Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer

scientific article published on 14 October 2019

Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.15252/EMMM.201910515
P932PMC publication ID6835203
P698PubMed publication ID31609088

P50authorChao XingQ41503549
Wenting DuQ61475916
Huocong HuangQ64148600
Rolf BrekkenQ89067063
Yuqing ZhangQ90687453
P2093author name stringEugene J Koay
Steven Wright
Kyla E Driscoll
Adwait Amod Sathe
Zhaoning Wang
Abdel Nasser Hosein
Noah Sorrelle
Jason Toombs
Mohamed Medhat Zaid
Moriah Hagopian
Valerie Gallegos
P2860cites workThe basics of epithelial-mesenchymal transitionQ24652992
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STATs in cancer inflammation and immunity: a leading role for STAT3Q29547203
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFQ29615685
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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1Q29616726
TGF-beta-induced epithelial to mesenchymal transitionQ29619820
Non-Smad pathways in TGF-beta signalingQ29620040
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinomaQ33896442
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survivalQ34269713
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expressionQ35127700
Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.Q35740663
Whole genomes redefine the mutational landscape of pancreatic cancerQ35911034
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The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemiaQ36772346
Basics of TGF-beta and pancreatic cancerQ36953049
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.Q37683769
Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts.Q38325637
Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasisQ38971921
LIF mediates proinvasive activation of stromal fibroblasts in cancerQ38992217
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancerQ39076225
Novel TGF-β inhibitors ready for prime time in onco-immunologyQ39135708
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United StatesQ39190004
Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1.Q39411956
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Q39540918
Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cellsQ39741489
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunityQ40351340
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillanceQ40351779
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathwayQ40788629
TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progressionQ41892306
TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate TumorigenesisQ42775736
Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survivalQ44680447
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasisQ50001731
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.Q50001757
Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor.Q50173304
IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling.Q51709053
Contextual determinants of TGFβ action in development, immunity and cancer.Q52593116
Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillanceQ57174100
IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinomaQ58113127
Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic ProgressionQ58548008
Interleukin-6 and Type-I Collagen Production by Systemic Sclerosis Fibroblasts Are Differentially Regulated by Interleukin-17A in the Presence of Transforming Growth Factor-Beta 1Q58785737
Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic CancerQ60594558
Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsivenessQ69880388
Xenotransplantation of human lymphoid malignancies is optimized in mice with multiple immunologic defectsQ77653649
Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded TissuesQ90226839
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and MetastasisQ91264732
Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolutionQ92118472
Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic CancerQ92470740
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated FibroblastsQ92732735
P4510describes a project that usesedgeRQ113334690
P433issue11
P921main subjectpancreatic cancerQ212961
P304page(s)e10515
P577publication date2019-10-14
P1433published inEMBO Molecular MedicineQ15817279
P1476titleTargeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
P478volume11

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cites work (P2860)
Q94562389Pancreatic cancer stroma: an update on therapeutic targeting strategies
Q97867213TGFβ biology in cancer progression and immunotherapy
Q104795035Targeting TGFβ signal transduction for cancer therapy

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