Darpp-32 and t-Darpp protein products of PPP1R1B: Old dogs with new tricks

scientific article published on 12 December 2018

Darpp-32 and t-Darpp protein products of PPP1R1B: Old dogs with new tricks is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BCP.2018.12.008
P932PMC publication ID6360145
P698PubMed publication ID30552871

P50authorJamil MomandQ88979100
P2093author name stringGal Lenz
Arabo Avanes
P2860cites workPhosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neuronsQ22010952
DARPP-32: from neurotransmission to cancerQ26766237
The deaf and the dumb: the biology of ErbB-2 and ErbB-3Q28185247
Overexpression of the 32‐kilodalton dopamine and cyclic adenosine 3′,5′‐monophosphate‐regulated phosphoprotein in common adenocarcinomasQ28204963
Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitroQ28210065
Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPPQ28215053
Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slicesQ28236649
Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissueQ28250285
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1Q28259380
AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitroQ28282315
Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2Q28534553
t-Darpp Promotes Enhanced EGFR Activation and New Drug Synergies in Her2-Positive Breast Cancer CellsQ28545954
Regulation of multiple dopamine signal transduction molecules by retinoids in the developing striatumQ28566696
A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regionsQ28643908
Expression of t-DARPP mediates trastuzumab resistance in breast cancer cellsQ33743601
Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissueQ34100269
Targets of gene amplification and overexpression at 17q in gastric cancer.Q34125877
t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancerQ34156895
Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurinQ34492149
Functional diversity of protein phosphatase-1, a cellular economizer and reset buttonQ34649261
Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cellsQ34785283
High Expression of DARPP-32 in Colorectal Cancer Is Associated With Liver Metastases and Predicts Survival for Dukes A and B Patients: Results of a Pilot StudyQ35110657
DARPP-32, Jack of All Trades… Master of Which?Q35201971
DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinibQ35449387
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancerQ35600870
DARPP-32: an integrator of neurotransmissionQ35639141
Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesisQ35801261
The role of DARPP-32 in the actions of drugs of abuseQ35908686
Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesisQ36069142
Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinomaQ36205260
Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancerQ36476312
Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cellsQ36553388
DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinomaQ36625979
Phosphatidylinositide 3-kinase and protein kinase C zeta mediate retinoic acid induction of DARPP-32 in medium size spiny neurons in vitroQ36954085
Detailed structural characterization of unbound protein phosphatase 1 inhibitorsQ37105049
Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic elementQ37117317
Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistanceQ37248165
Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent mannerQ37448108
Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survivalQ37519743
COSMIC: somatic cancer genetics at high-resolutionQ37556877
Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32Q37678094
Genetics of inflammation in the gastrointestinal tract and how it can cause cancer.Q37913189
Discovery of small molecule cancer drugs: successes, challenges and opportunitiesQ37996113
t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunitQ38693444
PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K/AKT signalingQ39054981
Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers.Q39870542
Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32.Q40134685
Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1.Q40222621
Helicobacter, Inflammation, and Gastric CancerQ40760600
The involvement of DARPP-32 in the pathophysiology of schizophreniaQ41593397
t-Darpp is an elongated monomer that binds calcium and is phosphorylated by cyclin-dependent kinases 1 and 5.Q41627665
Amplification of a 280-Kilobase Core Region at the ERBB2 Locus Leads to Activation of Two Hypothetical Proteins in Breast CancerQ42249021
17beta-Estradiol promotes striatal medium size spiny neuronal maturation in vitroQ42463761
DARPP-32, a phosphoprotein enriched in dopaminoceptive neurons bearing dopamine D1 receptors: distribution in the cerebral cortex of the newborn and adult rhesus monkeyQ42482051
Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine.Q42494695
RARbeta isoform-specific regulation of DARPP-32 gene expression: an ectopic expression study in the developing rat telencephalon.Q46606149
t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer CellsQ47564225
Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro.Q48181177
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survivalQ48271519
Human t-DARPP is induced during striatal developmentQ48594946
Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitroQ48678036
DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task.Q52026697
Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas.Q54591709
DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migrationQ56815794
Study of the conformation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by fluorescence spectroscopyQ58191998
Distribution of messenger RNAs for D1 dopamine receptors and DARPP-32 in striatum and cerebral cortex of the cynomolgus monkey: relationship to D1 dopamine receptorsQ71525236
The DARPP-32 knockout mouseQ73553190
New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarraysQ77220709
Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatoQ82711553
Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding systemQ87970600
P407language of work or nameEnglishQ1860
P304page(s)71-79
P577publication date2018-12-12
P1433published inBiochemical PharmacologyQ864229
P1476titleDarpp-32 and t-Darpp protein products of PPP1R1B: Old dogs with new tricks
P478volume160

Reverse relations

cites work (P2860)
Q96136180ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation
Q90747980Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice
Q91329780Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression
Q90683211Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

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