DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice

scientific article published on 10 October 2019

DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41420-019-0220-4
P932PMC publication ID6787076
P698PubMed publication ID31632741

P50authorRichard T. LibbyQ42111552
Olivia J MarolaQ90839050
P2093author name stringStephanie B Syc-Mazurek
P2860cites workCHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cellsQ24301679
hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondriaQ24306768
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stressQ24339500
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosageQ24811545
Axon injury induced endoplasmic reticulum stress and neurodegenerationQ28068989
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonismQ28579022
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosisQ28586997
Investigating the effect of ciliary body photodynamic therapy in a glaucoma mouse modelQ33244631
Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucomaQ33249314
Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetricQ33259237
Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1Q33289814
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma modelQ33368412
Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crushQ33488710
DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injuryQ33906032
Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling dataQ34001885
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucomaQ34755301
Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cellsQ35176367
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.Q35187142
Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signalingQ36022252
The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J miceQ36114184
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucomaQ36639100
Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.Q36932922
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasisQ37056644
Prevention of vision loss protects against age-related impairment in learning and memory performance in DBA/2J miceQ37180041
Involvement of the Bcl2 gene family in the signaling and control of retinal ganglion cell deathQ37301634
Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucomaQ37726620
Endoplasmic reticulum stress and C/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytesQ38319254
RNA binding protein with multiple splicing: a new marker for retinal ganglion cellsQ38657681
BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cellsQ39073674
Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegenerationQ39132026
Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.Q41087457
Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss.Q41335521
JUN is important for ocular hypertension-induced retinal ganglion cell degeneration.Q41335577
JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell deathQ42030670
Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injuryQ42074646
BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cellsQ42183839
Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injuryQ42284692
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J miceQ42665432
Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J miceQ42914157
JUN regulates early transcriptional responses to axonal injury in retinal ganglion cellsQ43107105
Retinal ganglion cell death induced by endoplasmic reticulum stress in a chronic glaucoma modelQ43255779
Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse modelQ44154809
Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axonsQ44321301
A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucomaQ48420128
Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.Q54121945
AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer FormationQ58774011
Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucomaQ71722798
Bax-dependent and independent pathways of retinal ganglion cell death induced by different damaging stimuliQ74127088
Involvement of endoplasmic reticulum stress in optic nerve degeneration after chronic high intraocular pressure in DBA/2J miceQ85896953
P4510describes a project that usesImageJQ1659584
P921main subjectretinal ganglion cellQ927337
P304page(s)140
P577publication date2019-10-10
P1433published inCell Death DiscoveryQ27726740
P1476titleDDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice
P478volume5

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cites work (P2860)
Q92068835Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage
Q100295942Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation

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