Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice

scientific article published on 05 December 2019

Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-54971-9
P932PMC publication ID6895090
P698PubMed publication ID31804596

P2093author name stringRuth Gabizon
Hanna Rosenmann
Kati Frid
Orli Binyamin
Yael Ungar
Keren Nitzan
P2860cites workThe Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative DiseasesQ26750137
Fatal prion disease in a mouse model of genetic E200K Creutzfeldt-Jakob diseaseQ27348644
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegenerationQ28140796
Neurotoxicity induces cleavage of p35 to p25 by calpainQ28145382
Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acidQ28253158
Cdk5 activity in the brain - multiple paths of regulationQ33687591
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse modelQ33960315
Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer diseaseQ34107259
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse modelsQ34418781
Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer ProfileQ35577702
beta-Secretase, APP and Abeta in Alzheimer's disease.Q36040315
Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventionsQ36212516
Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidantQ36332494
Involvement of calpain activation in neurodegenerative processes.Q36588397
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer diseaseQ36740290
Prion diseases: from protein to cell pathologyQ37075786
Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicityQ37177242
Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse modelQ37341124
Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic MiceQ37610732
The interplay between mitochondrial dynamics and mitophagyQ37815475
Cytochrome c oxidase and its role in neurodegeneration and neuroprotectionQ38021402
Are oxidative stress and mitochondrial dysfunction the key players in the neurodegenerative diseases?Q38027902
Genetic mouse models of brain ageing and Alzheimer's diseaseQ38173230
Experimental Models of Inherited PrP Prion DiseasesQ39092626
Effect of conjugated linoleic acid, μ-calpain inhibitor, on pathogenesis of Alzheimer's diseaseQ39224973
Cyclin dependent kinase 5: A novel avenue for Alzheimer's diseaseQ39319073
Mitochondrial Respiration Is Impaired during Late-Stage Hamster Prion InfectionQ40141938
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progressionQ40301497
Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the ratQ40416447
Development and therapeutic potential of calpain inhibitorsQ41188037
Targeting Cdk5 activity in neuronal degeneration and regenerationQ41720010
Incorporation and metabolism of punicic acid in healthy young humans.Q43276731
Differential neurobehavioral deficits induced by apomorphine and its oxidation product, 8-oxo-apomorphine-semiquinone, in rats.Q44014663
Incorporation of conjugated linoleic acid into brain lipids is not necessary for conjugated linoleic acid-induced reductions in feed intake or body fat in miceQ44980817
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in ratsQ45268625
Punicic acid from Trichosanthes kirilowii seed oil is rapidly metabolized to conjugated linoleic acid in rats.Q46002371
Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.Q46927043
Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates.Q47562648
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's diseaseQ47714762
Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndromeQ47739915
Aged Tg2576 mice are impaired on social memory and open field habituation testsQ48317805
Evidence for early cognitive impairment related to frontal cortex in the 5XFAD mouse model of Alzheimer's disease.Q48346702
Assessment of spatial memory using the T mazeQ48347939
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.Q48404445
On the delay-dependent involvement of the hippocampus in object recognition memoryQ48542116
Phos-tau peptide immunization of amyloid-tg-mice reduced non-mutant phos-tau pathology, improved cognition and reduced amyloid plaquesQ50060997
Continues administration of Nano-PSO significantly increased survival of genetic CJD mice.Q50494246
Prions, prionoids and protein misfolding disorders.Q54224345
Punicic acid was metabolised and incorporated in the form of conjugated linoleic acid in different rat tissuesQ57453356
Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based testsQ60912224
Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodiesQ60932604
Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in NeurodegenerationQ64096411
The Prion DiseasesQ85180476
Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJDQ87620152
Resident brain neural precursor cells develop age-dependent loss of therapeutic functions in Alzheimer's miceQ91387633
Comparison of β-Amyloid Plaque Labeling Methods: Antibody Staining, Gallyas Silver Staining, and Thioflavin-S StainingQ91853789
Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment?Q93038367
P2507corrigendum / erratumAuthor Correction: Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD miceQ92890179
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)18437
P577publication date2019-12-05
P1433published inScientific ReportsQ2261792
P1476titleBrain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice
P478volume9

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