The Role and Function of Ras-association domain family in Cancer: A Review

scientific article published on 27 July 2019

The Role and Function of Ras-association domain family in Cancer: A Review is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.GENDIS.2019.07.008
P932PMC publication ID6889020
P698PubMed publication ID31832517

P50authorMohammad Reza ZinatizadehQ91940288
P2093author name stringMohammad Esmaeil Akbari
Hamid Reza Mirzaei
Ghanbar Mahmoodi Chalbatani
Hassan Dana
Seyed Rouhollah Miri
Seyed Ali Momeni
Peyman Kheirandish Zarandi
P2860cites workThe putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1Q24292345
Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activationQ24295079
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and AktQ24296477
The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulationQ24297959
RASSF2 is a novel K-Ras-specific effector and potential tumor suppressorQ24301371
The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell deathQ24305092
Identification of Nore1 as a potential Ras effectorQ24314874
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complexQ24323508
Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activityQ24336042
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by RasQ24338128
RASSF2 associates with and stabilizes the proapoptotic kinase MST2Q24338394
The Hippo Signaling Pathway in Development and CancerQ24603986
Nore1B regulates TCR signaling via Ras and Carma1Q24633118
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor proteinQ24648062
Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosisQ28139203
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomasQ28190533
Targeting RAS signalling pathways in cancer therapyQ28201363
Identification of a novel Ras-regulated proapoptotic pathwayQ28203664
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.Q38956821
RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progressionQ39004151
Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signalQ39108870
The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53.Q39347028
ATM regulates a RASSF1A-dependent DNA damage responseQ39766802
Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.Q39817336
NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A.Q39899665
Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.Q40009864
Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migrationQ40089954
Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathwaysQ40157708
RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.Q40485735
Aberrant methylation of RASSF4/AD037 in nasopharyngeal carcinoma.Q40514524
A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stabilityQ40543835
Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in miceQ42416763
NORE1A tumor suppressor candidate modulates p21CIP1 via p53.Q42799756
The cellular apoptosis susceptibility CAS/CSE1L gene protects ovarian cancer cells from death by suppressing RASSF1C.Q44451511
Tumor susceptibility of Rassf1a knockout miceQ45234570
RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.Q45939520
A polymorphism at codon 133 of the tumor suppressor RASSF1A is associated with tumorous alteration of the breast.Q46533945
Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidyQ47603610
DNA methylation biomarkers of prostate cancer: confirmation of candidates and evidence urine is the most sensitive body fluid for non-invasive detectionQ47753069
Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinasesQ47984176
RASSF1A Suppresses Cell Migration through Inactivation of HDAC6 and Increase of Acetylated α-TubulinQ47986980
RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer.Q50752468
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.Q53347351
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancerQ53649603
RASSF1C, an Isoform of the Tumor Suppressor RASSF1A, Promotes the Accumulation of β-Catenin by Interacting with βTrCPQ61824843
Serine phosphorylation-regulated ubiquitination and degradation of beta-cateninQ73735409
Recognizing and defining true Ras binding domains I: biochemical analysisQ81643533
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenesQ28265486
RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamicsQ28267593
NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinomaQ28300321
RASSF6 is a novel member of the RASSF family of tumor suppressorsQ28509722
Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1Q28592139
Acetylation: a regulatory modification to rival phosphorylation?Q29614886
NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.Q30370843
A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcomaQ30413809
The growth and tumor suppressors NORE1A and RASSF1A are targets for calpain-mediated proteolysisQ30440607
Microtubule segment stabilization by RASSF1A is required for proper microtubule dynamics and Golgi integrityQ30574008
RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriersQ33708522
The Ras effector RASSF2 controls the PAR-4 tumor suppressorQ33877015
Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical ApproachQ33888064
Tumor Suppressor Ras Association Domain Family 5 (RASSF5/NORE1) Mediates Death Receptor Ligand-induced ApoptosisQ34251431
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell traffickingQ34347604
The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancerQ34433428
Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.Q34467504
The RASSF1A tumor suppressor activates Bax via MOAP-1.Q34475337
Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomasQ34650707
Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemiaQ34798023
The RASSF1A tumor suppressor regulates XPA-mediated DNA repairQ34968548
Death pathways triggered by activated Ras in cancer cellsQ34994888
Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancerQ35075615
Drugging the undruggable RAS: Mission possible?Q35163434
EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.Q35238478
Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destructionQ35576291
RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cellsQ36216004
The RASSF1A tumor suppressorQ36945316
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.Q37010249
Gene expression profiling of the 8q22-24 position in human breast cancer: TSPYL5, MTDH, ATAD2 and CCNE2 genes are implicated in oncogenesis, while WISP1 and EXT1 genes may predict a risk of metastasisQ37407194
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppressionQ37410567
Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neckQ37625248
Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.Q37761824
The Hippo pathway and human cancer.Q38087215
P433issue4
P304page(s)378-384
P577publication date2019-07-27
P1476titleThe Role and Function of Ras-association domain family in Cancer: A Review
P478volume6