PI3Kγ (Phosphoinositide 3-Kinase-γ) Inhibition Attenuates Tissue-Type Plasminogen Activator-Induced Brain Hemorrhage and Improves Microvascular Patency After Embolic Stroke

scientific article published on 01 January 2019

PI3Kγ (Phosphoinositide 3-Kinase-γ) Inhibition Attenuates Tissue-Type Plasminogen Activator-Induced Brain Hemorrhage and Improves Microvascular Patency After Embolic Stroke is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/HYPERTENSIONAHA.118.12001
P932PMC publication ID6309896
P698PubMed publication ID30571560

P2093author name stringRong Jin
Guohong Li
Min Wang
Jarvis Li
Adam Y Xiao
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The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.Q54684259
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Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart AssociationQ30238784
Cerebral microvascular obstruction by fibrin is associated with upregulation of PAI-1 acutely after onset of focal embolic ischemia in ratsQ30826562
Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trialsQ31048053
MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke.Q33322709
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Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental strokeQ35202539
Platelet–leukocyte interactions link inflammatory and thromboembolic events in ischemic strokeQ35633718
Platelet PI3Kγ Contributes to Carotid Intima-Media Thickening under Severely Reduced Flow ConditionsQ35656802
Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain InjuryQ35876779
Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic strokeQ35905986
The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetesQ35976619
Embolic middle cerebral artery occlusion (MCAO) for ischemic stroke with homologous blood clots in ratsQ36788142
Hypertension and experimental stroke therapiesQ37073438
NF‐κB and innate immunity in ischemic strokeQ37252167
Microvascular protection is essential for successful neuroprotection in stroke.Q38050820
Animal models of ischemic stroke and their application in clinical researchQ38546471
Thromboinflammation in Stroke Brain DamageQ38703081
Atorvastatin extends the therapeutic window for tPA to 6 h after the onset of embolic stroke in ratsQ39791602
Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke.Q40458860
Seizures and recovery from experimental brain damageQ41405943
Extension of the thrombolytic time window with minocycline in experimental stroke.Q41812595
Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusionQ42509508
Resistance to thromboembolism in PI3Kgamma-deficient mice.Q43711871
Postischemic (6-Hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemiaQ43820256
Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in ratsQ43901758
PI3K-γ inhibition ameliorates acute lung injury through regulation of IκBα/NF-κB pathway and innate immune responsesQ44300358
Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboonsQ45007330
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupusQ46674138
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.Q46674143
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processesQ46758917
Platelet CD40 Mediates Leukocyte Recruitment and Neointima Formation after Arterial Denudation Injury in Atherosclerosis-Prone MiceQ47645034
P433issue1
P921main subjectplasminogenQ107129060
embolic strokeQ107538662
P304page(s)206-216
P577publication date2019-01-01
P1433published inHypertensionQ5958695
P1476titlePI3Kγ (Phosphoinositide 3-Kinase-γ) Inhibition Attenuates Tissue-Type Plasminogen Activator-Induced Brain Hemorrhage and Improves Microvascular Patency After Embolic Stroke
P478volume73