Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7

scientific article published on 29 April 2019

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS20092101
P953full work available at URLhttps://www.mdpi.com/1422-0067/20/9/2101
P932PMC publication ID6540042
P698PubMed publication ID31035433

P50authorAlan W StittQ63865513
Mei ChenQ89286774
Sofia PavlouQ117267032
Josy AugustineQ117267033
Heping XuQ41780347
P2093author name stringMei Chen
Heping Xu
Kevin Harkin
Rónán Cunning
P2860cites workRetinal ganglion cell neuronal damage in diabetes and diabetic retinopathy.Q50670549
The P2X7 Receptor.Q50907852
Role of Inflammation in Diabetic Retinopathy.Q52642996
Increased intravitreal adenosine 5′-triphosphate, adenosine 5′-diphosphate and adenosine 5′-monophosphate levels in patients with proliferative diabetic retinopathyQ61970323
Seeing beyond retinopathy in diabetes: electrophysiological and psychophysical abnormalities and alterations in visionQ77139608
ATP-induced photoreceptor death in a feline model of retinal degenerationQ86057189
High fat diet induces pre-type 2 diabetes with regional changes in corneal sensory nerves and altered P2X7 expression and localizationQ89043396
P2RX7 Purinoceptor as a Therapeutic Target-The Second Coming?Q90016514
Global data on visual impairment in the year 2002Q24650312
High glucose modulates P2X7 receptor-mediated function in human primary fibroblastsQ28143914
Neuron-specific distribution of P2X7 purinergic receptors in the monkey retinaQ28186120
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)Q28568856
Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouseQ33645320
The electroretinogram in diabetic retinopathyQ33722276
Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice.Q33995590
Age-related deterioration of rod vision in mice.Q34085363
Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitusQ34523578
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activityQ34757980
P2X(7) receptor in the kidneys of diabetic rats submitted to aerobic training or to N-acetylcysteine supplementation [corrected].Q35190298
Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell deathQ35679315
The progress in understanding and treatment of diabetic retinopathy.Q35752820
Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in MiceQ35830419
Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retinaQ36807663
The P2X7 receptor channel pore dilates under physiological ion conditionsQ36946691
Retinal ganglion cells in diabetesQ37195552
Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retinaQ37236350
Targeting the complement system for the management of retinal inflammatory and degenerative diseases.Q37262287
Neuronal P2X7 Receptors Revisited: Do They Really Exist?Q38659420
Diabetic retinopathy: current understanding, mechanisms, and treatment strategiesQ39445950
CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic RetinopathyQ40594560
Role of inflammation in the pathogenesis of diabetic retinopathyQ41012127
Electrical responses from diabetic retinaQ41736666
HIV drug nucleoside reverse transcriptase inhibitors as promising anti-inflammation therapeutics by targeting P2X7-dependent large pore formation: one stone for two birds?Q42285494
Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetesQ42461966
P2X and P2Y purinoceptor expression in pancreas from streptozotocin-diabetic ratsQ44506085
Enhancement of P2X(7)-induced pore formation and apoptosis: an early effect of diabetes on the retinal microvasculatureQ44777419
The multifocal ERG in diabetic patients without retinopathy during euglycemic clampingQ46568425
P2X7 receptor antagonists protect against N-methyl-D-aspartic acid-induced neuronal injury in the rat retinaQ47732438
The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation.Q48030329
Expression of the P2X7-receptor subunit in neurons of the rat retinaQ48363664
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2101
P577publication date2019-01-01
2019-04-29
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleAttenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7
P478volume20

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Q89591715Genotypic variability in radial resistance to water flow in olive roots and its response to temperature variationscites workP2860

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