FOXO transcription factors in non-alcoholic fatty liver disease

scientific article published on 01 September 2017

FOXO transcription factors in non-alcoholic fatty liver disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.LIVRES.2017.11.004
P932PMC publication ID6051710
P698PubMed publication ID30034912

P2093author name stringX Charlie Dong
P2860cites workSilent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activityQ24298021
The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcriptionQ24301955
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylationQ24534597
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed miceQ24654808
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylationQ24674602
Long live FOXO: unraveling the role of FOXO proteins in aging and longevityQ26773901
Redox regulation of FoxO transcription factorsQ26799843
FOXO transcription factors: key regulators of cellular quality controlQ26851722
FOXO3: A Major Gene for Human Longevity--A Mini-ReviewQ26996592
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3aQ28210523
The FoxO codeQ28275268
SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgammaQ28301961
The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolismQ28512608
Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16Q28579390
Autophagy regulates lipid metabolismQ29547421
Forkhead transcription factors: key players in development and metabolismQ29618804
The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injuryQ33840005
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulationQ34089899
Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemiaQ34094336
Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulationQ34143516
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthQ34236816
FoxOs function synergistically to promote glucose productionQ34284954
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors.Q34339449
Insulin-dependent suppression of cholesterol 7α-hydroxylase is a possible link between glucose and cholesterol metabolismsQ39329298
FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytesQ39416732
Down-regulation of FoxO-dependent c-FLIP expression mediates TRAIL-induced apoptosis in activated hepatic stellate cellsQ39847039
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expressionQ39977199
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in miceQ40041201
FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms.Q40462000
A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscleQ40670804
Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in miceQ42056919
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasisQ42681991
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genesQ46402217
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expressionQ46955933
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liverQ48386175
The role of FOXO in the regulation of metabolism.Q54742441
Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic SteatohepatitisQ57659886
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophagesQ34479950
Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptakeQ34559836
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cellsQ34615778
Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase geneQ34800558
Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysisQ34981792
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.Q35049218
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in miceQ35565619
A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolismQ35630807
Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemiaQ35661144
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver functionQ35750935
Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice.Q35860656
FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1cQ36016844
Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance.Q36109222
The new biology of diabetesQ36113537
Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cellsQ36193081
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilizationQ36584799
FOXO animal models reveal a variety of diverse roles for FOXO transcription factorsQ37129810
Aberrant Forkhead box O1 function is associated with impaired hepatic metabolismQ37149810
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6Q37163041
FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expressionQ37226067
Genetics. Simple genetics for a complex diseaseQ37339090
Hepatic insulin resistance directly promotes formation of cholesterol gallstonesQ37366384
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages.Q37400789
CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT.Q37637287
Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO ProteinsQ37693826
FOXO transcription factors protect against the diet-induced fatty liver diseaseQ37704641
Foxo1 integrates insulin signaling with mitochondrial function in the liverQ37715192
Regulation of FoxO transcription factors by acetylation and protein-protein interactionsQ37852172
Forkhead box class O transcription factors in liver function and diseaseQ38121578
FOXO in aging: did evolutionary diversification of FOXO function distract it from prolonging life?Q38154207
Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across speciesQ39094521
FoxO integration of insulin signaling with glucose and lipid metabolism.Q39141439
AKT/PKB Signaling: Navigating the NetworkQ39255027
Mechanisms of hepatic stellate cell activationQ39294420
P433issue3
P921main subjectmetabolic dysfunction–associated steatotic liver diseaseQ1546498
non-alcoholic fatty liverQ66299798
P304page(s)168-173
P577publication date2017-09-01
P1476titleFOXO transcription factors in non-alcoholic fatty liver disease
P478volume1

Reverse relations

cites work (P2860)
Q92637772A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries
Q92240820Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis
Q96167082Tamoxifen induces fatty liver disease in breast cancer through the MAPK8/FoxO pathway

Search more.