Triptolide potentiates the cytoskeleton-stabilizing activity of cyclosporine A in glomerular podocytes via a GSK3β dependent mechanism

scientific article published on 15 March 2020

Triptolide potentiates the cytoskeleton-stabilizing activity of cyclosporine A in glomerular podocytes via a GSK3β dependent mechanism is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID7137037
P698PubMed publication ID32269713

P2093author name stringPei Wang
Rujun Gong
Zhangsuo Liu
Yan Ge
Lance D Dworkin
Deepak K Malhotra
Bohan Chen
Xianhui Liang
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The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathyQ36803722
The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy?Q37036457
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GSK3, snail, and adhesion molecule regulation by cyclosporine A in renal tubular cells.Q39380020
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Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.Q39717376
Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cellsQ39816126
Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53.Q39994742
Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injuryQ41601375
Cytoskeletal changes in podocytes associated with foot process effacement in Masugi nephritis.Q42049689
Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against PodocytopathyQ42141815
Reactive oxygen species-regulated glycogen synthase kinase-3β activation contributes to all-trans retinoic acid-induced apoptosis in granulocyte-differentiated HL60 cells.Q42233579
Cyclosporine A-induced apoptosis in renal tubular cells is related to oxidative damage and mitochondrial fissionQ42713264
Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathyQ43059651
Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockadeQ46466275
Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitroQ46570250
High glucose-induced apoptosis through store-operated calcium entry and calcineurin in human umbilical vein endothelial cellsQ46769099
Triptolide attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage.Q46835698
Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR PathwayQ46968759
Efficacy and safety of Tripterygium wilfordii Hook F for CKD in Mainland China: A systematic review and meta-analysis.Q48201892
The Evolving Complexity of the Podocyte CytoskeletonQ50231801
The Effectiveness and Safety of Tripterygium wilfordii Hook. F Extracts in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.Q55004397
Traditional Chinese Medicine for Refractory Nephrotic Syndrome: Strategies and Promising Treatments.Q55005671
Efficacy and Safety of Tripterygium Wilfordii Hook F on Psoriasis Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Q55042900
A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F.Q55407628
Triptolide Attenuates Renal Tubular Epithelial-mesenchymal Transition Via the MiR-188-5p-mediated PI3K/AKT Pathway in Diabetic Kidney DiseaseQ58758555
A PRISMA-compliant systematic review and network meta-analysis on the efficacy between different regimens based on Tripterygium wilfordii Hook F in patients with primary nephrotic syndrome.Q64932016
Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordiiQ70479646
Role of peroxynitrite in endothelial damage mediated by Cyclosporine AQ79517466
Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signalingQ82597123
P4510describes a project that usesImageJQ1659584
P433issue3
P921main subjectcyclosporineQ367700
P304page(s)800-812
P577publication date2020-03-15
P1433published inAmerican Journal of Translational ResearchQ4744272
P1476titleTriptolide potentiates the cytoskeleton-stabilizing activity of cyclosporine A in glomerular podocytes via a GSK3β dependent mechanism
P478volume12

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