GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats

scientific article published on 24 March 2020

GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41598-020-62192-8
P932PMC publication ID7093419
P698PubMed publication ID32210319

P50authorHong JiangQ87811127
P2093author name stringHao Wang
Rong Hu
Yu Sun
Chen Huang
Jia Yan
Yelin Chen
Chunzhu Li
Dewei Tang
Chaoying Fu
Jidong Zhu
P2860cites workKetamine activates cell cycle signaling and apoptosis in the neonatal rat brain.Q43085996
The opioid receptor binding of dezocine, morphine, fentanyl, butorphanol and nalbuphineQ44337930
The Role of Science in Addressing the Opioid CrisisQ44346078
Nalmefene: safety and kinetics after single and multiple oral doses of a new opioid antagonistQ44350017
The fentanyl storyQ46163348
Nalmefene reverses carfentanil-induced loss of righting reflex and respiratory depression in ratsQ47863006
Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficitsQ48569969
Maximum tolerated dose of nalmefene in patients receiving epidural fentanyl and dilute bupivacaine for postoperative analgesia.Q51368362
Comparison of alfentanil, fentanyl and sufentanil for total intravenous anaesthesia with propofol in patients undergoing coronary artery bypass surgery.Q51373415
Sevoflurane induces neurotoxicity in the developing rat hippocampus by upregulating connexin 43 via the JNK/c-Jun/AP-1 pathwayQ58123276
Safety and Efficacy of Ketamine Versus Ketamine-Fentanyl-Dexmedetomidine Combination for Anesthesia and Analgesia in RatsQ64245398
Neurosteroids and glutamate toxicity in fibroblasts expressing human NMDA receptorsQ73581332
KetamineQ81443501
Ketamine-induced hypnosis and neuroplasticity in mice is associated with disrupted p-MEK/p-ERK sequential activation and sustained upregulation of survival p-FADD in brain cortex: Involvement of GABAA receptorQ90024191
Flumazenil but not bicuculline counteract the impairing effects of anesthetic ketamine on recognition memory in rats. Evidence for a functional interaction between the GABAA-benzodiazepine receptor and ketamine?Q90825276
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial ActivationQ91240593
17β-Estradiol Treatment Attenuates Neurogenesis Damage and Improves Behavior Performance After Ketamine Exposure in Neonatal RatsQ91531522
Metabotropic functions of the NMDA receptor and an evolving rationale for exploring NR2A-selective positive allosteric modulators for the treatment of autism spectrum disorderQ93341615
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit FunctionQ27704016
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based DesignQ27704191
The effects of increasing plasma concentrations of dexmedetomidine in humansQ28141747
Developmental and regional expression in the rat brain and functional properties of four NMDA receptorsQ28570615
Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP miceQ30585962
Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosingQ33987817
D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosisQ34006224
Clinical uses of alpha2 -adrenergic agonistsQ34068639
Allosteric binding sites on cell-surface receptors: novel targets for drug discoveryQ34139176
Anesthetics and ion channels: molecular models and sites of actionQ34192657
Recovery from ketamine-induced amnesia by blockade of GABA-A receptor in the medial prefrontal cortex of miceQ34516988
Diversity in NMDA receptor composition: many regulators, many consequencesQ36597018
Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathwayQ36711438
Intravenous vs intramuscular ketamine for pediatric procedural sedation by emergency medicine specialists: a reviewQ37780565
Dexmedetomidine sedation: uses in pediatric procedural sedation outside the operating roomQ37990758
A randomized, placebo-controlled study of a new sublingual formulation of fentanyl citrate (fentanyl ethypharm) for breakthrough pain in opioid-treated patients with cancerQ38436582
Efficacy of intraoperative dexmedetomidine compared with placebo for surgery in adults: a meta-analysis of published studiesQ38501031
Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacyQ39008536
Enhancing NMDA Receptor Function: Recent Progress on Allosteric ModulatorsQ39121207
Fatal Fentanyl: One Pill Can KillQ39670532
Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptorsQ41082995
In vivo studies identify 5 alpha-pregnan-3 alpha-ol-20-one as an active anesthetic agentQ41161435
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo ProfileQ41792375
Nalmefene: intravenous safety and kinetics of a new opioid antagonistQ42226511
Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood.Q42406039
P433issue1
P304page(s)5265
P577publication date2020-03-24
P1433published inScientific ReportsQ2261792
P1476titleGluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats
P478volume10

Search more.