| P50 | author | John Q. Trojanowski | Q6253636 |
| P2093 | author name string | Virginia M-Y Lee | |
| | Richard J Karpowicz | |
| P2860 | cites work | Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease | Q24321355 |
| | TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function | Q24338758 |
| | α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation | Q24605589 |
| | Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro | Q24629968 |
| | Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds | Q24630644 |
| | A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease | Q24633417 |
| | alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies | Q24653247 |
| | Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2 | Q26269886 |
| | Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism | Q26782028 |
| | Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis | Q27323098 |
| | Mutation in the alpha-synuclein gene identified in families with Parkinson's disease | Q27860459 |
| | alpha-Synuclein locus triplication causes Parkinson's disease | Q27860533 |
| | Alpha-synuclein in Lewy bodies | Q27860680 |
| | Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase | Q28116395 |
| | ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein | Q28118666 |
| | Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases | Q28119192 |
| | Staging of brain pathology related to sporadic Parkinson's disease | Q28131702 |
| | Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease | Q28275257 |
| | Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease | Q28292932 |
| | Distinct α-synuclein strains differentially promote tau inclusions in neurons | Q28293967 |
| | Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation | Q29615640 |
| | Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes | Q29617606 |
| | Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice | Q29620597 |
| | Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration | Q30373366 |
| | Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes | Q30607522 |
| | Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis | Q31028422 |
| | Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data | Q33226682 |
| | An essay on the shaking palsy. 1817. | Q33958859 |
| | The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system | Q34318718 |
| | Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity | Q34636872 |
| | Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. | Q34901494 |
| | Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). | Q35045422 |
| | Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism | Q35151971 |
| | Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation | Q35152964 |
| | Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death | Q35484581 |
| | Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration | Q35542169 |
| | Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation | Q35813688 |
| | Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice | Q35946149 |
| | Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells | Q35996987 |
| | Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates | Q36246469 |
| | Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy | Q36341144 |
| | Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport | Q36374952 |
| | Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal | Q36455215 |
| | Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1 | Q36680329 |
| | Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization | Q36744478 |
| | Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death | Q36751579 |
| | Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy | Q36873680 |
| | Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. | Q36907208 |
| | Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission | Q37117527 |
| | Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril | Q37151315 |
| | Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein. | Q37278078 |
| | Structural and functional characterization of two alpha-synuclein strains | Q37305236 |
| | Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells | Q37446544 |
| | TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation | Q37682407 |
| | The function of α-synuclein | Q38139561 |
| | α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication. | Q38601532 |
| | Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates | Q38631574 |
| | α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading | Q38671037 |
| | Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology | Q38700710 |
| | Heparan sulfate is a cellular receptor for purified infectious prions. | Q40466338 |
| | Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. | Q41015843 |
| | Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies. | Q41378010 |
| | Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity | Q41627077 |
| | α-Synuclein strains cause distinct synucleinopathies after local and systemic administration | Q41681113 |
| | α-Synuclein promotes dilation of the exocytotic fusion pore. | Q41757696 |
| | Cell biology. A unifying role for prions in neurodegenerative diseases | Q41997625 |
| | Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein | Q42116613 |
| | Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes | Q42388077 |
| | Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease | Q43144355 |
| | Transplanted dopaminergic neurons develop PD pathologic changes: a second case report | Q43503056 |
| | Conformational properties of alpha-synuclein in its free and lipid-associated states | Q43564642 |
| | Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype. | Q45990397 |
| | Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal | Q46284513 |
| | MSA prions exhibit remarkable stability and resistance to inactivation | Q46412176 |
| | VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease. | Q46854670 |
| | Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys. | Q46970748 |
| | Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease | Q47169769 |
| | Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy | Q47772222 |
| | Familial Parkinson's point mutation abolishes multiple system atrophy prion replication | Q48347232 |
| | Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. | Q48389356 |
| | Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology | Q48619578 |
| | Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies | Q48659913 |
| | Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells. | Q51294087 |
| | Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity. | Q51744776 |
| | Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging. | Q53191866 |
| | α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons. | Q53827082 |
| | DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins. | Q54958002 |
| | Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates. | Q55511905 |
| | Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy. | Q55617564 |
| | Cryo-EM structure of alpha-synuclein fibrils | Q56811524 |
| | Physiological carboxy-truncation of α-synuclein potentiates the prion-like formation of pathological inclusions | Q57458019 |
| | Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel | Q57909510 |
| | Membrane binding, internalization, and sorting of alpha-synuclein in the cell | Q58783524 |
| | Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies | Q59066979 |
| | Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease | Q64976796 |
| | Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength | Q87866512 |
| | Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy | Q90673210 |
| P433 | issue | 7 | |
| P304 | page(s) | 971-981 | |
| P577 | publication date | 2019-02-13 | |
| P1433 | published in | Laboratory Investigation | Q6467260 |
| P1476 | title | Transmission of α-synuclein seeds in neurodegenerative disease: recent developments | |
| P478 | volume | 99 | |