Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease

scientific article published on 08 December 2018

Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00109-018-1727-5
P698PubMed publication ID30535867

P50authorMonica AcostaQ38799077
Ilva D. RupenthalQ54195935
Jie ZhangQ59544796
Odunayo O MugishoQ90285258
Sarah J BouldQ114291013
P2093author name stringHelen V Danesh-Meyer
Colin R Green
David M Squirrell
P2860cites workRanibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year resultsQ24633874
Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.Q28583917
Thioredoxin-interacting protein links oxidative stress to inflammasome activationQ29614471
Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.Q30356505
Usefulness of the vitreous fluid analysis in the translational research of diabetic retinopathyQ34426246
Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?Q34482628
Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trialsQ35003936
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannelsQ35024390
Macular edema. A complication of diabetic retinopathyQ36601960
Connexin and pannexin hemichannels in inflammatory responses of glia and neuronsQ36769898
Neuronal and glial cell abnormality as predictors of progression of diabetic retinopathyQ36952309
Inflammation in diabetic retinopathyQ37884176
A key role for connexin hemichannels in spreading ischemic brain injuryQ38061437
The NLRP3 Inflammasome and its Role in Age-Related Macular DegenerationQ38596848
Connexin43 in retinal injury and diseaseQ38598207
Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeabilityQ38617017
NLRP3 Is Involved in Ischemia/Reperfusion InjuryQ38782148
Role of Hemichannels in CNS Inflammation and the Inflammasome PathwayQ38796322
Connexins and their channels in inflammationQ38888995
Risk of geographic atrophy in age-related macular degeneration patients treated with intravitreal anti-VEGF agentsQ38975099
Connexin43 Mimetic Peptide Improves Retinal Function and Reduces Inflammation in a Light-Damaged Albino Rat ModelQ39525664
Role of inflammation in the pathogenesis of diabetic retinopathyQ41012127
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.Q41131251
Connexin hemichannel blockade improves outcomes in a model of fetal ischemiaQ42633519
Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration.Q42832944
A flow cytometric analysis of vitreous inflammatory cells in patients with proliferative diabetic retinopathyQ42911116
Immunolocalization of gap junction protein connexin43 (GJA1) in the human retina and optic nerve.Q43106752
Connexin 43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury.Q46467494
Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes.Q46774822
Cytokines in the vitreous of patients with proliferative diabetic retinopathyQ46851731
Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor RetinasQ47176174
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological ImplicationsQ47770967
NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.Q48151440
Sustained intravitreal delivery of connexin43 mimetic peptide by poly(D,L-lactide-co-glycolide) acid micro- and nanoparticles--Closing the gap in retinal ischaemiaQ48416361
Characterizing the mode of action of extracellular Connexin43 channel blocking mimetic peptides in an in vitro ischemia injury model.Q48438781
Systemic Administration of Connexin43 Mimetic Peptide Improves Functional Recovery after Traumatic Spinal Cord Injury in Adult RatsQ48512809
The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP releaseQ48595218
Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemiaQ48654177
The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.Q49169179
Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia.Q50250404
Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury.Q50484003
Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds.Q50493571
Glial reactivity, an early feature of diabetic retinopathy.Q50511477
Targeting connexin43 expression accelerates the rate of wound repair.Q52099637
Higher Numbers of Hyperreflective Foci Seen in the Vitreous on Spectral-Domain Optical Coherence Tomographic Images in Eyes with More Severe Diabetic Retinopathy.Q52871340
Intravitreal pro-inflammatory cytokines in non-obese diabetic mice: Modelling signs of diabetic retinopathyQ58723006
Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathyQ83625730
P433issue2
P921main subjectdiabetic retinopathyQ631361
P304page(s)215-229
P577publication date2018-12-08
P1433published inJournal of Molecular MedicineQ6295593
P1476titleConnexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease
P478volume97

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cites work (P2860)
Q90638439Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage
Q98577928Fast and Automated Hyperreflective Foci Segmentation Based on Image Enhancement and Improved 3D U-Net in SD-OCT Volumes with Diabetic Retinopathy

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