Glutamate decarboxylase 67 contributes to compensatory insulin secretion in aged pancreatic islets

scientific article published on 14 May 2019

Glutamate decarboxylase 67 contributes to compensatory insulin secretion in aged pancreatic islets is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/19382014.2019.1599708
P932PMC publication ID6548491
P698PubMed publication ID31084527

P2093author name stringYun-Il Lee
Hong Gil Nam
Won Bae Jeon
Kyeong-Min Lee
Jung Hoon Cho
P2860cites workGlucose Intolerance and Aging: Evidence for Tissue Insensitivity to InsulinQ45186876
Effects of Arg-Gly-Asp-modified elastin-like polypeptide on pseudoislet formation via up-regulation of cell adhesion molecules and extracellular matrix proteins.Q45906455
Glutamic acid decarboxylase (GAD 67) gene expression in the pancreas and brain of the nonobese diabetic mouseQ48960814
Ontogeny of glutamic acid decarboxylase gene expression in the mouse pancreas.Q52195194
GABA promotes human β-cell proliferation and modulates glucose homeostasis.Q53036011
3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondriaQ70111640
A convulsant, 3-mercaptopropionic acid, decreases the level of GABA and GAD in rat pancreatic islets and brainQ72114024
A protocol for islet isolation from mouse pancreasQ84817750
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growthQ28508976
Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin releaseQ28566284
Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinasesQ33661627
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylaseQ33744544
gamma-Aminobutyric acid outside the mammalian brainQ34372326
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylaseQ34566310
Young capillary vessels rejuvenate aged pancreatic isletsQ34709249
Aging and insulin secretionQ35027205
Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J miceQ35088094
GABA exerts protective and regenerative effects on islet beta cells and reverses diabetesQ35105197
Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neuronsQ35554433
Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistanceQ35829169
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylaseQ36190982
Pancreatic beta cells in very old mice retain capacity for compensatory proliferationQ36201786
β-cell mass and turnover in humans: effects of obesity and agingQ36477911
Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domainQ36533216
An autocrine γ-aminobutyric acid signaling system exists in pancreatic β-cell progenitors of fetal and postnatal miceQ36893699
Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cellQ38312839
PDX-1 mediates glucose responsiveness of GAD(67), but not GAD(65), gene transcription in islets of LangerhansQ38363895
Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genesQ38521913
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.Q38788371
Characterization of the rat GAD67 gene promoter reveals elements important for basal transcription and glucose responsivenessQ40770246
GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.Q41080795
Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell FunctionQ41099522
Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretionQ41114785
Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.Q41511636
Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.Q41756783
Conversion into GABA (gamma-aminobutyric acid) may reduce the capacity of L-glutamine as an insulin secretagogueQ42120897
GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.Q42507827
Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and solubleQ44979525
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue2
P304page(s)33-43
P577publication date2019-05-14
P1433published inIsletsQ26853851
P1476titleGlutamate decarboxylase 67 contributes to compensatory insulin secretion in aged pancreatic islets
P478volume11