Molecular Simulation of Oncostatin M and Receptor (OSM-OSMR) Interaction as a Potential Therapeutic Target for Inflammatory Bowel Disease

scientific article published on 04 March 2020

Molecular Simulation of Oncostatin M and Receptor (OSM-OSMR) Interaction as a Potential Therapeutic Target for Inflammatory Bowel Disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FMOLB.2020.00029
P932PMC publication ID7064634
P698PubMed publication ID32195265

P2093author name stringYan Qian
Qingqing Du
Weiwei Xue
P2860cites workGeneration and initial analysis of more than 15,000 full-length human and mouse cDNA sequencesQ24336098
The AB loop and D-helix in binding site III of human Oncostatin M (OSM) are required for OSM receptor activation.Q52365247
Computational alanine scanning mutagenesis--an improved methodological approachQ57132691
The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and miceQ58103945
Prediction of GluN2B-CT/DAPK1 Interaction by Protein⁻Peptide Docking and Molecular Dynamics SimulationQ59796192
Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease HQ62075874
End-Point Binding Free Energy Calculation with MM/PBSA and MM/GBSA: Strategies and Applications in Drug DesignQ68686427
Calculation of hot spots for protein-protein interaction in p53/PMI-MDM2/MDMX complexesQ90482786
Oncostatin M as a new diagnostic, prognostic and therapeutic target in inflammatory bowel disease (IBD)Q90521173
Oncostatin M receptor, positively regulated by SP1, promotes gastric cancer growth and metastasis upon treatment with Oncostatin MQ91695681
Elucidating the tight-binding mechanism of two oral anticoagulants to factor Xa by using induced-fit docking and molecular dynamics simulationQ91921070
HawkDock: a web server to predict and analyze the protein-protein complex based on computational docking and MM/GBSAQ92148939
Structural conservation of druggable hot spots in protein-protein interfacesQ24614979
Anti-TNF therapy: past, present and futureQ26997311
Crystal structure and functional dissection of the cytostatic cytokine oncostatin MQ27627161
An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptorQ27646869
Comparison of multiple Amber force fields and development of improved protein backbone parametersQ27861040
Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformationsQ28188949
RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suiteQ28743250
Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinementsQ29614394
Statistical potential for assessment and prediction of protein structuresQ29615145
Modeling of loops in protein structuresQ29615861
Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum modelsQ29616389
Automatic atom type and bond type perception in molecular mechanical calculationsQ29616744
Exploring protein native states and large-scale conformational changes with a modified generalized born modelQ29617088
Identification of hot-spot residues in protein-protein interactions by computational dockingQ30849432
Benchmarking and analysis of protein docking performance in Rosetta v3.2.Q33988409
Computational alanine scanning of the 1:1 human growth hormone-receptor complexQ34120440
Small-molecule inhibitors of protein-protein interactions: progressing toward the realityQ34263719
Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein InteractionsQ34481459
Pooled screening for antiproliferative inhibitors of protein-protein interactions.Q35930537
The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteinsQ36604792
Relationship between hot spot residues and ligand binding hot spots in protein-protein interfacesQ36758601
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB.Q36766916
Clinical Use of Measuring Trough Levels and Antibodies against Infliximab in Patients with Pediatric Inflammatory Bowel DiseaseQ37573910
Oncogenic protein interfaces: small molecules, big challenges.Q38195457
The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design.Q38826829
Cytokines in inflammatory bowel diseaseQ39206254
A role for oncostatin M in inflammatory bowel diseaseQ41129532
Comparative Protein Structure Modeling Using MODELLER.Q41144462
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.Q41846031
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectinflammatory bowel diseasesQ917447
P304page(s)29
P577publication date2020-03-04
P1433published inFrontiers in molecular biosciencesQ27726420
P1476titleMolecular Simulation of Oncostatin M and Receptor (OSM-OSMR) Interaction as a Potential Therapeutic Target for Inflammatory Bowel Disease
P478volume7

Search more.