Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases

scientific article published on 02 August 2018

Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JACS.8B05283
P932PMC publication ID6400064
P698PubMed publication ID30028600

P50authorKabirul IslamQ88336855
P2093author name stringBabu Sudhamalla
Simran Arora
Sinan Wang
Sam Kavoosi
Valerie Snyder
P2860cites workThe obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylaseQ24299948
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2Q24306181
Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidationQ24311603
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1Q24316558
Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenaseQ24614496
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineQ24614582
Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNAQ24622718
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAQ24632387
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesQ24632807
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cellsQ24683296
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesQ26829985
Chemical methods for decoding cytosine modifications in DNAQ27003288
Staurosporine-Derived Inhibitors Broaden the Scope of Analog-Sensitive Kinase TechnologyQ27680486
Crystal structure of the RNA demethylase ALKBH5 from zebrafishQ27681862
Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylasesQ27683568
Structural insight into substrate preference for TET-mediated oxidationQ27702550
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferationQ28255707
Expanding chemical biology of 2-oxoglutarate oxygenasesQ28268841
A chemical switch for inhibitor-sensitive alleles of any protein kinaseQ29614785
Active demethylation of the paternal genome in the mouse zygoteQ33901068
Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.Q34029463
Active DNA demethylation: many roads lead to Rome.Q34129576
Magic bullets for protein kinasesQ34221212
Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probesQ34443912
Generation of a conditional analog-sensitive kinase in human cells using CRISPR/Cas9-mediated genome engineeringQ36239605
TET family proteins: oxidation activity, interacting molecules, and functions in diseasesQ36668364
Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C).Q36744726
FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.Q36856390
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cellsQ37543786
Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling.Q37743269
Oxygen, epigenetic signaling, and the evolution of early lifeQ38085926
Allele-specific chemical genetics: concept, strategies, and applicationsQ38273198
Engineering the substrate specificity of ADP-ribosyltransferases for identifying direct protein targetsQ41153612
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongationQ41218811
Studies on the catalytic domains of multiple JmjC oxygenases using peptide substratesQ41520051
Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancerQ41701650
Design of allele-specific protein methyltransferase inhibitorsQ43804780
Chemical genetics: where genetics and pharmacology meetQ46192463
Selective inhibition of factor inhibiting hypoxia-inducible factorQ46507004
Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.Q48180112
A rapid mass spectrometric method for the measurement of catalytic activity of ten-eleven translocation enzymes.Q50925680
Engineering Biological C-H Functionalization Leads to Allele-Specific Regulation of Histone Demethylases.Q51144415
Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity.Q52718797
Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope TracingQ57376743
A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-sulfonyl tetrazoles from azides and sulfonyl cyanidesQ84545888
Modular synthesis of cell-permeating 2-ketoglutarate estersQ87193254
P433issue32
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)10263-10269
P577publication date2018-08-02
P1433published inJournal of the American Chemical SocietyQ898902
P1476titleComplementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases
P478volume140

Reverse relations

cites work (P2860)
Q58615492Selectivity and Promiscuity in TET-mediated oxidation of 5-methylcytosine in DNA and RNA
Q64231565Unleashing the Synthetic Power of Plant Oxygenases: From Mechanism to Application

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