Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials

scientific article published on 11 December 2019

Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1470-2045(19)30691-6
P932PMC publication ID7461630
P698PubMed publication ID31838007

P50authorHerbert LoongQ60487169
P2093author name stringElizabeth Fox
Thomas John
Benjamin Besse
Luis Paz-Ares
Sant P Chawla
Ignacio Garrido-Laguna
George D Demetri
Marwan Fakih
Young Kwang Chae
Pilar Garrido
Na Cui
John C Krauss
Anna F Farago
Alexander Drilon
Timothy R Wilson
Jorge Nieva
Alice T Shaw
Robert C Doebele
Ann Johnson
Byung Chul Cho
Daniel W Bowles
Takashi Seto
Todd Riehl
Brian Simmons
Stephen V Liu
Salvatore Siena
Minal Barve
Collin M Blakely
Lyudmila Bazhenova
Conor Steuer
Edna Chow-Maneval
Diego Tosi
Gary L Buchschacher
Darren Sigal
Paul Conkling
Susan Eng
Tobias R Overbeck
trial investigators
P2860cites workThe crystal structures of TrkA and TrkB suggest key regions for achieving selective inhibitionQ27681998
Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitorQ27704291
Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.Q27852601
NTRK gene fusions as novel targets of cancer therapy across multiple tumour typesQ28066821
TRKing down an old oncogene in a new era of targeted therapyQ28254287
An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101Q28265615
Oncogenes in solid human tumoursQ28279392
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequencesQ28282360
Late recurrence in pediatric cancer: a report from the Childhood Cancer Survivor StudyQ33567577
Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal CancerQ34501536
Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung CancerQ34501607
Targeting TRK family proteins in cancerQ34550777
Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101.Q37357286
Entrectinib: a potent new TRK, ROS1, and ALK inhibitorQ38604854
Systemic Treatments in Soft Tissue SarcomasQ38759426
Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.Q38821392
Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).Q41636361
Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.Q52692152
TRKA expression and NTRK1 gene copy number across solid tumours.Q54978172
Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade gliomaQ62820070
Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 studyQ88239560
Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of NTRK, ROS1, and ALK fusion-positive solid tumorsQ90528991
Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor That Potently Inhibits ROS1/TRK/ALK Solvent- Front MutationsQ90858855
Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted TherapeuticsQ91020864
Molecular characterization of cancers with NTRK gene fusionsQ91254448
P433issue2
P921main subjectphase I clinical trialQ5452194
P304page(s)271-282
P577publication date2019-12-11
P1433published inLancet Oncology CommissionQ13747613
P1476titleEntrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials
P478volume21

Reverse relations

cites work (P2860)
Q91793281An annual review of the remarkable advances in lung cancer clinical research in 2019
Q98829676Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions
Q96128110Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
Q95840207Clinicopathologic and molecular characterization of NTRK-rearranged thyroid carcinoma (NRTC)
Q100731915Cytomorphologic features of NTRK-rearranged thyroid carcinoma
Q96341728Developing drugs for tissue agnostic indications: a paradigm shift in leveraging cancer biology for precision medicine
Q103836731Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance
Q100533696Gap between pediatric and adult approvals of molecular targeted drugs
Q96302702Histology-agnostic drug development - considering issues beyond the tissue
Q92891966Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion
Q100525979Multicentre, retrospective study of the efficacy and safety of nivolumab for recurrent and metastatic salivary gland carcinoma
Q89916769NTRK gene fusions: a rough diamond ready to sparkle
Q90308323New and Emerging Systemic Therapeutic Options for Advanced Cholangiocarcinoma
Q94465302Next-Generation Sequencing Approaches for the Identification of Pathognomonic Fusion Transcripts in Sarcomas: The Experience of the Italian ACC Sarcoma Working Group
Q100465187Problematic breast tumors reassessed in light of novel molecular data
Q95289258Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment
Q104289124Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer

Search more.