Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway

scientific article published on 03 October 2019

Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41419-019-1904-7
P932PMC publication ID6776644
P698PubMed publication ID31582734

P2093author name stringXi Chen
Wei Zhang
Lan Tang
Mo Chen
Jianzhong Chen
Erman Chen
Guangyao Jiang
Chenyi Ye
Jinwei Lu
Kai Hang
Qianhai Ding
Weiduo Hou
Rongxin He
Baojian Hong
P2860cites workGremlin2 Suppression Increases the BMP-2-Induced Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Via the BMP-2/Smad/Runx2 Signaling Pathway.Q51687090
An asymmetric chitosan scaffold for tendon tissue engineering: In vitro and in vivo evaluation with rat tendon stem/progenitor cells.Q52573611
Concentration-dependent, dual roles of IL-10 in the osteogenesis of human BMSCs via P38/MAPK and NF-κB signaling pathways.Q52598925
IL-37 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption in vivo.Q52870865
Elevated serum levels of Interleukin-37 are associated with inflammatory cytokines and disease activity in rheumatoid arthritis.Q53285571
Treatment of failed allograft prosthesis composites used for hip arthroplasty in the setting of severe proximal femoral bone defects.Q53671377
Bone marrow mesenchymal stem cells, platelet-rich plasma and nanohydroxyapatite-type I collagen beads were integral parts of biomimetic bone substitutes for bone regeneration.Q54302987
COMP-angiopoietin 1 increases proliferation, differentiation, and migration of stem-like cells through Tie-2-mediated activation of p38 MAPK and PI3K/Akt signal transduction pathways.Q54306421
IL-37 protects against obesity-induced inflammation and insulin resistance.Q54325530
Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils.Q55514829
Knockdown of FOXA2 enhances the osteogenic differentiation of bone marrow-derived mesenchymal stem cells partly via activation of the ERK signalling pathwayQ58799586
Sal B targets TAZ to facilitate osteogenesis and reduce adipogenesis through MEK-ERK pathwayQ64055454
Elevated serum and synovial fluid levels of interleukin-37 in patients with rheumatoid arthritis: Attenuated the production of inflammatory cytokinesQ85564257
The osteoregenerative effects of platelet-derived growth factor BB cotransplanted with mesenchymal stem cells, loaded on freeze-dried mineral bone block: a pilot study in dog mandibleQ87625012
Alendronate delivery on amino modified mesoporous bioactive glass scaffolds to enhance bone regeneration in osteoporosis ratsQ88453758
Stimulation of calvarial bone healing with human bone marrow stromal cells versus inhibition with adipose-tissue stromal cells on nanostructured β-TCP-collagenQ89191676
IL-8 Enhances Therapeutic Effects of BMSCs on Bone Regeneration via CXCR2-Mediated PI3k/Akt Signaling PathwayQ90284318
Layer-by-layer nanofiber-enabled engineering of biomimetic periosteum for bone repair and reconstructionQ91127899
Treatment of posttraumatic bone defects of the forearm with vascularized fibular grafts. Follow up after fourteen yearsQ91464178
Functionalization of Silk Fibroin Electrospun Scaffolds via BMSC Affinity Peptide Grafting through Oxidative Self-Polymerization of Dopamine for Bone RegenerationQ91688094
Cav 1.2 regulates osteogenesis of bone marrow-derived mesenchymal stem cells via canonical Wnt pathway in age-related osteoporosisQ92236523
Osteogenesis activity of isocoumarin a through the activation of the PI3K-Akt/Erk cascade-activated BMP/RUNX2 signaling pathwayQ92953438
IL-33 guides osteogenesis and increases proliferation and pluripotency marker expression in dental stem cellsQ93087699
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathwayQ24305237
IL-37 is a fundamental inhibitor of innate immunityQ28295265
Akt promotes BMP2-mediated osteoblast differentiation and bone developmentQ28511143
IL-37: a new anti-inflammatory cytokine of the IL-1 family.Q30155438
The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiationQ33327777
Zero-order controlled release of BMP2-derived peptide P24 from the chitosan scaffold by chemical grafting modification technique for promotion of osteogenesis in vitro and enhancement of bone repair in vivoQ33588145
Risk of osteoporotic fracture in a large population-based cohort of patients with rheumatoid arthritisQ33648507
TNFα and IL-1β influence the differentiation and migration of murine MSCs independently of the NF-κB pathwayQ34255259
Interleukin-37 is increased in ankylosing spondylitis patients and associated with disease activity.Q35068107
Mechano-growth factor accelerates the proliferation and osteogenic differentiation of rabbit mesenchymal stem cells through the PI3K/AKT pathwayQ35542828
Plasma Interleukin-37 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1/Th2/Th17-Related CytokinesQ36083136
Beneficial effects of IL-37 after spinal cord injury in miceQ36563200
Overexpression of HSPA1A enhances the osteogenic differentiation of bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signaling pathwayQ36986217
HMGB1 promotes the secretion of multiple cytokines and potentiates the osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway.Q37582089
Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses.Q37599811
The development of tissue-engineered bone of different origin through endochondral and intramembranous ossification following the implantation of mesenchymal stem cells and osteoblasts in a murine model.Q38349968
Carbon Nanotube Reinforced Collagen/Hydroxyapatite Scaffolds Improve Bone Tissue Formation In Vitro and In VivoQ38723009
A protective role of IL-37 in cancer: a new hope for cancer patientsQ38791428
IL-37 mediates the antitumor activity in renal cell carcinomaQ38828113
The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case StudyQ38831693
Microenvironmental Views on Mesenchymal Stem Cell Differentiation in AgingQ38865555
Bradykinin regulates osteoblast differentiation by Akt/ERK/NFκB signaling axisQ38995230
The recruitment of two consecutive and different waves of host stem/progenitor cells during the development of tissue-engineered bone in a murine model.Q39764443
Interleukin-37 Ameliorates Coxsackievirus B3-induced Viral Myocarditis by Modulating the Th17/Regulatory T cell Immune ResponseQ40332936
Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammationQ40561232
Local delivery of HMGB1 in gelatin sponge scaffolds combined with mesenchymal stem cell sheets to accelerate fracture healingQ41091893
Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/β-catenin signaling pathway.Q42261458
Magnetic Nanocomposite Hydrogel for Potential Cartilage Tissue Engineering: Synthesis, Characterization, and Cytocompatibility with Bone Marrow Derived Mesenchymal Stem CellsQ46683848
IGFBP7 regulates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells via Wnt/β-catenin signaling pathwayQ47292269
Repair of Calvarial Bone Defect Using Jarid1a-Knockdown Bone Mesenchymal Stem Cells in Rats.Q47679202
Synergistic effect of strontium, bioactive glass and nano-hydroxyapatite promotes bone regeneration of critical-sized radial bone defectsQ50422362
IL-6 is produced by adipose-derived stromal cells and promotes osteogenesis.Q50488813
IL-37 Is a Novel Proangiogenic Factor of Developmental and Pathological Angiogenesis.Q50552201
Serum Level of Interleukin-37 and Expression of Its mRNA in Ankylosing Spondylitis Patients: Possible Role in Osteoporosis.Q51003127
IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway.Q51039901
P433issue10
P304page(s)753
P577publication date2019-10-03
P1433published inCell Death and DiseaseQ2197222
P1476titleExtracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway
P478volume10

Reverse relations

cites work (P2860)
Q99616620A novel lncRNA LNC_000052 leads to the dysfunction of osteoporotic BMSCs via the miR-96-5p-PIK3R1 axis
Q97423430Activating PIK3CA mutation promotes osteogenesis of bone marrow mesenchymal stem cells in macrodactyly
Q90746409IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer