Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

scientific article published on 26 July 2018

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1590/0074-02760180162
P932PMC publication ID6060400
P698PubMed publication ID30066751

P50authorSergio SchenkmanQ30348027
Silvane Maria Fonseca MurtaQ66829448
Alvaro José RomanhaQ107168961
Douglas de Souza MoreiraQ118901125
P2093author name stringAna Paula Duarte
Fabiano Sviatopolk Mirsky Pais
Rosiane Aparecida da Silva-Pereira
P2860cites workInduced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytesQ24562720
Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modificationQ24650882
New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0Q27860476
eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequencesQ33878081
Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma.Q34095605
Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing ProteinsQ35925923
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxificationQ37202974
Targeting Trypanothione Metabolism in Trypanosomatid Human ParasitesQ37782110
Expression of eukaryotic translation initiation factor 5A-2 (eIF5A-2) associated with poor survival in gastric cancerQ38843125
eIF5A Functions Globally in Translation Elongation and Termination.Q38845545
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single populationQ39242262
Molecular characterization of lipoamide dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazoleQ39446821
Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell lineQ39879899
Phosphoproteomic analysis of wild-type and antimony-resistant Leishmania braziliensis lines by 2D-DIGE technologyQ40955917
Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazoleQ41754510
Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transitionQ41789947
Experimental and Clinical Treatment of Chagas Disease: A Review.Q41989175
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cellsQ42800718
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermineQ42829475
Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells.Q45924848
Aldo-keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruziQ46310403
The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide.Q46350947
Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi.Q46916018
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazoleQ47115930
MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization.Q47664445
Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis.Q49217051
In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole.Q54144383
Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes.Q54197776
Expression of exogenous genes in Trypanosoma cruzi: improving vectors and electroporation protocolsQ79318087
P433issue9
P921main subjectTrypanosoma cruziQ150162
benznidazoleQ425300
P304page(s)e180162
P577publication date2018-07-26
P1433published inMemórias do Instituto Oswaldo CruzQ15760238
P1476titleOverexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations
P478volume113

Search more.