Hemorrhagic Shock Sensitized the Diaphragm to Ventilator-Induced Dysfunction through the Activation of IL-6/JAK/STAT Signaling-Mediated Autophagy in Rats

scientific article published on 14 November 2019

Hemorrhagic Shock Sensitized the Diaphragm to Ventilator-Induced Dysfunction through the Activation of IL-6/JAK/STAT Signaling-Mediated Autophagy in Rats is …
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scholarly articleQ13442814

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P356DOI10.1155/2019/3738409
P932PMC publication ID6878811
P698PubMed publication ID31814800

P50authorLi-Juan ZhangQ91790008
Xian-Long ZhouQ91790013
Yan ZhaoQ91790018
P2093author name stringShao-Zhou Ni
P2860cites workAutophagy in the Pathogenesis of DiseaseQ27860558
p-Hydroxyphenylpyruvate, an intermediate of the Phe/Tyr catabolism, improves mitochondrial oxidative metabolism under stressing conditions and prolongs survival in rats subjected to profound hemorrhagic shockQ28540531
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearanceQ28578993
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injuryQ28579843
Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant productionQ34003272
Diaphragmatic function is preserved during severe hemorrhagic shock in the rat.Q35012079
The JAK-STAT pathway is critical in ventilator-induced diaphragm dysfunctionQ35192843
Clinical review: ventilator-induced diaphragmatic dysfunction--human studies confirm animal model findings!Q35559303
STAT3 as a new autophagy regulatorQ37168124
IL-6 predicts organ dysfunction and mortality in patients with multiple injuries.Q37389649
Autophagy and cytokinesQ37926024
Ventilator-induced diaphragm dysfunction: cause and effectQ38120655
Reactive oxygen species regulation of autophagy in skeletal musclesQ39067935
Rapid onset of specific diaphragm weakness in a healthy murine model of ventilator-induced diaphragmatic dysfunctionQ39590938
A new mouse model of hemorrhagic shock-induced acute kidney injuryQ40399919
Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation.Q44915757
Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation.Q46249490
Dihydralazine treatment limits liver injury after hemorrhagic shock in ratsQ46978649
Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical OutcomesQ47767741
Mechanical ventilation-induced diaphragm disuse in humans triggers autophagyQ48123019
The grapes and wrath: using resveratrol to treat the pathophysiology of hemorrhagic shockQ48169996
Mechanical ventilation results in progressive contractile dysfunction in the diaphragm.Q49138692
Preliminary profiling of blood transcriptome in a rat model of hemorrhagic shockQ50326043
Dimethyl Sulfoxide Attenuates Acute Lung Injury Induced by Hemorrhagic Shock/Resuscitation in Rats.Q51232011
Relationship between Autophagy and Ventilator-induced Diaphragmatic Dysfunction.Q51305465
N-Acetylcysteine and Desferoxamine Reduce Pulmonary Oxidative Stress Caused by Hemorrhagic Shock in a Porcine Model.Q51419764
Prolonged mechanical ventilation worsens sepsis-induced diaphragmatic dysfunction in the rat.Q64936299
Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction.Q64967700
Systemic effects of unspecific inflammatory reaction at traumatic brain injuryQ88049860
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectautophagyQ288322
hemorrhagic shockQ2964243
P304page(s)3738409
P577publication date2019-11-14
P1433published inMediators of InflammationQ2144494
P1476titleHemorrhagic Shock Sensitized the Diaphragm to Ventilator-Induced Dysfunction through the Activation of IL-6/JAK/STAT Signaling-Mediated Autophagy in Rats
P478volume2019

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