Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

scientific article published on 07 April 2020

Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.53582
P932PMC publication ID7138607
P698PubMed publication ID32252890

P50authorMasatoshi MiyamotoQ88707494
Akio KiharaQ42656232
Takayuki SassaQ86708529
Megumi SawaiQ88707490
P2860cites workMammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributionsQ24298012
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesisQ24302388
Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamilyQ28118125
Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acidsQ28592642
Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipidsQ28743677
A role for ELOVL4 in the mouse meibomian gland and sebocyte cell biologyQ33558508
Meibum lipid composition in Asians with dry eye diseaseQ34063529
Estimated Prevalence and Incidence of Dry Eye Disease Based on Coding Analysis of a Large, All-age United States Health Care SystemQ91354085
Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide ProductionQ92253364
Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3Q92511300
Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid ω-O-acylceramideQ92889669
Short Tear Film Breakup Time-Type Dry EyeQ93343199
Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formationQ34479815
Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3.Q34488090
The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian glandQ34769303
Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal deathQ35729216
Distribution of mucins at the ocular surfaceQ35755130
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammalsQ35941759
Toward an animal model of the human tear film: biochemical comparison of the mouse, canine, rabbit, and human meibomian lipidomesQ36302985
Laboratory findings in tear fluid analysisQ36413771
Tissue- and stratum-specific expression of the human involucrin promoter in transgenic miceQ36643505
Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid productionQ36978366
Quantitative profiling of major neutral lipid classes in human meibum by direct infusion electrospray ionization mass spectrometryQ37120206
Etiology, prevalence, and treatment of dry eye diseaseQ37288773
Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibumQ37430622
The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease.Q37859544
Very long-chain fatty acids: elongation, physiology and related disordersQ38043980
Tear film lipidsQ38114679
Four characteristics and a model of an effective tear film lipid layer (TFLL).Q38151226
TFOS DEWS II Tear Film Report.Q38652990
Meibomian glands, meibum, and meibogenesisQ38697707
Tear film lipid layer: A molecular level viewQ38742772
Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides.Q38815727
Comparative chemistry of sebumQ39880644
Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.Q40948258
Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum.Q41677978
PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide.Q41898000
Evaluation of the clinical course of dry eye syndromeQ44616226
Involucrin expression in the corneal epithelium: an essential role for Sp1 transcription factorsQ46670198
Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerizationQ46861688
TFOS DEWS II Report Executive Summary.Q46919939
The contribution of lipid layer movement to tear film thinning and breakup.Q51851737
Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice.Q52688144
The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier functionQ57043840
Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (-acyl)-ω-hydroxy fatty acidsQ57172762
The contribution of meibomian disease to dry eyeQ57648466
Spontaneous Eye Blink Patterns in Dry Eye: Clinical CorrelationsQ58125180
Hydrodynamics of blinking. In vitro study of the interaction of the superficial oily layer and the tearsQ71221428
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemiaQ73703942
P921main subjecteye diseaseQ3041498
P577publication date2020-04-07
P1433published ineLifeQ2000008
P1476titleLipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease
P478volume9

Reverse relations

cites work (P2860)
Q98773073Deficiency in Acyl-CoA:Wax Alcohol Acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters
Q112581930Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease
Q114873673Identification of new Omega-3 very long chain poly-unsaturated fatty acids in meibomian gland secretions
Q96613585Interactions of polar lipids with cholesteryl ester multilayers elucidate tear film lipid layer structure
Q102058589Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis
Q100697853Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals

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