MDR1 in immunity: friend or foe?

scientific article published on 06 September 2018

MDR1 in immunity: friend or foe? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/2162402X.2018.1499388
P932PMC publication ID6279327
P698PubMed publication ID30524890

P50authorChristophe CauxQ56528905
Christine Ménétrier-CauxQ71006396
P2093author name stringAnthony Di Roio
Marion Bossennec
P2860cites workP-glycoprotein functions as a differentiation switch in antigen presenting cell maturationQ79327750
The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipientsQ79781706
Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritisQ80693015
Expression of the MDR1 and MRP genes in patients with lymphoma with primary bone marrow involvementQ81048531
Expression of multidrug resistance-1 protein correlates with disease activity rather than the refractoriness to methotrexate therapy in rheumatoid arthritisQ83174787
Autocrine Adenosine Regulates Tumor Polyfunctional CD73+CD4+ Effector T Cells Devoid of Immune CheckpointsQ88112395
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseasesQ24601963
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug bindingQ24657908
Targeting the Y/CCAAT box in cancer: YB-1 (YBX1) or NF-Y?Q27006654
Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cellsQ28275578
Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factorQ28344451
Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis miceQ28608251
Role of P-glycoprotein in human natural killer-like cell line-mediated cytotoxicityQ30822542
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)Q33194199
Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cellsQ33205916
Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML).Q33319637
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificitiesQ33495468
Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibodyQ33611565
Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)Q33758413
The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membraneQ34074379
ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cellsQ34463998
MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patientsQ34640725
Mammalian ABC transporters in health and diseaseQ34667449
Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)Q34994901
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.Q35048738
Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemiaQ35377371
Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics.Q35538527
Development of Fourth Generation ABC Inhibitors from Natural Products: A Novel Approach to Overcome Cancer Multidrug ResistanceQ35542125
Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapyQ35915497
Alterations in P-Glycoprotein Expression and Function Between Macrophage SubsetsQ36081148
Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.Q36386127
Circulating and tumor-infiltrating mucosal associated invariant T (MAIT) cells in colorectal cancer patientsQ36536034
Immune cell dysfunctions in breast cancer patients detected through whole blood multi-parametric flow cytometry assay.Q36821232
Characterization of the human MDR1 geneQ37361988
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.Q37483138
Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment.Q37709960
P-glycoprotein Inhibition for Optimal Drug Delivery.Q38136183
Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosisQ50449094
Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus.Q50930116
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.Q51030308
Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients. The percentage of lymphocytes expressing glycoprotein 170 is increased in patients treated with prednisolone.Q51031015
Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma.Q53800155
Differential expression of the efflux pumps P-glycoprotein and multidrug resistance-associated protein in human monocyte-derived dendritic cells.Q53991268
No evidence of significant activity of the multidrug resistance gene product in primary human breast cancer.Q54136949
Mdr1 gene expression in childhood acute lymphoblastic leukemias and lymphomas: a critical evaluation by four techniques.Q54216273
Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding siteQ54242483
P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell deathQ57272499
Prediction of response to disease modifying antirheumatic drugs in rheumatoid arthritisQ59399994
Interferon-gamma up-regulates expression and activity of P-glycoprotein in human peripheral blood monocyte-derived macrophagesQ59491332
Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemiaQ72229025
Altered development of intestinal intraepithelial lymphocytes in P-glycoprotein-deficient miceQ74037893
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.Q38288114
P-glycoprotein (encoded by multidrug resistance genes) is not required for interleukin-2 secretion in mice and humansQ38303929
Fragmented hyaluronan induces transcriptional up-regulation of the multidrug resistance-1 gene in CD4+ T cellsQ38308601
Transcriptional regulation of multidrug resistance-1 gene by interleukin-2 in lymphocytesQ38333745
CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.Q38980123
Expression of multidrug resistance 1 gene in B-cell lymphomas: association with follicular dendritic cellsQ39206827
A subset of virus-specific CD161+ T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML.Q39207628
MicroRNA-145 post-transcriptionally regulates the expression and function of P-glycoprotein in intestinal epithelial cells.Q39242104
Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphomaQ39596590
Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastomaQ39787158
Substrate-dependent effects of human ABCB1 coding polymorphismsQ40011132
Rituximab but not other anti-CD20 antibodies reverses multidrug resistance in 2 B lymphoma cell lines, blocks the activity of P-glycoprotein (P-gp), and induces P-gp to translocate out of lipid raftsQ40232195
Verapamil induces upregulation of P-glycoprotein expression on human monocyte derived dendritic cellsQ40306083
An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-gp) and CD19, causes P-gp to translocate out of lipid rafts, and chemosensitizes a multidrug-resistant (MDR) lymphoma cell lineQ40582263
Mitotracker green is a P-glycoprotein substrateQ40592480
Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistanceQ40595494
The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influenceQ40767154
Role of multidrug resistance P-glycoprotein in the secretion of aldosterone by human adrenal NCI-H295 cellsQ40876122
Reduction of intracellular pH by inhibitors of natural killer cell activity, nicardipine, methyl 2-(N-benzyl-N-methylamino)ethyl-2,6-dimethyl-4-(2-isopropyl-pyrazolo[1, 5-a]pyridine-3-yl)-1,4-dihydro-pyridine-3,5-dicarboxylate (AHC-52), and 4,4'-diiQ41100685
Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes.Q41172472
P-170 glycoprotein (P-170) is involved in the impairment of natural killer cell-mediated cytotoxicity in HIV+ patientsQ41298524
Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesteroneQ41590183
Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotypeQ41592100
Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoproteinQ41874604
Preferential expression and activity of multidrug resistance gene 1 product (P-glycoprotein), a functionally active efflux pump, in human CD8+ T cells: a role in cytotoxic effector functionQ41939298
CD161-expressing human T cells.Q42082102
Altered generation of induced regulatory T cells in the FVB.mdr1a-/- mouse model of colitis.Q42146204
A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapyQ42169041
Human bone marrow contains a subset of quiescent early memory CD8(+) T cells characterized by high CD127 expression and efflux capacity.Q42186951
Expression levels of P-glycoprotein in peripheral blood CD8+ T lymphocytes from HIV-1-infected patients on antiretroviral therapyQ42236859
Efficient trafficking of MDR1/P-glycoprotein to apical canalicular plasma membranes in HepG2 cells requires PKA-RIIalpha anchoring and glucosylceramideQ42416387
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.Q42417394
Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoproteinQ42464101
Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domainsQ42800313
Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody.Q42834373
Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group studyQ43806484
Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic miceQ43843005
Modulation of P-glycoprotein but not MRP1- or BCRP-mediated drug resistance by LY335979.Q44231781
Influence of MDR1 C1236T polymorphism on lopinavir plasma concentration and virological response in HIV-1-infected childrenQ44247691
Intracellular concentration of protease inhibitors in HIV-1-infected patients: correlation with MDR-1 gene expression and low dose of ritonavirQ44261692
Immunological effects of taxol and adryamicin in breast cancer patients.Q45661616
Restoration of P-glycoprotein function is involved in the increase of natural killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individualsQ45739708
Abnormal expression of a 170-kilodalton P-glycoprotein encoded by MDR1 gene, a metabolically active efflux pump, in CD4+ and CD8+ T cells from patients with human immunodeficiency virus type 1 infectionQ45766786
miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1.Q46037039
An assessment of P-glycoprotein expression and activity in peripheral blood lymphocytes of transplant candidatesQ46420437
Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions.Q46430249
Anti-P-glycoprotein antibody-induced apoptosis of activated peripheral blood lymphocytes: a possible role of P-glycoprotein in lymphocyte survivalQ46846341
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.Q47231170
Differential activity of P-glycoprotein in normal blood lymphocyte subsetsQ47801610
Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sitesQ47922050
MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrierQ48116760
P433issue12
P304page(s)e1499388
P577publication date2018-09-06
P1433published inOncoImmunologyQ18026500
P1476titleMDR1 in immunity: friend or foe?
P478volume7