STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease

scientific article published on 19 November 2019

STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41374-019-0342-6
P698PubMed publication ID31745210

P2093author name stringFeng Liu
Xiaoxiao Wang
Lai Wei
Chaodong Wu
Rui Huang
Xiaohe Li
Huiying Rao
Ran Fei
Jingmin Zhao
Aileen Wee
P2860cites workSTING is an endoplasmic reticulum adaptor that facilitates innate immune signallingQ24336398
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activationQ28256216
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysisQ30238749
Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease.Q30375131
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.Q30596736
Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humansQ34159110
Current and upcoming pharmacotherapy for non-alcoholic fatty liver diseaseQ34540703
Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infectionQ35358973
Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and ChildrenQ36791363
Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategiesQ36870030
STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.Q37236401
STING-dependent cytosolic DNA sensing pathwaysQ38169005
Macrophage heterogeneity in liver injury and fibrosisQ38177568
The immunophenotype of antigen presenting cells of the mononuclear phagocyte system in normal human liver--a systematic reviewQ38260237
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.Q38680300
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced ObesityQ38711931
Positive feedback regulation of type I interferon by the interferon-stimulated gene STING.Q38921904
The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications.Q39099711
Targeting hepatic macrophages to treat liver diseasesQ39166232
Liver macrophages in tissue homeostasis and diseaseQ39187324
The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver diseaseQ39311652
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infectionQ40696672
Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblastsQ40852538
Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesisQ42111412
Global burden of NAFLD and NASH: trends, predictions, risk factors and preventionQ45067817
Therapeutic Inhibition of Inflammatory Monocyte Recruitment Reduces Steatohepatitis and Liver FibrosisQ45872331
Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylationQ47281872
cGAS-mediated autophagy protects the liver from ischemia/reperfusion injury independent of STING.Q49986890
Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease.Q50139495
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.Q50528458
Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis.Q51062671
Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.Q51346281
Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury.Q51702513
STING dependent sensing - Does HIV actually care?Q52352448
The macrophage activation marker sCD163 is associated with morphological disease stages in patients with non-alcoholic fatty liver disease.Q52873745
CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo.Q53543419
Circulating CD14(+) CD16(+) monocyte levels predict tissue invasive character of cholangiocarcinoma.Q54419476
Modeling NAFLD Disease Burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030Q56379571
Mechanisms of NAFLD development and therapeutic strategies.Q59443140
Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failureQ60713404
Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosisQ62735118
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver diseaseQ89235898
STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitisQ90609055
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in MiceQ91433764
P433issue4
P921main subjectmetabolic dysfunction–associated steatotic liver diseaseQ1546498
fatty liver diseaseQ6058862
bites and stingsQ54911704
P304page(s)542-552
P577publication date2019-11-19
P1433published inLaboratory InvestigationQ6467260
P1476titleSTING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease
P478volume100

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