Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation

scientific article published on 24 September 2019

Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/ACSCENTSCI.9B00567
P932PMC publication ID6891849
P698PubMed publication ID31807678

P50authorKaitlin KentalaQ87616276
Jared C LewisQ87826882
P2093author name stringMichael W Beck
Bryan C Dickinson
Weiwei An
Alexander R Lippert
Krysten A Jones
P2860cites workMeaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsQ24532168
Bimolecular fluorescence complementation (BiFC): a 5-year update and future perspectivesQ27009598
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAPQ27732817
Principles of protein-protein interactionsQ27860855
Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementationQ28244717
A split horseradish peroxidase for the detection of intercellular protein-protein interactions and sensitive visualization of synapsesQ28276002
Reaching for high-hanging fruit in drug discovery at protein-protein interfacesQ29547258
The synaptic vesicle cycle: a cascade of protein-protein interactionsQ29620168
In vivo and in vitro protein solubility assays using split GFP.Q30824549
Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.Q31856730
Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactionsQ32123133
Bright building blocks for chemical biologyQ33551601
Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes.Q33612449
A synthetic luciferin improves bioluminescence imaging in live miceQ33631918
Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug.Q33726983
Split-protein systems: beyond binary protein-protein interactionsQ34070966
Modular extracellular sensor architecture for engineering mammalian cell-based devicesQ34167797
Selective esterase-ester pair for targeting small molecules with cellular specificityQ34192621
Small-molecule inhibitors of protein-protein interactions: progressing toward the realityQ34263719
Visualization of molecular interactions using bimolecular fluorescence complementation analysis: characteristics of protein fragment complementationQ34305981
Kinetics-Based Measurement of Hypoxia in Living Cells and Animals Using an Acetoxymethyl Ester Chemiluminescent ProbeQ90010746
Multicenter open-label randomized phase II study of second-line panitumumab and irinotecan with or without fluoropyrimidines in patients with KRAS wild-type metastatic colorectal cancer (PACIFIC study)Q90291999
Rational Design and Facile Synthesis of a Highly Tunable Quinoline-Based Fluorescent Small-Molecule Scaffold for Live Cell ImagingQ90360647
Design of fast proteolysis-based signaling and logic circuits in mammalian cellsQ90371724
Phase II Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory NeuroblastomaQ90858653
Evolution of C-Terminal Modification Tolerance in Full-Length and Split T7 RNA Polymerase BiosensorsQ91265775
Recent Advances and Challenges in Luminescent Imaging: Bright Outlook for Chemiluminescence of Dioxetanes in WaterQ91535198
A split-Cas9 architecture for inducible genome editing and transcription modulationQ34460920
Engineering the ABA plant stress pathway for regulation of induced proximityQ35031343
Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientistQ35610650
Cell-free synthetic biology: thinking outside the cellQ35878115
Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell linesQ35902206
New methodologies for measuring protein interactions in vivo and in vitroQ36046401
Cell type-specific pharmacology of NMDA receptors using masked MK801.Q36124201
Visualizing cellular interactions with a generalized proximity reporterQ36884190
A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.Q37015065
Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic NeuroblastomaQ37718554
Interactome mapping for analysis of complex phenotypes: insights from benchmarking binary interaction assaysQ38010411
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.Q38172752
Split-luciferase complementary assay: applications, recent developments, and future perspectivesQ38227133
Mapping biochemical networks with protein fragment complementation assaysQ38414226
ABT-199 (venetoclax) and BCL-2 inhibitors in clinical developmentQ38640917
Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancerQ38898663
A new non-disruptive strategy to target calcium indicator dyes to the endoplasmic reticulumQ39881694
Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.Q40016903
Antitumor activity of edotecarin in breast carcinoma modelsQ40211112
NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in CellsQ40319794
Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapyQ40418398
Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapyQ40612485
Unlocking the Potential of Chemiluminescence ImagingQ42357520
Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesteraseQ43657345
Ester bonds in prodrugsQ44937687
A general method to fine-tune fluorophores for live-cell and in vivo imagingQ45066487
Fluorogenic Targeting of Voltage-Sensitive Dyes to Neurons.Q46400196
Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolismQ46678390
Synthesis and Evaluation as Prodrugs of Hydrophilic Carbamate Ester Analogues of ResveratrolQ46687732
Survival Outcomes According to TIMP1 and EGFR Expression in Heavily Treated Patients with Advanced Non-small Cell Lung Cancer who Received Biweekly Irinotecan Plus BevacizumabQ47613628
RNA Polymerase Tags To Monitor Multidimensional Protein-Protein Interactions Reveal Pharmacological Engagement of Bcl-2 Proteins.Q47853163
Multidimensional Control of Cas9 by Evolved RNA Polymerase-Based Biosensors.Q47951224
Phase II study of nedaplatin and irinotecan as adjuvant chemotherapy for completely resected non-small cell lung cancerQ50109053
A "Caged" Luciferin for Imaging Cell-Cell Contacts.Q50961156
Evolution of a split RNA polymerase as a versatile biosensor platform.Q51006974
Irinotecan and temozolomide in recurrent Ewing sarcoma: an analysis in 51 adult and pediatric patients.Q52658441
A versatile esterase from Bacillus subtilis: cloning, expression, characterization, and its application in biocatalysis.Q54451222
Continuous directed evolution of proteins with improved soluble expressionQ56873918
Cell-Specific Chemical Delivery Using a Selective Nitroreductase–Nitroaryl PairQ59918601
Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactionsQ64079530
Inhibitors of protein-protein interactions (PPIs): an analysis of scaffold choices and buried surface area.Q64892301
Novel anthracycline-spacer-beta-glucuronide,-beta-glucoside, and -beta-galactoside prodrugs for application in selective chemotherapyQ78246228
Phase II study of irinotecan and amrubicin in patients with relapsed non-small cell lung cancer: Okayama Lung Cancer Study Group Trial 0402Q83339502
P433issue11
P921main subjectprotein-protein interactionQ896177
P304page(s)1768-1776
P577publication date2019-09-24
P1433published inACS Central ScienceQ27726586
P1476titleDevelopment of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation
P478volume5

Reverse relations

Q91742508A Novel Split Reporter Uncages New Possibilitiescites workP2860

Search more.