A multiparametric organ toxicity predictor for drug discovery

scientific article published on 29 October 2019

A multiparametric organ toxicity predictor for drug discovery is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/15376516.2019.1681044
P932PMC publication ID7383222
P698PubMed publication ID31618094

P50authorFrank J. GonzalezQ86888845
Himanshu A PandyaQ90743877
Rakesh M RawalQ56487623
Sivakumar Prasanth KumarQ56811304
Chirag N PatelQ61163094
P2093author name stringDaxesh P Patel
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological ResearchQ24530127
Use of QSARs in international decision-making frameworks to predict health effects of chemical substancesQ24815781
The Tox21 robotic platform for the assessment of environmental chemicals--from vision to realityQ26998816
Network medicine: a network-based approach to human diseaseQ29547462
Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionQ29616762
Prediction of CNS activity of compound libraries using substructure analysisQ30883319
Chemical genomics profiling of environmental chemical modulation of human nuclear receptorsQ33890181
Cardiotoxicity of chemotherapeutic agents: incidence, treatment and preventionQ33903066
An active role for machine learning in drug developmentQ33935909
The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platformQ34367618
The ToxCast program for prioritizing toxicity testing of environmental chemicalsQ34564990
Quantitative structure-activity relationships for predicting mutagenicity and carcinogenicityQ35201873
Early prediction of drug metabolism and toxicity: systems biology approach and modelingQ35666147
Role of Pharmacovigilance in India: An overviewQ36077051
In silico toxicology models and databases as FDA Critical Path Initiative toolkitsQ36405302
Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterizationQ36648761
From the analyst's couch. Trends in development cyclesQ74468330
Harmonization in the regulation of pharmaceutical research and human rights: the need to think globallyQ74652368
A modification of the nitroprusside method of analysis for glutathioneQ75670646
A method for the rapid determination of alkaline phosphates with five cubic millimeters of serumQ82134081
Systems toxicologyQ84075193
Spectrophotometric Assay for Superoxide Dismutase Based on the Reduction of Highly Water-soluble Tetrazolium Salts by Xanthine-Xanthine OxidaseQ87852768
Perspectives on In Vitro to In Vivo ExtrapolationsQ92345127
Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodiesQ36774623
Improving the human hazard characterization of chemicals: a Tox21 updateQ36984065
Computational toxicology--a state of the science mini reviewQ37027100
Computational toxicology in drug developmentQ37135902
Alzheimer's disease clinical and research update for health care practitionersQ37180713
Toxicology. Transforming environmental health protectionQ37185407
Computational models for drug inhibition of the human apical sodium-dependent bile acid transporterQ37376544
Alternative strategies for toxicity testing of species-specific biopharmaceuticalsQ37527451
Neuropsychiatric symptoms in Parkinson's diseaseQ37600783
Computational toxicology--a tool for early safety evaluationQ37616328
A generic operational strategy to qualify translational safety biomarkersQ37875384
Biomarker Qualification: Toward a Multiple Stakeholder Framework for Biomarker Development, Regulatory Acceptance, and UtilizationQ38418590
Nonclinical safety testing of biopharmaceuticals--Addressing current challenges of these novel and emerging therapies.Q38980247
Prediction of blood-brain partitioning using Monte Carlo simulations of molecules in waterQ39122338
The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay is a fast and reliable method for colorimetric determination of fungal cell densitiesQ39483161
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidaseQ39513011
ELISA: Enzyme-Linked Immunosorbent AssayQ40197912
The sensitivity and specificity of the MTS tetrazolium assay for detecting the in vitro cytotoxicity of 20 chemicals using human cell linesQ41063192
Natural products in drug discovery and developmentQ41334729
Network medicine in disease analysis and therapeuticsQ41890269
Comparisons of two in vitro cytotoxicity assays-The neutral red (NR) and tetrazolium MTT testsQ41912439
Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles by liver microsomes: interspecies differences and structure-metabolism relationshipsQ44135058
The 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay as rapid colorimetric method for determination of antibiotic susceptibility of clinical Mycobacterium tuberculosis isolates in liquid medium.Q44543084
The target landscape of clinical kinase drugsQ47345032
ADVERPred-Web Service for Prediction of Adverse Effects of Drugs.Q47366719
A toxicity evaluation and predictive system based on neural networks and waveletsQ48275343
Self-organizing neural projectionsQ48496933
Modeling blood-brain barrier partitioning using the electrotopological stateQ48567415
Use of toxicological information in drug designQ48623791
In silico prediction of blood brain barrier permeability: an Artificial Neural Network model.Q48680746
Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies.Q52654942
The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans.Q53135035
Distribution of adenosinetriphosphatase activity in ram and bull spermatozoa.Q53745931
Informatics and Computational Methods in Natural Product Drug Discovery: A Review and PerspectivesQ64078667
Improved determination of total serum lipids by the sulfo-phospho-vanillin reactionQ70403772
A modified spectrophotometric assay of superoxide dismutaseQ70646496
Purification and Subunit Structure of Glutathione Reductase from Bakers' YeastQ72023525
A new method for the direct determination of serum cholesterolQ73102142
A simple method for assaying adenosine triphosphate and adenosine diphosphate in mixturesQ74025206
P433issue3
P921main subjectdrug discoveryQ1418791
P304page(s)159-166
P577publication date2019-10-29
P1433published inToxicology Mechanisms and MethodsQ7830408
P1476titleA multiparametric organ toxicity predictor for drug discovery
P478volume30

Search more.