio parahaemolyticusQ42150850
Sequential displacement of Type VI Secretion System effector genes leads to evolution of diverse immunity gene arrays in Vibrio choleraeQ42314845
The Type VI Secretion System Plays a Role in Type 1 Fimbria Expression and Pathogenesis of an Avian Pathogenic Escherichia coli StrainQ42363502
Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coliQ42596037
The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coliQ42938903
Genetic diversity and features analysis of type VI secretion systems loci in avian pathogenic Escherichia coli by wide genomic scanningQ44599095
Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistanceQ46179212
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectEscherichia coliQ25419
P304page(s)1965
P577publication date2019-08-30
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleType VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition
P478volume10

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cites work (P2860)
Q90567279Advanced Proteomics as a Powerful Tool for Studying Toxins of Human Bacterial Pathogens
Q92637327Clinical, Ultrasonographic, Bacteriological, Cytological and Histopathological Findings of Uterine Involution in Ewes with Uterine Infection
Q94502727HpaR, the Repressor of Aromatic Compound Metabolism, Positively Regulates the Expression of T6SS4 to Resist Oxidative Stress in Yersinia pseudotuberculosis

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