Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel

scientific article published on 15 April 2020

Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel is …
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P356DOI10.1038/S41598-020-63577-5
P932PMC publication ID7160154
P698PubMed publication ID32296107

P50authorMustafa NazıroğluQ88072810
P2093author name stringYener Akyuva
P2860cites workADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homologyQ24291275
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagentQ28248838
Determination of mitochondrial membrane potential and reactive oxygen species in live rat cortical neuronsQ35128375
Resveratrol protects PC12 cells against OGD/ R-induced apoptosis via the mitochondrial-mediated signaling pathwayQ35951625
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injuryQ36764414
Role of TRPM2 in cell proliferation and susceptibility to oxidative stressQ36899622
Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagyQ37535690
Molecular role of catalase on oxidative stress-induced Ca(2+) signaling and TRP cation channel activation in nervous systemQ37999843
Calcium ion--the key player in cerebral ischemiaQ38174098
Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria.Q38690103
Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and BioenergeticsQ38742845
Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedureQ38751394
Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cellsQ38786954
Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activationQ38847864
Resveratrol attenuates hypoxia/reoxygenation‑induced Ca2+ overload by inhibiting the Wnt5a/Frizzled‑2 pathway in rat H9c2 cellsQ38966395
SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cellsQ39624115
Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels.Q39881941
Curcumin inhibits apoptosis by regulating intracellular calcium release, reactive oxygen species and mitochondrial depolarization levels in SH-SY5Y neuronal cellsQ40273636
Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activationQ40677462
Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons.Q41981569
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine releaseQ42325393
TRPM2 Promotes Neurotoxin MPP+/MPTP-Induced Cell Death.Q46446881
Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of RatsQ46461382
Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of γ-irradiated rat.Q46565261
Dihydromyricetin Improves Hypobaric Hypoxia-Induced Memory Impairment via Modulation of SIRT3 SignalingQ46621629
A calcium influx pathway regulated separately by oxidative stress and ADP-Ribose in TRPM2 channels: single channel eventsQ46764885
Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of TRPM2 and TRPV1 channelsQ46826776
Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral PainQ47868681
Glutathione peroxidase activity in selenium-deficient rat liver. 1976.Q48396142
Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.Q48825442
The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal ApoptosisQ49137881
CoCl2 increases the expression of hypoxic markers HIF-1α, VEGF and CXCR4 in breast cancer MCF-7 cellsQ49386878
DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol-mediated cardioprotection against hypoxia/reoxygenation-induced oxidative stressQ49492247
Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neuronsQ50130119
Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential ChannelsQ50319836
Aminoethoxydiphenyl borate and flufenamic acid inhibit Ca2+ influx through TRPM2 channels in rat dorsal root ganglion neurons activated by ADP-ribose and rotenone.Q52719113
Melatonin as a stabilizer of mitochondrial function: role in diseases and agingQ58523691
Resveratrol mitigates the oxidative stress mediated by hypoxic-ischemic brain injury in neonatal rats via Nrf2/HO-1 pathwayQ59336217
Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell DeathQ61800620
Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma CellsQ64122969
Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systemsQ72173760
TRPM2 channel protective properties of N-acetylcysteine on cytosolic glutathione depletion dependent oxidative stress and Ca2+ influx in rat dorsal root ganglionQ83387793
Resveratrol Treatment in Different Time-Attenuated Neuronal Apoptosis After Oxygen and Glucose Deprivation/Reoxygenation via Enhancing the Activation of Nrf-2 Signaling Pathway In VitroQ90216436
TRPM2 channel: A novel target for alleviating ischaemia-reperfusion, chronic cerebral hypo-perfusion and neonatal hypoxic-ischaemic brain damageQ90376441
Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin scaffoldQ90504909
Free radicals and neonatal encephalopathy: mechanisms of injury, biomarkers, and antioxidant treatment perspectivesQ90957320
The redox biology of redox-inert zinc ionsQ90964275
Resveratrol provides neuroprotective effects through modulation of mitochondrial dynamics and ERK1/2 regulated autophagyQ91263277
Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stressQ91526072
Emerging Roles of Sestrins in Neurodegenerative Diseases: Counteracting Oxidative Stress and BeyondQ92028632
Resveratrol attenuates cerebral ischaemia reperfusion injury via modulating mitochondrial dynamics homeostasis and activating AMPK-Mfn1 pathwayQ92195531
Mechanistic perspective of protective effects of resveratrol against cisplatin-induced ovarian injury in rats: emphasis on anti-inflammatory and anti-apoptotic effectsQ92298623
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathwayQ92617664
Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcuminQ92914225
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)6449
P577publication date2020-04-15
P1433published inScientific ReportsQ2261792
P1476titleResveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel
P478volume10

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