Target-Mediated Drug Disposition Pharmacokinetic/Pharmacodynamic Model-Informed Dose Selection for the First-in-Human Study of AVB-S6-500

scientific article published on 25 October 2019

Target-Mediated Drug Disposition Pharmacokinetic/Pharmacodynamic Model-Informed Dose Selection for the First-in-Human Study of AVB-S6-500 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CTS.12706
P932PMC publication ID6951457
P698PubMed publication ID31599479

P2093author name stringAmato Giaccia
Gail McIntyre
Michael Dodds
Aaron Moss
David Prohaska
Laura Bonifacio
Ray Tabibiazar
P2860cites workAntibody therapy of cancerQ28262538
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Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Q34217927
A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study designQ34223916
Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblastsQ34380670
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axisQ34439798
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinaseQ36556713
Scaling pharmacodynamics from in vitro and preclinical animal studies to humansQ37055123
Reprogramming the immunological microenvironment through radiation and targeting Axl.Q37541688
Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapiesQ37545045
Molecular insights of Gas6/TAM in cancer development and therapy.Q37745358
Population Pharmacokinetics of Therapeutic Monoclonal AntibodiesQ37785528
Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine KinaseQ38746437
Pharmacologic target-mediated drug dispositionQ40631377
GAS6 mediates adhesion of cells expressing the receptor tyrosine kinase Axl.Q41091650
General pharmacokinetic model for drugs exhibiting target-mediated drug dispositionQ43985366
Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction.Q51612613
P433issue1
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)204-211
P577publication date2019-10-25
P1433published inClinical and Translational ScienceQ5133809
P1476titleTarget-Mediated Drug Disposition Pharmacokinetic/Pharmacodynamic Model-Informed Dose Selection for the First-in-Human Study of AVB-S6-500
P478volume13

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