Fc-apelin fusion protein attenuates lipopolysaccharide-induced liver injury in mice

scientific article published on 30 July 2018

Fc-apelin fusion protein attenuates lipopolysaccharide-induced liver injury in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-018-29491-7
P932PMC publication ID6065397
P698PubMed publication ID30061611

P2093author name stringHong Zhang
Feng Xu
Lin Shi
Weimin Wang
Da-Wei Gong
Rongze Yang
Yue Xi
Dalong Zhu
Robert A Brown
Huifen Zhou
P2860cites workIsolation and characterization of a novel endogenous peptide ligand for the human APJ receptorQ22004174
ELABELA: a hormone essential for heart development signals via the apelin receptorQ24311664
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11Q24336729
Toll-like receptor signallingQ24570126
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasisQ26852413
Markers of mouse macrophage development detected by monoclonal antibodiesQ28247978
Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complicationsQ28469007
The family of five: TIR-domain-containing adaptors in Toll-like receptor signallingQ29615457
Elabela-apelin receptor signaling pathway is functional in mammalian systemsQ30032663
Toddler: an embryonic signal that promotes cell movement via Apelin receptorsQ30584600
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicityQ34048452
Design and characterization of structured protein linkers with differing flexibilitiesQ34313196
Fighting the stranger-antioxidant protection against endotoxin toxicityQ34904541
Oxidative stress and gene expression in sepsisQ35049808
Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs ActivationQ35951891
Aspartate alleviates liver injury and regulates mRNA expressions of TLR4 and NOD signaling-related genes in weaned pigs after lipopolysaccharide challenge.Q50667849
Hepatic and cardiac beneficial effects of a long-acting Fc-apelin fusion protein in diet-induced obese mice.Q51244457
Apelin Regulates Nuclear Factor-κB's Involvement in the Inflammatory Response of Pancreatitis.Q51326489
Superoxide anion generation in the liver during the early stage of endotoxemia in rats.Q54710671
Critical evaluation of the use of hydroethidine as a measure of superoxide anion radicalQ77583722
Hypoxia and proinflammatory factors upregulate apelin receptor expression in human stellate cells and hepatocytesQ83750090
Circulating apoptotic and necrotic cell death markers in patients with acute liver injuryQ84538111
Apelin antagonizes myocardial impairment in sepsisQ84540210
Effects of Apelin on RAW264.7 cells under both normal and hypoxic conditionsQ87288064
Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategiesQ36870030
Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouseQ36981852
Pancreatitis activates pancreatic apelin-APJ axis in miceQ37051499
NF-kappaB signaling, liver disease and hepatoprotective agentsQ37302741
Apelin attenuates oxidative stress in human adipocytes.Q37563582
Reactive oxygen and mechanisms of inflammatory liver injury: Present conceptsQ37825662
Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review).Q38795465
Apelin-13 in blood pressure regulation and cardiovascular disease.Q38852675
Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation.Q38989309
In vitro and in vivo experimental hepatotoxic models in liver research: applications to the assessment of potential hepatoprotective drugsQ39050044
Targeting hepatic macrophages to treat liver diseasesQ39166232
F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and SpleenQ39271611
Apelin attenuates postburn sepsis via a phosphatidylinositol 3-kinase/protein kinase B dependent mechanism: A randomized animal studyQ41113635
Protective effect of apelin on cultured rat bone marrow mesenchymal stem cells against apoptosisQ42557243
Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophyQ43096140
Lipopolysaccharide-induced inflammatory liver injury in mice.Q45874575
Vascular effects of apelin in vivo in man.Q46389030
Overexpression of granulocyte-macrophage colony-stimulating factor in mouse liver enhances the susceptibility of lipopolysaccharide leading to massive apoptosis of hepatocytesQ46702714
ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic ShockQ47304688
Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial DysfunctionQ47701561
From the Cover: Lung-Specific Overexpression of Constitutively Active IKK2 Induces Pulmonary and Systemic Inflammations but Not Hypothalamic Inflammation and Glucose IntoleranceQ50074745
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P2507corrigendum / erratumAuthor Correction: Fc-apelin fusion protein attenuates lipopolysaccharide-induced liver injury in miceQ59802321
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectlipopolysaccharideQ421804
P304page(s)11428
P577publication date2018-07-30
P1433published inScientific ReportsQ2261792
P1476titleFc-apelin fusion protein attenuates lipopolysaccharide-induced liver injury in mice
P478volume8

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Q101051274β-Arrestin2 deficiency attenuates oxidative stress in mouse hepatic fibrosis through modulation of NOX4cites workP2860

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