Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer

scientific article published on 28 September 2019

Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS20194826
P932PMC publication ID6801932
P698PubMed publication ID31569391

P50authorAsfar S AzmiQ37368661
Steve KimQ90381570
P2093author name stringWilliam Senapedis
Amro Aboukameel
Philip A Philip
Yosef Landesman
Erkan Baloglu
Husain Y Khan
Anteneh Tesfaye
Rachel Sexton
Zaid Mahdi
Rafic Beydoun
Rahman Chaudhury
P2860cites workRAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancerQ27316858
Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignanciesQ27712238
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
Non-coding RNAs and gastric cancerQ33594919
Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trialsQ33636554
Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAsQ33729026
Epidemiology of gastric cancerQ33788193
The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and DrosophilaQ33914384
Nuclear export mediated regulation of microRNAs: potential target for drug interventionQ34204130
Epstein-barr virus vaccinesQ35053650
The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancersQ35906685
Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in miceQ36675242
XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myelomaQ37684621
Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell deathQ37694722
Epstein-Barr Virus (EBV)-associated gastric carcinomaQ38076138
Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasoneQ38738390
Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathwayQ38975542
Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cellsQ39268886
Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell lineQ40675789
Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute LeukemiaQ41087485
The CRM1 nuclear export protein in normal development and disease.Q41860863
An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrenceQ42282712
Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration.Q43907188
Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian CancerQ46112984
Balancing the yin and yang of SINE.Q48144183
Therapeutic Targeting of Nuclear Export Inhibition in Lung CancerQ48743003
Risk and epidemiological time trends of gastric cancer in Lynch syndrome carriers in the Netherlands.Q51604498
Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma.Q52612178
Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand MāoriQ52626311
[Radiation response enhanced by inhibition of XPO1 in preclinical rectal cancer models].Q53003636
Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer.Q53686273
The Role of Exportin-5 in MicroRNA Biogenesis and Cancer.Q54112610
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.Q55085029
Isolation of spheroid-forming single cells from gastric cancer cell lines: enrichment of cancer stem-like cellsQ57052578
Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressorQ58774746
E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancerQ58805932
The past, present, and future of CRM1/XPO1 inhibitorsQ64107227
The XPO1 Inhibitor Selinexor Inhibits Translation and Enhances the Radiosensitivity of Glioblastoma Cells Grown andQ64389500
Gastric Cancer, Version 3.2016, NCCN Clinical Practice Guidelines in OncologyQ88473347
Comparative Molecular Analyses of Esophageal Squamous Cell Carcinoma, Esophageal Adenocarcinoma, and Gastric AdenocarcinomaQ88984924
Radical gastrectomy for gastric cancer at Tata Memorial HospitalQ90786022
Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agentsQ90968133
Lifestyle chemical carcinogens associated with mutations in cell cycle regulatory genes increases the susceptibility to gastric cancer riskQ91413516
XPO1 Inhibitor Approved for Multiple MyelomaQ92091008
A Heterochromatin-Specific RNA Export Pathway Facilitates piRNA ProductionQ92525278
MiR-876-5p regulates gastric cancer cell proliferation, apoptosis and migration through targeting WNT5A and MITFQ92571971
Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4)Q93080677
Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-ASQ93174208
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue19
P577publication date2019-09-28
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleTargeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer
P478volume20

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cites work (P2860)
Q99551845Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements
Q92442190Targeting XPO1 and PAK4 in 8505C Anaplastic Thyroid Cancer Cells: Putative Implications for Overcoming Lenvatinib Therapy Resistance
Q101564368The nuclear export protein XPO1 - from biology to targeted therapy

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