STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer

scientific article published on 26 July 2018

STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41416-018-0188-5
P932PMC publication ID6133940
P698PubMed publication ID30046165

P50authorNatasha VitkinQ88751188
P2093author name stringAndrew Robinson
Kasra Khalaj
Nichole Peterson
Madhuri Koti
Abdi Ghaffari
Julie-Ann Francis
P2860cites workTumor-intrinsic oncogene pathways mediating immune avoidanceQ26747707
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancerQ26780387
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunityQ28509328
Molecular profiling and clinical outcome of high-grade serous ovarian cancer presenting with low- versus high-volume ascitesQ33748623
IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and ToleranceQ34512092
Unabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cellsQ34594959
Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer.Q50874203
Neoadjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor-Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy.Q53033027
Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunityQ59400485
Identification of the IGF1/PI3K/NF κB/ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancerQ35044404
A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer.Q35274995
Combinatorial strategies for the induction of immunogenic cell deathQ35535140
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and ImmunityQ35634752
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockadeQ35858368
Tumor and Host Factors Controlling Antitumor Immunity and Efficacy of Cancer ImmunotherapyQ35938555
Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphomaQ36051184
STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO ActivationQ36917725
STAT1-associated intratumoural TH1 immunity predicts chemotherapy resistance in high-grade serous ovarian cancer.Q37456596
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.Q37502349
Pharmacology and therapeutic potential of interferonsQ38000963
CXCL10 alters the tumour immune microenvironment and disease progression in a syngeneic murine model of high-grade serous ovarian cancerQ38711571
Anti-metastatic functions of type 1 interferons: Foundation for the adjuvant therapy of cancerQ38715458
Pooled Clustering of High-Grade Serous Ovarian Cancer Gene Expression Leads to Novel Consensus Subtypes Associated with Survival and Surgical OutcomesQ38747875
CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous CarcinomaQ38751550
Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon SignalingQ38801971
Systemic Immunity Is Required for Effective Cancer ImmunotherapyQ39006805
A brief review of the management of platinum-resistant-platinum-refractory ovarian cancerQ39263789
STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid LeukemiaQ39708605
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer.Q41346867
Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responsesQ41770853
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectovarian cancerQ172341
carboplatinQ415588
bites and stingsQ54911704
P304page(s)440-449
P577publication date2018-07-26
P1433published inBritish Journal of CancerQ326309
P1476titleSTING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer
P478volume119

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cites work (P2860)
Q91943250Checkpoint inhibitors in ovarian cancer: A review of preclinical data
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Q97549965Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer
Q98223086Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
Q89871427Mechanisms of Resistance to PD-1 Checkpoint Blockade
Q91776793Optimizing oncolytic virotherapy in cancer treatment
Q90087576Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild-type disease during the early disease course
Q92664085STING modulators: Predictive significance in drug discovery
Q102210856Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies
Q90479771Therapy With Carboplatin and Anti-PD-1 Antibodies Before Surgery Demonstrates Sustainable Anti-Tumor Effects for Secondary Cancers in Mice With Triple-Negative Breast Cancer
Q99576115Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer