Effects of Fish Oil Monotherapy on Depression and Prefrontal Neurochemistry in Adolescents at High Risk for Bipolar I Disorder: A 12-Week Placebo-Controlled Proton Magnetic Resonance Spectroscopy Trial

scientific article published on 11 March 2020

Effects of Fish Oil Monotherapy on Depression and Prefrontal Neurochemistry in Adolescents at High Risk for Bipolar I Disorder: A 12-Week Placebo-Controlled Proton Magnetic Resonance Spectroscopy Trial is …
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scholarly articleQ13442814

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P356DOI10.1089/CAP.2019.0124
P932PMC publication ID7310320
P698PubMed publication ID32167792

P50authorMelissa P DelBelloQ91939875
P2093author name stringJeffrey A Welge
Robert K McNamara
Jeffrey R Strawn
Thomas J Blom
L Rodrigo Patino
Max J Tallman
P2860cites workEstimation of metabolite concentrations from localized in vivo proton NMR spectraQ72319396
Evaluation of cerebral gray and white matter metabolite differences by spectroscopic imaging at 4.1TQ72376930
Prodromal symptoms before onset of manic-depressive disorder suggested by first hospital admission historiesQ73063968
Standardization of the PFA-100(R) platelet function test in 105 mmol/l buffered citrate: effect of gender, smoking, and oral contraceptivesQ73079802
Rapid incorporation of docosahexaenoic acid from dietary sources into brain microsomal, synaptosomal and mitochondrial membranes in adult miceQ73669639
A Double-Blind Placebo-Controlled Trial of Omega-3 Fatty Acids as a Monotherapy for Adolescent DepressionQ89473280
Efficacy and Tolerability of Pharmacotherapy for Pediatric Anxiety Disorders: A Network Meta-AnalysisQ91502993
Meta-Analysis of the Effects of Eicosapentaenoic Acid (EPA) in Clinical Trials in DepressionQ22305455
Omega-3 fatty acids for depression in adultsQ24187951
A children's global assessment scale (CGAS)Q28271291
A rating scale for mania: reliability, validity and sensitivityQ29619299
In vivo 1H NMR spectroscopy of rat brain at 1 ms echo timeQ30577367
Baseline blood levels of omega-3 and depression remission: a secondary analysis of data from a placebo-controlled trial of omega-3 supplementsQ31050854
Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trialsQ33578486
Psychotropic medication exposure and age at onset of bipolar disorder in offspring of parents with bipolar disorderQ33714517
Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections.Q33943502
Cross-national comparisons of seafood consumption and rates of bipolar disordersQ33974158
Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depressionQ34014195
Type and duration of subsyndromal symptoms in youth with bipolar I disorder prior to their first manic episodeQ34294725
Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysisQ34352492
Automatic, localized in vivo adjustment of all first- and second-order shim coilsQ34352735
Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept studyQ34468355
Review of studies of child and adolescent offspring of bipolar parentsQ34530094
Cognitive behavioral therapy, sertraline, or a combination in childhood anxietyQ34869621
Diagnostic Precursors to Bipolar Disorder in Offspring of Parents With Bipolar Disorder: A Longitudinal StudyQ35811945
Glutamatergic effects of divalproex in adolescents with mania: a proton magnetic resonance spectroscopy study.Q35843375
Treatment-emergent mania in pediatric bipolar disorder: a retrospective case reviewQ35909656
Relation between red blood cell omega-3 fatty acid index and bleeding during acute myocardial infarctionQ36081403
A systematic review and meta-analysis of prospective transition from major depression to bipolar disorderQ36252218
Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy studyQ36295874
First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapineQ36305068
A Randomized Controlled Trial of Individual Family Psychoeducational Psychotherapy and Omega-3 Fatty Acids in Youth with Subsyndromal Bipolar Disorder.Q36405769
Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker.Q36759325
Expert opinion: omega-3 fatty acids and bleeding-cause for concern?Q36763078
Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder.Q36915538
Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorderQ36940652
A comprehensive review and model of putative prodromal features of bipolar affective disorder.Q36941947
Docosahexaenoic acid promotes hippocampal neuronal development and synaptic functionQ37412199
Symptoms and signs of the initial prodrome of bipolar disorder: a systematic reviewQ37626234
Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study.Q37712537
Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder.Q37720606
A meta-analytic review of polyunsaturated fatty acid compositions in patients with depressionQ37746266
A depression rating scale for childrenQ38556347
Dietary n-3 PUFA, fish consumption and depression: A systematic review and meta-analysis of observational studiesQ38932759
Dietary patterns and depression risk: A meta-analysisQ39255050
A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarityQ40016044
The predictive validity of bipolar at-risk (prodromal) criteria in help-seeking adolescents and young adults: a prospective studyQ40189055
Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acidQ40445306
Emulsified omega-3 fatty-acids modulate the symptoms of depressive disorder in children and adolescents: a pilot study.Q40963212
Choline in pediatric depression.Q42134296
Inhibition of astroglial glutamate transport by polyunsaturated fatty acids: evidence for a signalling role of docosahexaenoic acidQ42453489
n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: effect of rest and neuronal activation in the rat.Q42506215
Role of monoaminergic system in the etiology of olive oil induced antidepressant and anxiolytic effects in ratsQ43070876
Omega-3 fatty acids deprivation affects ontogeny of glutamatergic synapses in rats: relevance for behavior alterationsQ43155661
A randomized, placebo-controlled study of duloxetine for the treatment of children and adolescents with generalized anxiety disorder.Q43699931
Associations between central and peripheral measures of phospholipid breakdown revealed by cerebral 31-phosphorus magnetic resonance spectroscopy and fatty acid composition of erythrocyte membranes.Q43772382
Proton magnetic resonance spectroscopic imaging in pediatric major depressionQ44061643
International variations in the outcome of schizophrenia and the prevalence of depression in relation to national dietary practices: an ecological analysisQ44880962
Increased parental history of bipolar disorder in the United States: association with early age of onsetQ44962068
Age effects on antidepressant-induced manic conversionQ45003904
Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation.Q46155653
A pilot study of antidepressant-induced mania in pediatric bipolar disorder: Characteristics, risk factors, and the serotonin transporter geneQ46301946
Correlation between choline signal intensity and acetylcholine level in different brain regions of rat.Q46947003
Multigenerational Positive Family History of Psychiatric Disorders Is Associated With a Poor Prognosis in Bipolar DisorderQ46948351
Antidepressant exposure in bipolar childrenQ47204446
Omega-3 supplementation associated with improved parent-rated executive function in youth with mood disorders: secondary analyses of the omega 3 and therapy (OATS) trials.Q47235837
Individual and familial risk factors for bipolar affective disorders in DenmarkQ47334174
Fish consumption and major depressionQ47757469
Antidepressant tolerability in anxious and depressed youth at high risk for bipolar disorder: a prospective naturalistic treatment study.Q47990576
Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo1H MRS studyQ48011520
Pilot Randomized Controlled Trial of Omega-3 and Individual-Family Psychoeducational Psychotherapy for Children and Adolescents With Depression.Q48036852
Psychoeducational Psychotherapy and Omega-3 Supplementation Improve Co-Occurring Behavioral Problems in Youth with Depression: Results from a Pilot RCT.Q48041573
A Longitudinal (6-week) 3T (1)H-MRS Study on the Effects of Lithium Treatment on Anterior Cingulate Cortex Metabolites in Bipolar DepressionQ48073482
Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients.Q50495766
Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial.Q50707428
A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression.Q50924850
Safety and tolerability of prescription omega-3 fatty acids: A systematic review and meta-analysis of randomized controlled trials.Q51246512
Adolescents' self-assessment of sexual maturation.Q52296263
Omega-3 treatment of childhood depression: a controlled, double-blind pilot study.Q55042041
Multigenerational transmission of liability to psychiatric illness in offspring of parents with bipolar disorderQ56535598
Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studiesQ57471889
High contrast and fast three-dimensional magnetic resonance imaging at high fieldsQ63894361
Bipolar illness in adolescents with major depression: clinical, genetic, and psychopharmacologic predictors in a three- to four-year prospective follow-up investigationQ70392247
Use of the Children's Depression Rating Scale in an inpatient psychiatric populationQ71741014
P921main subjectplaceboQ269829
neurochemistryQ786278
fish oilQ1786125
bipolar I disorderQ4915474
P577publication date2020-03-11
P1433published inJournal of Child and Adolescent PsychopharmacologyQ15756086
P1476titleEffects of Fish Oil Monotherapy on Depression and Prefrontal Neurochemistry in Adolescents at High Risk for Bipolar I Disorder: A 12-Week Placebo-Controlled Proton Magnetic Resonance Spectroscopy Trial