Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

scientific article published on 07 April 2020

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.54877
P932PMC publication ID7185992
P698PubMed publication ID32255424

P50authorGökhan M MutluQ88316639
Robert B HamanakaQ90565408
P2093author name stringYan Li
Angelo Y Meliton
Kaitlyn A Sun
Parker S Woods
Lucas M Kimmig
Rengül Cetin-Atalay
P2860cites workImmune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid productionQ24338884
STAR: ultrafast universal RNA-seq alignerQ29615052
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosisQ30581666
Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015Q33711028
RSeQC: quality control of RNA-seq experimentsQ34284787
Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathwayQ35761818
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathwayQ35995696
Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate LevelsQ37065767
Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generationQ37101149
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of InflammationQ37412828
Itaconic acid is a mammalian metabolite induced during macrophage activationQ39118096
Chemical composition of ambient particulate matter and redox activityQ39907174
Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expressionQ40739475
Dimethyl Itaconate Is Not Metabolized into Itaconate IntracellularlyQ46908041
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.Q51331227
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.Q52579425
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.Q52723589
Particulate Matter Air Pollution: Effects on the Cardiovascular SystemQ59798105
Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced ThrombosisQ61799213
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate AccumulationQ91586274
Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathwaysQ92115517
Five national academies call for global compact on air pollution and healthQ92913675
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced InflammationQ93010695
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung FibroblastsQ93025040
P4510describes a project that usesDESeq2Q113018293
P577publication date2020-04-07
P1433published ineLifeQ2000008
P1476titleEndogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response
P478volume9

Reverse relations

cites work (P2860)
Q101225139BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages
Q100746882Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer
Q104139775Exploring the evolutionary roots and physiological function of itaconate
Q104608371High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer
Q112295181Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection
Q101048528Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight
Q97553310TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation
Q108768288The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis

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