NBOMes-Highly Potent and Toxic Alternatives of LSD

scientific article published on 26 February 2020

NBOMes-Highly Potent and Toxic Alternatives of LSD is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FNINS.2020.00078
P932PMC publication ID7054380
P698PubMed publication ID32174803

P50authorJolanta B ZawilskaQ89104874
P2093author name stringPiotr Adamowicz
Monika Kacela
P2860cites workSerotonin syndromeQ94024529
Changes in neuronal activity in rat primary cortical cultures induced by illicit drugs and new psychoactive substances (NPS) following prolonged exposure and washout to mimic human exposure scenariosQ91948144
Use of new and uncommon synthetic psychoactive drugs among a nationally representative sample in the United States, 2005-2017Q92184134
Neurochemical and Behavioral Profiling in Male and Female Rats of the Psychedelic Agent 25I-NBOMeQ92504062
Fatalities related to new psychoactive substances in Singapore-A case seriesQ92506312
Simultaneous analysis of 2Cs, 25-NBOHs, 25-NBOMes and LSD in seized exhibits using liquid chromatography-tandem mass spectrometry: A targeted approachQ92987979
Hallucinogen-Like Action of the Novel Designer Drug 25I-NBOMe and Its Effect on Cortical Neurotransmitters in RatsQ93118570
MS-Based Molecular Networking of Designer Drugs as an Approach for the Detection of Unknown Derivatives for Forensic and Doping Applications: A Case of NBOMe DerivativesQ93126601
Abuse potential of 2-(4-iodo-2, 5-dimethoxyphenyl)N-(2-methoxybenzyl)ethanamine (25INBOMe); in vivo and ex vivo approachesQ91623439
A novel designer drug, 25N-NBOMe, exhibits abuse potential via the dopaminergic system in rodentsQ91675489
Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptorsQ91811794
25C-NBOMe, a Novel Designer Psychedelic, Induces Neurotoxicity 50 Times More Potent Than Methamphetamine In VitroQ91927918
High-performance liquid chromatography with tandem mass spectrometry for the determination of nine hallucinogenic 25-NBOMe designer drugs in urine specimensQ37630040
2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe): clinical case with unique confirmatory testing.Q37633498
Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic deathQ37672302
2C-I-NBOMe, an "N-bomb" that kills with "Smiles". Toxicological and legislative aspectsQ38208426
Prevalence of use and acute toxicity associated with the use of NBOMe drugsQ38346439
Fatal Intoxications with 25B-NBOMe and 25I-NBOMe in Indiana During 2014.Q38588257
A Case Review of the First Analytically Confirmed 25I-NBOMe-Related Death in Washington StateQ38588258
New Drugs of Abuse and Withdrawal SyndromesQ38614202
Experimental Study on the Postmortem Redistribution of the Substituted Phenethylamine, 25B-NBOMeQ38712647
NBOMe hallucinogenic drug exposures reported to the Danish Poison Information CentreQ38752840
Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") HallucinogensQ39093171
Non-traumatic rhabdomyolysis: Background, laboratory features, and acute clinical management.Q39149853
25C-NBOMe and 25I-NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high-resolution mass spectrometryQ39569585
Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC-MS/MS in case of severe intoxicationsQ39591988
25I-NBOMe related death in Australia: a case reportQ41278661
An evaluation of 25B-, 25C-, 25D-, 25H-, 25I- and 25T2-NBOMe via LC-MS-MS: method validation and analyte stabilityQ43407752
An investigation of the stability of emerging new psychoactive substancesQ44276254
The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in ratsQ44508158
Severe poisoning after self-reported use of 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine, a novel substituted amphetamine: a case seriesQ45013644
Lysergic acid diethylamide and [-]-2,5-dimethoxy-4-methylamphetamine increase extracellular glutamate in rat prefrontal cortexQ45056353
Effect of Hallucinogens on Unconditioned BehaviorQ45279141
Metabolic fate and detectability of the new psychoactive substances 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25B-NBOMe) and 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25C-NBOMe) in human andQ46450715
Retrospective demonstration of 25I-NBOMe acute poisoning using hair analysisQ47181383
A Validated Method for the Detection of 32 Bath Salts in Oral FluidQ47686894
Death after 25C-NBOMe and 25H-NBOMe consumptionQ47891412
Development of a quantitative approach in blood plasma for low-dosed hallucinogens and opioids using LC-high resolution mass spectrometryQ47974432
Case series: toxicity from 25B-NBOMe--a cluster of N-bomb casesQ48069477
Detection of 25C-NBOMe in Three Related CasesQ48721685
Metabolic Fate of Hallucinogenic NBOMesQ49148401
Human cytochrome P450 kinetic studies on six N-2-methoxybenzyl (NBOMe)-derived new psychoactive substances using the substrate depletion approachQ49579124
NBOMe: new potent hallucinogens--pharmacology, analytical methods, toxicities, fatalities: a reviewQ26781727
25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drugQ26822943
Toxicities associated with NBOMe ingestion-a novel class of potent hallucinogens: a review of the literatureQ26865329
Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonistsQ28265476
The activation of 5-HT receptors in prefrontal cortex enhances dopaminergic activityQ28281024
Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortexQ28567004
Serotonin and HallucinogensQ29399981
LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptorQ30484494
NBOMe and 2C substitute phenylethylamine exposures reported to the National Poison Data SystemQ30969880
Serotonin 2A receptor agonist binding in the human brain with [¹¹C]Cimbi-36.Q33851479
Theoretical studies on the interaction of partial agonists with the 5-HT2A receptorQ34024760
Hallucinogenic drug interactions at human brain 5-HT2 receptors: implications for treating LSD-induced hallucinogenesisQ34041519
Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET.Q34144415
G protein- and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulationsQ34160474
Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogensQ34167036
Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agentsQ34262666
25C-NBOMe--new potent hallucinogenic substance identified on the drug market.Q34300481
A case of 25I-NBOMe (25-I) intoxication: a new potent 5-HT2A agonist designer drugQ34331924
Severe clinical toxicity associated with analytically confirmed recreational use of 25I-NBOMe: case seriesQ34348317
Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch responseQ34369264
Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.Q34396223
The NBOMe hallucinogenic drug series: Patterns of use, characteristics of users and self-reported effects in a large international sampleQ34406732
Near fatal intoxication with the novel psychoactive substance 25C-NBOMeQ34417353
Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats.Q34435965
"My friend said it was good LSD": a suicide attempt following analytically confirmed 25I-NBOMe ingestionQ34453002
N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine AnaloguesQ34455931
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist actionQ34485906
Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs).Q34491433
Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligandsQ34555941
Analysis of new designer drugs in post-mortem blood using high-resolution mass spectrometry.Q35536635
Analysis of 25I-NBOMe, 25B-NBOMe, 25C-NBOMe and Other Dimethoxyphenyl-N-[(2-Methoxyphenyl) Methyl]Ethanamine Derivatives on Blotter PaperQ36062676
Identification of Metabolite Biomarkers of the Designer Hallucinogen 25I-NBOMe in Mouse Hepatic Microsomal Preparations and Human Urine Samples Associated with Clinical IntoxicationQ36062680
Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in RatsQ37306537
Locomotor and discriminative stimulus effects of four novel hallucinogens in rodents.Q50627353
Metabolic Profile Determination of NBOMe Compounds Using Human Liver Microsomes and Comparison with Findings in Authentic Human Blood and Urine.Q50673261
Bad trip due to 25I-NBOMe: a case report from the EU project SPICE II plus.Q50674127
Pathological findings in 2 cases of fatal 25I-NBOMe toxicity.Q51166112
Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").Q52249429
Neurotoxicity screening of new psychoactive substances (NPS): Effects on neuronal activity in rat cortical cultures using microelectrode arrays (MEA).Q52639645
LC-high resolution-MS/MS for identification of 69 metabolites of the new psychoactive substance 1-(4-ethylphenyl-)-N-[(2-methoxyphenyl)methyl] propane-2-amine (4-EA-NBOMe) in rat urine and human liver S9 incubates and comparison of its screening powQ52760538
Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens.Q52867769
Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH.Q53063534
Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats.Q53080749
A fatal poisoning involving 25C-NBOMe.Q53555634
25C-NBOMe Ingestion.Q55383928
Effects of exposure to 5-MeO-DIPT during adolescence on brain neurotransmission and neurotoxicity in adult ratsQ64388191
Studies on the metabolism and toxicological detection of the new psychoactive designer drug 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe) in human and rat urine using GC-MS, LC-MS(n), and LC-HR-MS/MSQ85459796
NBOMe designer drug exposures reported to Texas poison centersQ87554122
Two cases of severe intoxication associated with analytically confirmed use of the novel psychoactive substances 25B-NBOMe and 25C-NBOMeQ87778674
Drug Recognition Evaluation and Chemical Confirmation of a 25C-NBOMe-Impaired DriverQ89414093
In vitro phase I metabolism of three phenethylamines 25D-NBOMe, 25E-NBOMe and 25N-NBOMe using microsomal and microbial modelsQ89416109
Nano liquid chromatography-high-resolution mass spectrometry for the identification of metabolites of the two new psychoactive substances N-(ortho-methoxybenzyl)-3,4-dimethoxyamphetamine and N-(ortho-methoxybenzyl)-4-methylmethamphetamineQ90367888
5-Methoxy-α-methyltryptamine (5-MeO-AMT), a tryptamine derivative, induces head-twitch responses in mice through the activation of serotonin receptor 2a in the prefrontal cortexQ90573484
Mix of new substances psychoactive, NPS, found in blotters sold in two Colombian citiesQ90591689
Metabolic profile determination of 25N-NBOMe in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometryQ90847102
Clinical and Toxicological Profile of NBOMes: A Systematic ReviewQ90868866
DARK Classics in Chemical Neuroscience: NBOMesQ90969018
2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe) and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine (25C-NBOMe) induce adverse cardiac effects in vitro and in vivoQ91112345
Gas Chromatography-Mass Spectrometry Method for the Quantitative Identification of 23 New Psychoactive Substances in Blood and UrineQ91277413
25B-NBOMe, a novel N-2-methoxybenzyl-phenethylamine (NBOMe) derivative, may induce rewarding and reinforcing effects via a dopaminergic mechanism: Evidence of abuse potentialQ91364907
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectlysergic acid diethylamideQ23118
P304page(s)78
P577publication date2020-02-26
P1433published inFrontiers in NeuroscienceQ2177807
P1476titleNBOMes-Highly Potent and Toxic Alternatives of LSD
P478volume14