Metformin Affects Heme Function as a Possible Mechanism of Action

scientific article published on 07 February 2019

Metformin Affects Heme Function as a Possible Mechanism of Action is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1534/G3.118.200803
P932PMC publication ID6385989
P698PubMed publication ID30554148

P50authorXiyan LiQ59704795
Xin WangQ90560598
Michael P. SnyderQ28924918
P2860cites workHaem-activated promiscuous targeting of artemisinin in Plasmodium falciparumQ22061870
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trialQ22242082
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenaseQ22251079
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMPQ22251081
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New mechanisms of metformin action: Focusing on mitochondria and the gutQ26778766
Covalently linked heme in cytochrome p4504a fatty acid hydroxylasesQ28141678
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Genetic evidence for high-altitude adaptation in TibetQ28282435
K562—A human erythroleukemic cell lineQ28302796
Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatmentQ28367120
Yeast multidrug resistance: The PDR networkQ40456793
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cellsQ40515180
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Enhanced glucose consumption in erythrocytes under mechanical stressQ41468841
Measurement of Heme ConcentrationQ42856098
Subcellular distribution of metformin in rat liverQ45720211
Hemoglobin crystals immersed in liquid oxygen reveal diffusion channelsQ47287993
Methemoglobinemia: a diagnosis not to be missedQ47696504
Anti-tumor mechanism of Artemisia annua based on bioinformaticsQ50108840
Uptake and translocation of metformin, ciprofloxacin and narasin in forage- and crop plants.Q50529369
Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.Q51803528
Metformin action: concentrations matter.Q52970022
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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell MitochondriaQ58035665
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Glycosylated haemoglobin and reticulocyte count in diabetesQ70337425
The abnormality of glucose transporter in the erythrocyte membrane of Chinese type 2 diabetic patientsQ73822214
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cellsQ89047120
Metformin Improves Diabetic Bone Health by Re-Balancing Catabolism and Nitrogen DisposalQ28551882
Measurement of metformin concentration in erythrocytes: clinical implicationsQ33186343
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisQ33597162
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Lactic acidosis induced by metformin: incidence, management and preventionQ33654578
Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis.Q33766770
Establishment of a database of metformin plasma concentrations and erythrocyte levels in normal and emergency situationsQ33845157
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.Q33919545
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy stateQ33968008
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cellsQ33971668
Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjectsQ34221188
Structure, function, and assembly of heme centers in mitochondrial respiratory complexesQ34272542
Respiration triggers heme transfer from cytochrome c peroxidase to catalase in yeast mitochondriaQ34709071
Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes StudyQ35841253
Foxo3 is required for the regulation of oxidative stress in erythropoiesisQ35916147
Cellular responses to the metal-binding properties of metformin.Q35976604
Catalase: a tetrameric enzyme with four tightly bound molecules of NADPH.Q36272030
Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinasesQ36559262
Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?Q36831560
Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes StudyQ36935521
Stationary phase in the yeast Saccharomyces cerevisiaeQ37059288
Accelerated autoxidation and heme loss due to instability of sickle hemoglobinQ37481142
The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissuesQ38065670
Exploring the role of metformin in anticancer treatments: a systematic review.Q38260036
Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013.Q38706627
Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.Q38809316
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.Q39491810
Hydrogen peroxide metabolism in yeastsQ39920292
P433issue2
P921main subjectmetforminQ19484
P304page(s)513-522
P577publication date2019-02-07
P1433published inG3Q5512701
P1476titleMetformin Affects Heme Function as a Possible Mechanism of Action
P478volume9