High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer

scientific article published on 11 July 2019

High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1186/S13046-019-1288-7
P932PMC publication ID6625066
P698PubMed publication ID31296258

P2093author name stringXin Chen
Zheng Wang
Jie Li
Liang Cheng
Zheng Wu
Qingyong Ma
Wanxing Duan
Xuqi Li
Jiguang Ma
Zhengdong Jiang
Cancan Zhou
Weikun Qian
P2860cites workAutophagy fights disease through cellular self-digestionQ27860902
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Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signalingQ33856101
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Hyperglycemic tumor microenvironment induces perineural invasion in pancreatic cancerQ36214692
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor GrowthQ36275975
Expanding roles for SREBP in metabolismQ36303731
The Relevance of Nrf2 Pathway and Autophagy in Pancreatic Cancer Cells upon Stimulation of Reactive Oxygen Species.Q36349182
Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortiumQ36487491
Low glucose dependent decrease of apoptosis and induction of autophagy in breast cancer MCF-7 cellsQ36952559
Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen PeroxideQ37084377
Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad SignalingQ37187410
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicityQ37573880
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SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiformeQ38301499
Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challengesQ38680160
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic CancerQ39078244
Hyperglycemia enhances the invasive and migratory activity of pancreatic cancer cells via hydrogen peroxideQ39605380
High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cellsQ39642080
Metabolism meets autophagyQ42780796
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.Q42874599
Chronic pancreatitis and pancreatic cancer: prediction and mechanismQ43246769
Sterol regulatory element-binding protein 1 is required for ovarian tumor growthQ46165086
Autophagy is involved in regulating VEGF during high-glucose-induced podocyte injuryQ46554485
Systematic review of pancreatic cancer epidemiology in Asia-Pacific Region: major patterns in GLOBACON 2012.Q49397791
Early Diagnosis to Improve the Poor Prognosis of Pancreatic Cancer.Q50034076
Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions.Q52627243
Sterol regulatory element-binding protein 1 cooperates with c-Myc to promote epithelial-mesenchymal transition in colorectal cancer.Q52647695
Autophagy, Metabolism, and Cancer.Q53210815
Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma.Q55424250
Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinomaQ57782075
Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent SignalingQ57790539
Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1Q57809718
Diabetes and cancer: Pathophysiological fundamentals of a ‘dangerous affair’Q58456992
Hyperglycemia aggravates microenvironment hypoxia and promotes the metastatic ability of pancreatic cancerQ59136790
Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism RevisitedQ60919715
Pancreatic adenocarcinomaQ86062298
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2Q89486016
Cancer statistics, 2019Q90941571
Silibinin inhibits endometrial carcinoma via blocking pathways of STAT3 activation and SREBP1-mediated lipid accumulationQ93213005
P433issue1
P921main subjectautophagyQ288322
pancreatic cancerQ212961
P304page(s)302
P577publication date2019-07-11
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleHigh glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer
P478volume38

Reverse relations

cites work (P2860)
Q92153393Disruption of Cancer Metabolic SREBP1/miR-142-5p Suppresses Epithelial-Mesenchymal Transition and Stemness in Esophageal Carcinoma
Q90418318Immune infiltration in nasopharyngeal carcinoma based on gene expression

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