IGNITE4: Results of a Phase 3, Randomized, Multicenter, Prospective Trial of Eravacycline vs Meropenem in the Treatment of Complicated Intraabdominal Infections

scientific article published on 01 August 2019

IGNITE4: Results of a Phase 3, Randomized, Multicenter, Prospective Trial of Eravacycline vs Meropenem in the Treatment of Complicated Intraabdominal Infections is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/CID/CIY1029
P932PMC publication ID6735687
P698PubMed publication ID30561562

P50authorJoseph S SolomkinQ64029407
Janis GardovskisQ79309972
P2093author name stringDavid Evans
Philippe Montravers
Larry Tsai
Kenneth Lawrence
Angie Sway
P2860cites workSurveillance of tigecycline activity tested against clinical isolates from a global (North America, Europe, Latin America and Asia-Pacific) collection (2016).Q50148742
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Randomized, Double-Blind, Placebo-Controlled Studies of the Safety and Pharmacokinetics of Single and Multiple Ascending Doses of EravacyclineQ57789735
Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical TrialQ61727885
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Perforated and Gangrenous Appendicitis: An Analysis of Antibiotic FailuresQ72792662
Source control for surgical infectionsQ80175127
Intra-abdominal infectionsQ83467775
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Treatment options for carbapenem-resistant and extensively drug-resistant Acinetobacter baumannii infectionsQ26991886
The global spread of healthcare-associated multidrug-resistant bacteria: a perspective from AsiaQ27001437
Carbapenems versus alternative antibiotics for the treatment of bacteraemia due to Enterobacteriaceae producing extended-spectrum β-lactamases: a systematic review and meta-analysisQ27002495
Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of AmericaQ28268745
The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace.Q30234957
The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal InfectionQ30275008
The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial dataQ30998307
Phase 2, randomized, double-blind study of the efficacy and safety of two dose regimens of eravacycline versus ertapenem for adult community-acquired complicated intra-abdominal infectionsQ33622765
A randomized trial of tigecycline versus ampicillin-sulbactam or amoxicillin-clavulanate for the treatment of complicated skin and skin structure infectionsQ34474973
Assessing the Efficacy and Safety of Eravacycline vs Ertapenem in Complicated Intra-abdominal Infections in the Investigating Gram-Negative Infections Treated With Eravacycline (IGNITE 1) Trial: A Randomized Clinical TrialQ34544823
Ceftolozane/Tazobactam Plus Metronidazole for Complicated Intra-abdominal Infections in an Era of Multidrug Resistance: Results From a Randomized, Double-Blind, Phase 3 Trial (ASPECT-cIAI).Q35545954
Klebsiella pneumoniae bloodstream infection: epidemiology and impact of inappropriate empirical therapyQ36150730
Efficacy and Safety of Ceftazidime-Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-abdominal Infection: Results From a Randomized, Controlled, Double-Blind, Phase 3 ProgramQ36915096
Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysisQ36937529
Antimicrobial resistance: impact on clinical and economic outcomes and the need for new antimicrobials.Q38286351
Multidrug-Resistant Enterococcal Infections: New Compounds, Novel Antimicrobial Therapies?Q38756408
rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines.Q38849606
Antimicrobial resistance and resistance mechanisms of Enterobacteriaceae in ICU and non-ICU wards in Europe and North America: SMART 2011-2013.Q39164904
In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii.Q40135682
Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: results from the Study for Monitoring Antimicrobial ResistaQ40517201
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In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline.Q40633420
A randomized phase 2 study comparing two doses of delafloxacin with tigecycline in adults with complicated skin and skin-structure infectionsQ41634906
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.Q41879631
Phase 3 study comparing tigecycline and ertapenem in patients with diabetic foot infections with and without osteomyelitisQ42232433
A multicentre, open-label, randomized comparative study of tigecycline versus ceftriaxone sodium plus metronidazole for the treatment of hospitalized subjects with complicated intra-abdominal infectionsQ42952452
Antimicrobial activity among gram-positive and gram-negative organisms collected from the Asia-Pacific region as part of the Tigecycline Evaluation and Surveillance Trial: Comparison of 2015 results with previous yearsQ46300256
From "An Enzyme Able to Destroy Penicillin" to Carbapenemases: 70 Years of Beta-lactamase MisbehaviourQ47951222
In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.Q50023017
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjectmeropenemQ421670
multicenter clinical trialQ6934595
phase III clinical trialQ42824827
P304page(s)921-929
P577publication date2019-08-01
P1433published inClinical Infectious DiseasesQ5133764
P1476titleIGNITE4: Results of a Phase 3, Randomized, Multicenter, Prospective Trial of Eravacycline vs Meropenem in the Treatment of Complicated Intraabdominal Infections
P478volume69

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cites work (P2860)
Q90171597Antibiotics in the clinical pipeline in October 2019
Q89598600Carbapenem-Sparing Strategies for ESBL Producers: When and How
Q64244026Eravacycline: A Review in Complicated Intra-Abdominal Infections
Q92070193FDA approved antibacterial drugs: 2018-2019
Q92953652In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of Mycobacterium abscessus
Q64911007The "Old" and the "New" Antibiotics for MDR Gram-Negative Pathogens: For Whom, When, and How.
Q91742696The Continuing Threat of Methicillin-Resistant Staphylococcus aureus
Q92856050The Efficacy and Safety of Eravacycline in the Treatment of Complicated Intra-Abdominal Infections: A Systemic Review and Meta-Analysis of Randomized Controlled Trials
Q99708918Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance
Q64108242Treatment of Infections Due to MDR Gram-Negative Bacteria

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