Cathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against Pseudomonas aeruginosa

scientific article published on 19 September 2019

Cathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against Pseudomonas aeruginosa is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FMICB.2019.02190
P932PMC publication ID6761703
P698PubMed publication ID31608030

P50authorImran MohammedQ51214011
P2093author name stringLeonardo Mastropasqua
Mario Nubile
Harminder S Dua
Dalia G Said
P2860cites workDecoding the Functional Roles of Cationic Side Chains of the Major Antimicrobial Region of Human Cathelicidin LL-37Q27675567
High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragmentsQ27692605
Optimizing the Clinical Use of VancomycinQ28069334
Responses of Pseudomonas aeruginosa to antimicrobialsQ28305587
Novel engineered cationic antimicrobial peptides display broad-spectrum activity against Francisella tularensis, Yersinia pestis and Burkholderia pseudomallei.Q30382544
Cytotoxic clinical isolates of Pseudomonas aeruginosa identified during the Steroids for Corneal Ulcers Trial show elevated resistance to fluoroquinolonesQ33559958
Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivoQ33700171
Antibiotic resistance-the need for global solutionsQ34386251
Cathelicidin-deficient (Cnlp -/- ) mice show increased susceptibility to Pseudomonas aeruginosa keratitisQ34522531
Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or ChromosomesQ34552966
FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells.Q34735130
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Bacterial infections of the cornea (Pseudomonas aeruginosa).Q36722835
Cationic host defence peptides: innate immune regulatory peptides as a novel approach for treating infections.Q36740138
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Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitisQ37228376
Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins.Q37810333
Multidrug-Resistant Pseudomonas aeruginosa Keratitis: Risk Factors, Clinical Characteristics, and OutcomesQ38550094
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Human antimicrobial peptides in ocular surface defense.Q39355040
Increased susceptibility of Pseudomonas aeruginosa to ciprofloxacin in the presence of vancomycinQ39882590
Outcomes of Infectious versus Sterile Perforated Corneal Ulcers after Therapeutic Penetrating Keratoplasty in the United StatesQ39924784
Titanium surfaces immobilized with the major antimicrobial fragment FK-16 of human cathelicidin LL-37 are potent against multiple antibiotic-resistant bacteriaQ40148057
The Naturally Occurring Host Defense Peptide, LL-37, and Its Truncated Mimetics KE-18 and KR-12 Have Selected Biocidal and Antibiofilm Activities Against Candida albicans, Staphylococcus aureus, and Escherichia coli In vitro.Q40251230
Glycopeptide Antibiotic To Overcome the Intrinsic Resistance of Gram-Negative Bacteria.Q40541296
Intracellular activity of a membrane-active glycopeptide antibiotic against meticillin-resistant Staphylococcus aureus infectionQ40606977
Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of actionQ41456132
Update on the Management of Infectious KeratitisQ41931288
Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Pseudomonas aeruginosa Murine Cutaneous Infection ModelQ41986754
Structural location determines functional roles of the basic amino acids of KR-12, the smallest antimicrobial peptide from human cathelicidin LL-37.Q42053270
Profile of sight-threatening infectious keratitis: a prospective studyQ43671905
Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolonesQ44328530
Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probesQ46375567
Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of Escherichia coli and Pseudomonas aeruginosa.Q50052264
LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activityQ50208808
Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications.Q52337071
Activity of antimicrobial peptides and conventional antibiotics against superantigen positive Staphylococcus aureus isolated from patients with atopic dermatitis.Q53700112
Rational design and synthesis of modified teixobactin analogues: in vitro antibacterial activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa.Q54217425
Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.Q54466322
Cathelicidin-Derived Antimicrobial Peptides Inhibit Zika Virus Through Direct Inactivation and Interferon Pathway.Q54558551
The spectrum of antimicrobial peptide expression at the ocular surface.Q54673989
Antimicrobial Peptides: Interaction With Model and Biological Membranes and Synergism With Chemical Antibiotics.Q55252918
Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens.Q55432018
Characterization of host responses during acute lung infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002Q57462992
Antimicrobial peptide LL-37 and its truncated forms, GI-20 and GF-17, exert spermicidal effects and microbicidal activity against Neisseria gonorrhoeaeQ57791643
Antimicrobial resistance and the role of vaccinesQ60301815
Reassessing the Host Defense Peptide LandscapeQ61799995
The ‘up–down’ sign of acute ocular surface drug toxicityQ61824876
Successful treatment of multidrug-resistant Pseudomonas aeruginosa meningitis with intravenous and intrathecal colistinQ81428554
Multifunctional roles of human cathelicidin (LL-37) at the ocular surfaceQ83839600
Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumanniiQ90458028
Antibiotic Resistance Rates by Geographic Region Among Ocular Pathogens Collected During the ARMOR Surveillance StudyQ90864213
Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal InfectionsQ93015814
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectPseudomonas aeruginosaQ31856
vancomycinQ424027
P304page(s)2190
P577publication date2019-09-19
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleCathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against Pseudomonas aeruginosa
P478volume10

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cites work (P2860)
Q104795267Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance
Q96303599Strategies in Translating the Therapeutic Potentials of Host Defense Peptides

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