Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

scientific article published on 17 March 2020

Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS21062048
P932PMC publication ID7139345
P698PubMed publication ID32192079

P50authorKyu Yun JangQ90195005
Lokendra ChandQ90461419
P2093author name stringHyun Beak Shin
Yeon Jun Jeong
Suvesh Munakarmi
P2860cites workMolecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Q23919668
The Role of Oxidative Stress and Antioxidants in Liver DiseasesQ26779146
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 geneQ28372162
Nrf2:INrf2 (Keap1) signaling in oxidative stressQ29615712
Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factorQ33629414
Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in miceQ33694925
Wnt-β-catenin signaling protects against hepatic ischemia and reperfusion injury in miceQ33856371
Mechanisms of liver cell injuryQ33870222
Chlorinated methanes and liver injury: highlights of the past 50 yearsQ33932099
2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathwaysQ34013947
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in miceQ34302937
The involvement of Kupffer cells in carbon tetrachloride toxicity.Q50783765
Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factorsQ50947559
Chrysin modulates ethanol metabolism in Wistar rats: a promising role against organ toxicities.Q51469703
Diterpenoid trigonoreidon B isolated from Trigonostemon reidioides alleviates inflammation in models of LPS-stimulated murine macrophages and inflammatory liver injury in mice.Q52595748
3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells.Q53629560
Acute liver failureQ56430379
3,3'-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosisQ58560864
A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutationsQ58718413
3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitroQ58787947
The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic ApproachesQ60916607
Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stressQ80032521
The role of Kupffer cells in carbon tetrachloride intoxication in miceQ84353814
Investigation of the hepatoprotective effects of Sesame (Sesamum indicum L.) in carbon tetrachloride-induced liver toxicityQ84853967
Protective effect of the total flavonoids from Apocynum venetum L. on carbon tetrachloride-induced hepatotoxicity in vitro and in vivoQ88062926
Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic ratsQ88157720
Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in miceQ89380486
Liver regeneration: from myth to mechanismQ34354926
The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2.Q34558568
Natural indoles, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), attenuate staphylococcal enterotoxin B-mediated liver injury by downregulating miR-31 expression and promoting caspase-2-mediated apoptosisQ35113115
3,3'-Diindolylmethane attenuates LPS-mediated acute liver failure by regulating miRNAs to target IRAK4 and suppress Toll-like receptor signallingQ35286427
Indigofera oblongifolia Prevents Lead Acetate-Induced Hepatotoxicity, Oxidative Stress, Fibrosis and Apoptosis in Rats.Q36071277
Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidationQ36113514
Nitric oxide production and signaling in inflammation.Q36230417
Pathophysiological basis for antioxidant therapy in chronic liver diseaseQ36316956
Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α.Q36775015
Glycyrrhizic acid attenuates CCl₄-induced hepatocyte apoptosis in rats via a p53-mediated pathwayQ36975008
Protective Effects of Silymarin, Alone or in Combination with Chlorogenic Acid and/or Melatonin, Against Carbon Tetrachloride-induced Hepatotoxicity.Q37149008
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administrationQ37381842
Biologically active products of stimulated liver macrophages (Kupffer cells).Q37893914
Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitisQ38087926
The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liverQ38113967
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.Q38172752
Adenosine induces cell cycle arrest and apoptosis via cyclinD1/Cdk4 and Bcl-2/Bax pathways in human ovarian cancer cell line OVCAR-3.Q39205696
Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in miceQ39423783
Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expressionQ39434294
Parboiled Germinated Brown Rice Protects Against CCl4-Induced Oxidative Stress and Liver Injury in RatsQ40834320
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.Q40933400
Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.Q41093247
Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.Q41265860
Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in miceQ41597881
Hepatoprotective effect of methanolic Tanacetum parthenium extract on CCl4-induced liver damage in ratsQ41678818
Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachlorideQ41905768
N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway.Q41966957
Carbon tetrachloride toxicity as a model for studying free-radical mediated liver injuryQ42201531
Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathwayQ42722591
Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old ratsQ42939207
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.Q43242090
Cytokine expression in three mouse models of experimental hepatitisQ44145437
Multiple molecular targets of indole-3-carbinol, a chemopreventive anti-estrogen in breast cancerQ44304562
Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of γ-irradiated rat.Q46565261
Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in miceQ46901581
Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in miceQ46965726
Nrf2, the Master Regulator of Anti-Oxidative ResponsesQ47250925
Hepatoprotective effect of fraxin against carbon tetrachloride-induced hepatotoxicity in vitro and in vivo through regulating hepatic antioxidant, inflammation response and the MAPK-NF-κB signaling pathwayQ47784525
Hepatoprotective evaluation of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: In vitro and in vivo studiesQ50236864
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P577publication date2020-03-17
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleIndole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress
P478volume21

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Q98289743Targeting micro-RNAs by natural products: a novel future therapeutic strategy to combat cancercites workP2860

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