Molecular engineering of an efficient four-domain DAF-MCP chimera reveals the presence of functional modularity in RCA proteins

scientific article published on 29 April 2019

Molecular engineering of an efficient four-domain DAF-MCP chimera reveals the presence of functional modularity in RCA proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1818573116
P932PMC publication ID6525521
P698PubMed publication ID31036650

P2093author name stringArvind Sahu
Payel Ghosh
Hemendra Singh Panwar
Hina Ojha
Sagar H Barage
Sunil Raut
P2860cites workIdentification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesisQ24294595
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Structures of C3b in complex with factors B and D give insight into complement convertase formationQ24601226
Structural basis for complement factor I control and its disease-associated sequence polymorphismsQ24622871
Solution structure of a functionally active fragment of decay-accelerating factorQ27640881
Complement regulation at the molecular level: The structure of decay-accelerating factorQ27643002
Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and PathogensQ27664992
Complement. First of two partsQ28210663
Complement and its receptors: new insights into human diseaseQ28307316
Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decayQ28610934
The human complement system: assembly of the classical pathway C3 convertaseQ28610994
Localization of classical and alternative pathway regulatory activity within the decay-accelerating factorQ28611026
Complement: a key system for immune surveillance and homeostasisQ29615484
Crystal structure of the A domain from complement factor B reveals an integrin-like open conformationQ33199380
Complement regulators and inhibitory proteinsQ33386110
Complement regulators in human disease: lessons from modern geneticsQ33419261
The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.Q33422057
Structure-function relationships of complement receptor type 1.Q33952060
Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1.Q33974385
Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteinsQ36179379
Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.Q36906411
Regulation of humoral immunity by complementQ38037801
Viral regulators of complement activation: structure, function and evolutionQ38224425
Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responsesQ38696847
Interaction of C3b, B, and D in the alternative pathway of complement activationQ40343499
A Corresponding Tyrosine Residue in the C2/Factor B Type A Domain Is a Hot Spot in the Decay Acceleration of the Complement C3 ConvertasesQ40625728
Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb.Q40770484
Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b.Q42937991
Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55).Q45145763
Domain swapping reveals complement control protein modules critical for imparting cofactor and decay-accelerating activities in vaccinia virus complement control proteinQ45372266
Influence of electrostatics on the complement regulatory functions of Kaposica, the complement inhibitor of Kaposi's sarcoma-associated herpesvirus.Q51727742
Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)Q57936817
Structure-based Mapping of DAF Active Site Residues That Accelerate the Decay of C3 ConvertasesQ58210854
Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activityQ67701325
Structure-function analysis of the active sites of complement receptor type 1Q74424457
Structure of complement component C2A: implications for convertase formation and substrate bindingQ79207767
P433issue20
P304page(s)9953-9958
P577publication date2019-04-29
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMolecular engineering of an efficient four-domain DAF-MCP chimera reveals the presence of functional modularity in RCA proteins
P478volume116

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Q92513347Spatially conserved motifs in complement control protein domains determine functionality in regulators of complement activation-family proteinscites workP2860

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