Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases

scientific article published on 18 November 2019

Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-019-2119-7
P932PMC publication ID6861224
P698PubMed publication ID31740667

P50authorYuh-Ru Julie LeeQ89394570
P2093author name stringSoichiro Yamada
Su Hao Lo
Chun-Lung Chiu
Zong-Ye Wu
Ethan Lo
P2860cites workThe phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1Q24338316
Genome-wide association study identifies five loci associated with lung functionQ24629653
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activitiesQ24684712
Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensinQ28216811
Tensin1 positively regulates RhoA activity through its interaction with DLC1Q28392191
Progressive kidney degeneration in mice lacking tensinQ28513644
Regulation of tensin-promoted cell migration by its focal adhesion binding and Src homology domain 2.Q30757298
Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cellsQ33984904
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.Q33985882
From cells to organs: building polarized tissue.Q34066373
Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1.Q34103668
The cell biology of polycystic kidney diseaseQ34149966
TensinQ34273615
Presence of an SH2 domain in the actin-binding protein tensinQ34579865
Distinct roles of cadherin-6 and E-cadherin in tubulogenesis and lumen formationQ35041609
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung functionQ36099476
Interactions of tensin with actin and identification of its three distinct actin-binding domainsQ36234270
Genetic association analyses highlight biological pathways underlying mitral valve prolapseQ36638702
Cystic disease of the kidney.Q37014727
Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD.Q37049561
Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.Q37119771
Mouse models of polycystic kidney diseaseQ37383079
Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer.Q37589161
Molecular regulation of lumen morphogenesis.Q37837188
Molecular mechanisms of de novo lumen formationQ38245882
AMPK negatively regulates tensin-dependent integrin activity.Q38712389
ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture.Q38734544
Tensins are versatile regulators of Rho GTPase signalling and cell adhesionQ38982601
Tensins: Bridging AMP-Activated Protein Kinase with Integrin ActivationQ39429231
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneysQ44445058
TensinsQ44711935
Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activityQ48120748
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.Q50972840
Extracellular cleavage of E-cadherin promotes epithelial cell extrusion.Q53044996
Localization of a 215-kDa tyrosine-phosphorylated protein that cross-reacts with tensin antibodiesQ67545269
Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney diseaseQ83206006
Molecular mechanisms of polycystic kidney diseaseQ84872899
HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney diseaseQ91263324
P4510describes a project that usesImageJQ1659584
P433issue12
P921main subjectkidney diseaseQ1054718
P304page(s)871
P577publication date2019-11-18
P1433published inCell Death and DiseaseQ2197222
P1476titleHyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases
P478volume10

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