Pharmacokinetic analysis of new synthetic antimalarial N-251

scientific article published on 05 July 2019

Pharmacokinetic analysis of new synthetic antimalarial N-251 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S41182-019-0167-4
P932PMC publication ID6611044
P698PubMed publication ID31312098

P50authorHye-Sook KimQ91938131
P2093author name stringAkira Sato
Akiko Hiramoto
Kazutaka Higaki
Shin-Ichi Miyoshi
Yuji Kurosaki
Kyung-Soo Chang
Rena Isogawa
Kazuaki Okada
P2860cites workQinghaosu (Artemisinin): The Price of SuccessQ21032496
Artemisinin Resistance in Plasmodium falciparum MalariaQ22061852
Evidence of Artemisinin-Resistant Malaria in Western CambodiaQ22061854
Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal studyQ24598695
The global distribution of clinical episodes of Plasmodium falciparum malariaQ24599466
Identification of an endoplasmic reticulum-resident calcium-binding protein with multiple EF-hand motifs in asexual stages of Plasmodium falciparumQ27973612
Qinghaosu (artemisinin): an antimalarial drug from ChinaQ34193570
Medical need, scientific opportunity and the drive for antimalarial drugsQ34521004
Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsomeQ36246585
The threat of artemisinin-resistant malariaQ37069786
Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependentQ37138144
Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparumQ39269574
Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-olQ39556880
Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5, 7-pentoxocanes and 1,2,4,5-tetroxanesQ40941195
Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.Q41696128
Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanesQ43655345
Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drugQ46883171
Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N-89 and N-251.Q48022527
A pharmacokinetic analysis program (multi) for microcomputerQ52732710
Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: utilization of a more suitable medium for in-vitro dissolution studyQ80177342
Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery SystemQ86830674
P921main subjectpharmacokineticsQ323936
P304page(s)40
P577publication date2019-07-05
P1433published inTropical Medicine and HealthQ6158243
P1476titlePharmacokinetic analysis of new synthetic antimalarial N-251
P478volume47

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