Altered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T Cells

scientific article published on 22 February 2019

Altered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T Cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2337/DB18-0487
P932PMC publication ID6477900
P698PubMed publication ID30796028

P50authorF. Susan WongQ63411298
Dimitri KakabadseQ86706204
Larissa Camargo Da RosaQ86834124
Li WenQ88313570
P2093author name stringJian Peng
Mark Lewis
Joanne Davies
Simone Cuff
James A Pearson
Jeremy Warden-Smith
P2860cites workLow incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiomeQ21132451
Innate immunity and intestinal microbiota in the development of Type 1 diabetesQ24647312
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetesQ27676742
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoiresQ28590409
Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese miceQ28730963
Bifidobacteria can protect from enteropathogenic infection through production of acetateQ29617592
A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteinsQ30439422
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.Q30763625
Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinaseQ31131014
Prime role for an insulin epitope in the development of type 1 diabetes in NOD miceQ34345367
Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged SiteQ34490115
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD miceQ34968027
Long term effect of gut microbiota transfer on diabetes developmentQ35157830
Aberrant gut microbiota composition at the onset of type 1 diabetes in young childrenQ35188386
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.Q35191064
Antibiotic treatment of pregnant non-obese diabetic mice leads to altered gut microbiota and intestinal immunological changes in the offspringQ35195054
Peripheral education of the immune system by colonic commensal microbiota.Q35341308
Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice.Q35554609
The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetesQ35557877
Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetesQ35603139
A single autoimmune T cell receptor recognizes more than a million different peptidesQ35668865
Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCsQ35786213
Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific ImmunityQ35801381
Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatmentQ35816663
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in HumansQ36004640
Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD miceQ36017830
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetesQ36323689
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.Q36366075
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic miceQ36380895
Analysis of the spontaneous T cell response to insulin in NOD miceQ36719300
Fecal microbiota composition differs between children with β-cell autoimmunity and those withoutQ36720600
Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD miceQ36736666
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitopeQ36890836
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivityQ36951745
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiotaQ37011757
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetesQ37163535
Microbial antigen mimics activate diabetogenic CD8 T cells in NOD miceQ37272130
Gender bias in autoimmunity is influenced by microbiota.Q37294725
Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.Q37643235
Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes.Q40586866
T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjectsQ40953888
Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse.Q41103039
A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis.Q46279244
Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice.Q46691699
Cloned T cells from a recent onset IDDM patient reactive with insulin B-chainQ47896791
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in miceQ48038122
Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse.Q51369994
The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse.Q53524050
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity.Q54468190
The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypesQ80972975
Identification of Islet Antigen-Specific CD8 T Cells Using MHCI-Peptide Tetramer Reagents in the Non Obese Diabetic (NOD) Mouse Model of Type 1 DiabetesQ86894424
P433issue5
P1104number of pages12
P304page(s)1002-1013
P577publication date2019-02-22
P1433published inDiabetesQ895262
P1476titleAltered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T Cells
P478volume68

Reverse relations

cites work (P2860)
Q99593673CD8 T cells drive anorexia, dysbiosis, and blooms of a commensal with immunosuppressive potential after viral infection
Q91711356Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms
Q93047734How the Interplay Between the Commensal Microbiota, Gut Barrier Integrity, and Mucosal Immunity Regulates Brain Autoimmunity
Q91670627Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell Functions

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