| P50 | author | Yangtai Guan | Q79331996 |
| P2093 | author name string | Lan Cao | |
| | Bill Kalionis | |
| | Shijin Xia | |
| | Wenbin Wan | |
| | Padma Murthi | |
| P2860 | cites work | The role of oxidative stress in Parkinson's disease | Q24307946 |
| | Regulation of cellular iron metabolism | Q24610063 |
| | Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease | Q27021700 |
| | “Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A | Q28131712 |
| | Tau-mediated synaptic damage in Alzheimer's disease | Q28831067 |
| | Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease | Q29617286 |
| | Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model | Q29617937 |
| | Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction | Q30821818 |
| | The role of iron in brain ageing and neurodegenerative disorders. | Q30852753 |
| | The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin | Q30989565 |
| | Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment | Q33740552 |
| | Transferrin and transferrin receptor function in brain barrier systems | Q33847801 |
| | Hyperphosphorylation of tau protein in hippocampus of central insulin-resistant rats is associated with cognitive impairment. | Q50703159 |
| | Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells. | Q51983113 |
| | Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease. | Q52009127 |
| | Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. | Q53218504 |
| | Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons | Q74154135 |
| | Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase | Q77944438 |
| | Effect of neurturin deficiency on cholinergic and catecholaminergic innervation of the murine eye | Q87494446 |
| | Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes | Q33859600 |
| | Neuroprotective effect of the active components of three Chinese herbs on brain iron load in a mouse model of Alzheimer's disease | Q34043487 |
| | Amyloid-beta: a crucial factor in Alzheimer's disease. | Q34451907 |
| | Insulin resistance in Alzheimer's disease | Q34622157 |
| | Does diabetes protect or provoke Alzheimer's disease? Insights into the pathobiology and future treatment of Alzheimer's disease | Q35618911 |
| | Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial | Q35679839 |
| | Alzheimer's disease: the two-hit hypothesis | Q35708114 |
| | Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline | Q35858095 |
| | Insulin signaling and the regulation of glucose transport. | Q36321818 |
| | Iron in skin of mice with three etiologies of systemic iron overload. | Q36459893 |
| | Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions | Q36521690 |
| | Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease | Q36821001 |
| | Iron metabolism, oxidative stress, and neonatal brain injury | Q36996578 |
| | Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease | Q37141206 |
| | Insulin concentration is critical in culturing human neural stem cells and neurons. | Q37148293 |
| | Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice | Q37235613 |
| | MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice | Q37295234 |
| | Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease | Q37332266 |
| | Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features | Q37364099 |
| | Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction | Q37587232 |
| | Iron in neuronal function and dysfunction | Q37709937 |
| | Review on iron and its importance for human health | Q37723220 |
| | The role of metallobiology and amyloid-β peptides in Alzheimer's disease | Q37961769 |
| | The metal theory of Alzheimer's disease | Q38013572 |
| | Insulin and the brain | Q38066536 |
| | Genetics of familial and sporadic Alzheimer's disease | Q38070538 |
| | Insulin resistance: an emerging link in Alzheimer's disease | Q38106633 |
| | The neuropathology of neurodegeneration with brain iron accumulation | Q38161017 |
| | Transport and diffusion of Tau protein in neurons | Q38200941 |
| | Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis. | Q38219289 |
| | Role of insulin resistance in Alzheimer's disease. | Q38268394 |
| | EGb761 improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse | Q38768819 |
| | Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation | Q38841738 |
| | Aβ(1-42) oligomer-induced leakage in an in vitro blood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins | Q38888246 |
| | Alpha-synuclein and iron: two keys unlocking Parkinson's disease. | Q39123736 |
| | Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. | Q39171874 |
| | Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease | Q39327923 |
| | Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake | Q39341568 |
| | Oxidative stress partially contributes to iron-induced α-synuclein aggregation in SK-N-SH cells | Q39716036 |
| | Tau aggregation and toxicity in a cell culture model of tauopathy | Q40146754 |
| | Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease | Q41117111 |
| | Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation | Q41515458 |
| | Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology. | Q42118844 |
| | Chromium-containing traditional Chinese medicine, Tianmai Xiaoke Tablet improves blood glucose through activating insulin-signaling pathway and inhibiting PTP1B and PCK2 in diabetic rats | Q42224366 |
| | The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia. | Q43548494 |
| | Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. | Q43616611 |
| | Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures. | Q44305654 |
| | Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3. | Q45234671 |
| | Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease. | Q45335656 |
| | The Western Blot | Q46075374 |
| | Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation | Q46412461 |
| | Serum Iron, Zinc, and Copper Levels in Patients with Alzheimer's Disease: A Replication Study and Meta-Analyses | Q46458603 |
| | Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease | Q46531893 |
| | Comparison of antioxidant activity of insulin, Ocimum gratissimum L., and Vernonia amygdalina L. in type 1 diabetic rat model | Q46698456 |
| | Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease | Q46815056 |
| | Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. | Q46852229 |
| | Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons. | Q47623946 |
| | Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study | Q47855821 |
| | Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain | Q48243458 |
| | Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes | Q48393451 |
| | Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease | Q48404181 |
| | Beta amyloid-induced upregulation of death receptor 6 accelerates the toxic effect of N-terminal fragment of amyloid precursor protein | Q48588905 |
| | Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type | Q48609353 |
| | Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease | Q48671019 |
| | Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice | Q48721169 |
| | Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease | Q48820847 |
| | Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease | Q48873897 |
| | Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ? | Q50034896 |
| | Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects | Q50199042 |
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P304 | page(s) | 607 | |
| P577 | publication date | 2019-06-19 | |
| P1433 | published in | Frontiers in Neurology | Q15817039 |
| P1476 | title | Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling | |
| P478 | volume | 10 | |