ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface

scientific article published on 19 March 2020

ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.RA119.011192
P932PMC publication ID7212652
P698PubMed publication ID32193206

P50authorPatricia D'AmoreQ30323567
Magali Saint-GeniezQ58898025
Jinling YangQ59680727
Issahy CanoQ90468726
P2093author name stringYin-Shan Ng
Michelle E LeBlanc
Kahira L Saez-Torres
P2860cites workThe disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesionQ24300435
Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.Q27335094
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)Q28211911
Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucinQ28510561
Inflammation- and ischemia-induced shedding of venular glycocalyxQ28572410
Inflammation in atherosclerosisQ29547428
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disordersQ29615839
A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cellsQ33581409
Leukocyte-endothelial interactions in inflammationQ33819619
Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expressionQ34027281
Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skinQ34165167
Leukocyte-endothelial cell interactions in the inflammatory responseQ34633418
Shedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammationQ35601382
CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytesQ36264320
Emerging roles for ectodomain shedding in the regulation of inflammatory responsesQ36432148
The endothelium and vascular inflammation in diabetesQ36892486
Sialic acids in human health and diseaseQ36908164
Inflammation, endothelium, and coagulation in sepsisQ37011058
Contributions of inflammatory processes to the development of the early stages of diabetic retinopathyQ37084522
Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokinesQ37373049
The role of ADAM-mediated shedding in vascular biology.Q37964357
Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis.Q38650120
Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar spaceQ38994499
Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alphaQ39797126
Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skinQ40158221
Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1).Q40342802
Pervanadate activation of intracellular kinases leads to tyrosine phosphorylation and shedding of syndecan-1.Q41163144
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.Q41840639
Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharideQ41847844
Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemiaQ42519962
Inhibition of glycan shedding and leukocyte-endothelial adhesion in postcapillary venules by suppression of matrixmetalloprotease activity with doxycyclineQ43244390
Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculatureQ43940033
Role of glycocalyx in leukocyte-endothelial cell adhesionQ44138368
Interleukin-6 and tumor necrosis factor-α levels in plasma and cerebrospinal fluid of term newborn infants with hypoxic–ischemic encephalopathyQ44414565
Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17).Q44524121
Pervanadate-induced shedding of the intercellular adhesion molecule (ICAM)-1 ectodomain is mediated by membrane type-1 matrix metalloproteinase (MT1-MMP).Q46613828
Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity.Q51738150
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.Q51788052
Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).Q51824970
Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction.Q52652840
Human neutrophils release their major membrane sialoprotein, leukosialin (CD43), during cell activationQ67522845
Plasma levels of cytokines in primary septic shock in humans: correlation with disease severityQ72351509
Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibitionQ73189805
P407language of work or nameEnglishQ1860
P577publication date2020-03-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface