Discovery of Affinity-Based Probes for Btk Occupancy Assays

scientific article published on 09 January 2019

Discovery of Affinity-Based Probes for Btk Occupancy Assays is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CMDC.201800714
P698PubMed publication ID30521698

P50authorHui QiuQ90307971
P2093author name stringFederica Morandi
Ariele Viacava Follis
Daigen Xu
Igor Mochalkin
Brian Sherer
Roland Grenningloh
Jared Head
Lesley Liu-Bujalski
Richard Caldwell
Theresa Johnson
Andrew Bender
Anna Gardberg
Andreas Goutopoulos
Reinaldo Jones
Justin Potnick
P2860cites workThe Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancyQ24633214
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Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignanciesQ33893704
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemiaQ34052075
Regulation of B lymphocyte development and activation by Bruton's tyrosine kinaseQ34303128
A novel 2,5-diaminopyrimidine-based affinity probe for Bruton's tyrosine kinaseQ36288294
Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disordersQ38011765
B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.Q38124120
Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitorQ38938436
A general approach for the development of fluorogenic probes suitable for no-wash imaging of kinases in live cellsQ38944958
Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humansQ39412429
Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritisQ42791258
Btk function in B cell development and response.Q45939727
Btk inhibition treats TLR7/IFN driven murine lupus.Q50886199
Development of a Selective Labeling Probe for Bruton's Tyrosine Kinase Quantification in Live Cells.Q54116270
Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of BtkQ57067987
Recent developments of small molecule chemical probes for fluorescence-based detection of human carbonic anhydrase II and IXQ61910924
Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hitQ91024080
Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitorsQ91651285
P433issue2
P304page(s)217-223
P577publication date2019-01-09
P1433published inChemMedChemQ2962252
P1476titleDiscovery of Affinity-Based Probes for Btk Occupancy Assays
P478volume14

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