Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

scientific article published on 18 March 2020

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00204-020-02695-5
P932PMC publication ID7225201
P698PubMed publication ID32185416

P50authorMatthias DiemQ64034479
Shuo YangQ90415887
Jakob D H LiuQ90415889
Chris OostenbrinkQ30505204
P2093author name stringJacques Vervoort
Ivonne M C M Rietjens
Sebastiaan Wesseling
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Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic ApplicationsQ37579509
Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1'-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells.Q39988841
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Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling.Q46565082
Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes.Q46890644
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P577publication date2020-03-18
P1433published inArchives of ToxicologyQ635837
P1476titleCellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

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